Group A, G and C β-hemolytic Streptococci

  • Authors

    • Shobha K.L Department of MicrobiologyMelaka Manipal Medical CollegeManipal CampusManipal UniversityManipal
    • Kusumakshi N. Department of MLT,MU,Manipal
    • Vishnu Prasad Department of Microbiology,KMC,MU,Manipal
    • Ramachandra L. Department of Surgery Kasturba Medical College Manipal University Manipal
    2015-01-05
    https://doi.org/10.14419/ijm.v3i1.3910
  • Group A C And G Streptococcus, Pharyngitis, M Protein, Emm Genes.

  • Group A Streptococcus (GAS) is the most common causative agent of sore throat, pharyngitis, skin infections, rheumatic fever (RF), rheumatoid heart disease (RHD) and glomerulonephritis in young adults. Group G and C streptococcal species are also known to cause complications like acute rheumatic fever and rheumatic heart disease. Isolation of these from the throat could be a warning signal so that the further complications can be prevented. Estimation of prevalence could help clinicians to make informed decisions regarding diagnostic testing of children with symptoms of sore throat and pharyngitis. M protein both GAS and GGS/GCS share in many virulence factors that contribute to virulence, some of which act as collagen binding adhesins that facilitate acute infection. Both GAS and GGS/GCS can cause similar spectrum of disease symptoms. The sequenced M Protein provides a view into the genetic elements responsible for diversity in the species. emm types historically associated with RF are rarely seen in India. The epidemiologic picture of streptococci in India shows some of the serotypes are more common with in a population in different geographical area.

  • References

    1. [1] Asrat D, Kronvall G, Shitu B, Achiko D, Zeidan M, et al. Throat carriage rate and antimicrobial susceptibility pattern of group A Streptococci (GAS) in healthy Ethiopian school children. Ethio Med. 2011; 49 (2):125–30.

      [2] Chopra P, Gulwani H. Pathology and Pathogenesis of Rheumatic Heart Disease. Indian J Pathol Microbiol. 2007; 50(4):685–97.

      [3] Nandi S, Kumar R, Ray P, Vohra H, Ganguly NK. Group a streptococcal sore throat in a periurban population of northern India: a one-year prospective study. Bull World Health Organ [Internet]. 2001 Jan; 79(6):528–33. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2566441&tool=pmcentrez&rendertype=abstract.

      [4] Shimomura Y, Okumura K, Murayama SY, Yagi J, Ubukata K, Kirikae T, et al. Complete genome sequencing and analysis of a Lancefield group G Streptococcus dysgalactiae subsp. equisimilis strain causing streptococcal toxic shock syndrome (STSS). BMC Genomics [Internet]. BioMed Central Ltd; 2011 Jan [cited 2014 Apr 8]; 12(1):17. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3027156&tool=pmcentrez&rendertype=abstract

      [5] Takahashi T, Ubukata K, Watanabe H. Invasive infection caused by Streptococcus dysgalactiae subsp. equisimilis: characteristics of strains and clinical features. Infect Chemother. 2011; 17(1):1–10. http://dx.doi.org/10.1007/s10156-010-0084-2.

      [6] Ruoff KL. Streptococcus anginosus (" Streptococcus milleri "): The Unrecognized Pathogen. Clin Microbiol Rev. 1988; 1(1):102–8.

      [7] McMillan DJ, Vu T, Bramhachari P V, Kaul SY, Bouvet a, Shaila MS, et al. Molecular markers for discriminating Streptococcus pyogenes and S. dysgalactiae subspecies equisimilis. Eur J Clin Microbiol Infect Dis [Internet]. 2010 May [cited 2014 Mar 24]; 29(5):585–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20221892.

      [8] Bramhachari P V, Kaul SY, McMillan DJ, Shaila MS, Karmarkar MG, Sriprakash KS. Disease burden due to Streptococcus dysgalactiae subsp. equisimilis (group G and C streptococcus) is higher than that due to Streptococcus pyogenes among Mumbai school children. J Med Microbiol [Internet]. 2010 Feb [cited 2014 Apr 8]; 59(Pt 2):220–3. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19833781.

      [9] Mcdonald M, Towers R, Fagan P, Mckinnon M, Benger N, Andrews R, et al. Recovering Streptococci from the Throat, a Practical Alternative to Direct Plating in Remote Tropical Communities. 2006; 44(2):547–52.

      [10] Cunningham MW. Pathogenesis of group A streptococcal infections. Clin Microbiol Rev [Internet]. 2000 Jul; 13(3):470–511. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18193655. http://dx.doi.org/10.1128/CMR.13.3.470-511.2000.

      [11] Guilherme L, Kalil J, Cunningham M. Molecular mimicry in the autoimmune pathogenesis of rheumatic heart disease. Autoimmunity [Internet]. 2006 Mar [cited 2014 May 30]; 39(1):31–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16455580.

      [12] Smoot JC, Barbian KD, Van Gompel JJ, Smoot LM, Chaussee MS, Sylva GL, et al. Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks. Proc Natl Acad Sci U S A [Internet]. 2002 Apr 2; 99(7):4668–73. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=123705&tool=pmcentrez&rendertype=abstract. http://dx.doi.org/10.1073/pnas.062526099.

      [13] Dey N, McMillan DJ, Yarwood PJ, Joshi RM, Kumar R, Good MF, et al. High diversity of group A Streptococcal emm types in an Indian community: the need to tailor multivalent vaccines. Clin Infect Dis [Internet]. 2005 Jan 1; 40(1):46–51. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15614691. http://dx.doi.org/10.1086/426443.

