Corelation between glucose level, lipid profile and risk of coronary heart disease associated with organophosphorus pesticide poisoning

  • Authors

    • Bhagwat Kale Lecturer, PDU Dental College Solapur
    2014-07-15
    https://doi.org/10.14419/ijbr.v2i2.2988
  • The aim of our research was to correlate blood glucose and serum lipid profile parameters with risk of coronary heart disease associated with organophosphorus pesticide poisoning. For the purpose of this, 50 patients of organophosphorus poisoning and 50 healthy controls were selected. Blood glucose and serum lipid profiles were estimated by using commercially available diagnostic kits. We found a  significant decrease (p < 0.05) in serum TAG, serum HDL cholesterol and serum VLDL cholesterol. On other hand we found a significant increase (p < 0.05) in blood glucose, serum total cholesterol and serum VLDL cholesterol. Organophosphorus poisoning is also associated with increased free radical production. Free radicals oxidize LDL cholesterol and oxidized cholesterol is taken by       macrophages to form foam cells. Foam cells are responsible for formation of atherosclerotic plaques. Such plaques reduce coronary  artery lumen and thus blood supply to heart get reduced which enhances the chances of myocardial infarction. Here, decreased HDL and VLDL and increased LDL cholesterol in organophosphorus poisoning is associated with increased risk of coronary heart diseases. Hence, estimation of blood glucose and lipid profile play important role in the diagnosis of risk of coronary heart diseases in organophosphorus poisoning.

    Keywords: Organophosphorus, Acetyl cholinesterase, Lipid Profile, Acetylcholine, Glucose.

  • References

    1. Ellenhorn M, Schonwald S, Ordog G, Wasserberger J. Ellen-horn's Medical Toxicology: Diagnosis and Treatment of Human Poisoning, Williams & Wilkins 4th edition, (1997):1614-63.
    2. Fujikawa Y, Satoh T, Suganuma S et al. Extremely sensitive biomarker of acute organophosphorus insecticide exposure. Hum Exp Toxicol; 24 (2005): 333–336. http://dx.doi.org/10.1191/0960327105ht532oa.
    3. Haque Q, Jamal F, Rastogi S (2012). Effect of organophosphorus on biochemical parameters on agriculture workers on mango orchards. Asian J Biochemistry, 7 (1): 37-45. http://dx.doi.org/10.3923/ajb.2012.37.45.
    4. Inayat-Hussain SH, Lubis SH, Sakian NI et al. Is plasma beta-glucuronidase a novel human biomarker for monitoring anticholinesterase pesticides exposure? A Malaysian experience. Toxicol Appl Pharmacol; 219 (2007): 210–216. http://dx.doi.org/10.1016/j.taap.2006.10.014.
    5. James L (2003). How to prevent and treat pesticide poison-ing.NSW agriculture; 1-3.
    6. James L. How to prevent and treat pesticide poisoning. NSW agriculture, (2003):1-3.
    7. Lee P, Tai DYH. Clinical features of patients with acute organophosphate poisoning requiring intensive care. Intensive Care Med; 27 (2001):69. http://dx.doi.org/10.1007/s001340100895.
    8. Mason H J. The recovery of plasma cholinesterase and erythro-cyte acetylcholinesterase activity in workers after overexposure to dichlorvos. Occup. Med (Lond.); 50 (2000): 343-347. http://dx.doi.org/10.1093/occmed/50.5.343.
    9. Patil J, Patil a et al. Biochemical effects of various pesticides on sprayers of grape gardens. Ind J Clin Biochem; 18/2 (2003):16–22. http://dx.doi.org/10.1007/BF02867362
    10. Roshini C, Visalakshi. Biochemical and clinical profile after organophosphorus are poisoning-A plasebo-controlled trial using pralidoxime. J Assoc Physicians India; 53 (2005):422–4.
    11. Satoh T, Suzuki S, Kawai N, Nakamura T, Hosokawa M. Toxicological significance in the cleavage of esterase–beta-glucuronidase complex in liver microsomes by organophosphorus compounds. Chem Biol Interact; 119 (1999): 471–478. http://dx.doi.org/10.1016/S0009-2797 (99)00060-5.
    12. Ubale V et al. Text book of organic chemistry B.Sc.-part III, Paper – VII 2nd edition (2007):10.1-15.
  • Downloads

  • How to Cite

    Kale, B. (2014). Corelation between glucose level, lipid profile and risk of coronary heart disease associated with organophosphorus pesticide poisoning. International Journal of Biological Research, 2(2), 78-80. https://doi.org/10.14419/ijbr.v2i2.2988