      [14] Kumar R, Vohra H, Chakraborty A, Sharma YP, Bandhopadhya S, Dhanda V, et al. Epidemiology of group a streptococcal pharyngitis & impetigo : A cross-sectional & follow up study in a rural community of northern India. 2009 ;( December):765–71.

      [15] Reissmann S, Friedrichs C, Rajkumari R, Itzek A, Fulde M, Rodloff AC, et al. Contribution of Streptococcus anginosus to infections caused by groups C and G streptococci, southern India. Emerg Infect Dis [Internet]. 2010 Apr [cited 2014 Apr 8]; 16(4):656–63. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3321935&tool=pmcentrez&rendertype=abstract.

      [16] Mark R, David J, Donald L, Bart J, Kadaba S. Inter-species genetic movement may blur the epidemiology of streptococcal diseases in endemic regions. J Infect agents host defenses. 2005; 7(9-10):1128–38.

      [17] Brandt CM, Spellerberg B. Human infections due to Streptococcus dysgalactiae subspecies equisimilis. Clin Infect Dis [Internet]. 2009 Sep 1 [cited 2014 Mar 24]; 49(5):766–72. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19635028.

      [18] 18. HaidanA, Talay SR, Rohde M, Sriprakash KS, Currie BJ, Chhatwal GS. Pharyngeal carriage of group C and group G streptococci and acute rheumatic fever in an Aboriginal population. Lancet [Internet]. 2000 Sep 30 [cited 2014 May 30]; 356(9236):1167–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11030302

      [19] Williams GS. Group C and G Streptococciinfections: Emerging Challenges. 2003. p. 209–13.

      [20] Reid H, Bassett D, -King TP, Zabriskie J, Read S. Group G Streptococci in healthy school-children and in patients with glomerulonephritis in Trinidad. J Hyg. 1985; 94(January 1967):61–8.

      [21] Stollerman G. Rheumatic fever. 1997. p. 349:935–942.

      [22] Tb M, Jl H, Nh A, Ar P, Va F, Jb Z, et al. Comprehensive analysis of antibody responses to streptococcal and tissue antigens in patients with acute rheumatic fever . 2008; 20(3):2008.

      [23] Efstratiou A. Pyogenic streptococci of Lancefield groups C and G as pathogens in man. Soc Appl Bacteriol Symp Ser [Internet]. 1997 Jan; 26:72S–79S. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9436319. http://dx.doi.org/10.1046/j.1365-2672.83.s1.8.x.

      [24] Sriprakash KS& HJ. Lateral genetic transfer between Group A and G Streptococci for M like genes are ongoing. MicrobPathog. 1996; 20, 275-285. MicrobPathog. 1996; 20:275–85. http://dx.doi.org/10.1006/mpat.1996.0026.

      [25] Towers RJ, Gal D, Mcmillan D, Sriprakash KS, Currie BJ, Walker MJ, et al. Fibronectin-Binding Protein Gene Recombination and Horizontal Transfer between Group A and G Streptococci. Clin Microbiol. 2004; 42(11):5357–61. http://dx.doi.org/10.1128/JCM.42.11.5357-5361.2004.

      [26] Mg R, Nerlich A, Bergmann R, Bexiga R, Sf N, Cl V, et al. Virulence gene pool detected in bovine group C Streptococcus dysgalactiae subsp . dysgalactiae isolates by use of a group A S . pyogenes virulence microarray . J Clin Microbiol. 2011; 49(7):2470. http://dx.doi.org/10.1128/JCM.00008-11.

      [27] Brahmadathan KN KG. Importance of Group G Streptococci in human pyogenic infections. 1989:92:35-8. J trop med Hyg. 1989; 92:35–8.

      [28] Menon T, Shanmugasundaram S, Kumar MP, Kumar CPG. Group a streptococcal infection of the pharynx in a rural population in south India. 2004; 119(May):171–3.

      [29] Navaneeth B V, Ray N, Chawda S, Selvarani P, Bhaskar M, Suganthi N. Prevalence of beta hemolytic streptococci carrier rate among schoolchildren in Salem. Indian J Pediatr [Internet]. 2001 Oct; 68(10):985–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11758139. http://dx.doi.org/10.1007/BF02722602.

      [30] Anand T, Rajesh T, Rajendhran J, Gunasekaran P. Superantigen profiles of emm and emm-like typeable and nontypeable pharyngeal streptococcal isolates of South India. Ann Clin Microbiol Antimicrob [Internet]. BioMed Central Ltd; 2012 Jan [cited 2014 Apr 8]; 11(1):3. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3296615&tool=pmcentrez&rendertype=abstract.

      [31] Lioyd C, Jacob S, Menon T. Pharyngeal Carriage of group A STreptococci in school children in chennai. Indian J Med Res. 2006; 124(2):195–8.

      [32] Kalpana S, Sundar JS, Parameshwari S, Kuganantham P, Selvam JM, Valarmathi MS, et al. Isolation and Identification of Group A Streptococcal Infection Among Slum Children in the Age Group of 5-15 Years in Chennai - One Year Prospective Study. 2012; 2(1):27–30.

      [33] Pavanchand, N Aravind KV. Throat Carriage and Antibiogram Pattern of Group A & Group G Beta Hemolytic Streptococci among School Children in Mangalore. Int J Adv Res. 2014; 2(6):1074–8.

      [34] Vijaya D, Sathish J V JK. The Prevalence of Group A Streptococci Carriers among Asymptomatic School Children. J Clin Diagnostic Res. 2013; 7(3):446–8.

      [35] Lakshmana Gowda K, John Melbin J, Patil S a., Bindu Rani SR, Sanjay MK, Shivannavar CT, et al. Prevalence of emm types of Group A streptococci recovered from school children and hospital patients in Bangalore City, India. World J Microbiol Biotechnol [Internet]. 2010 Jun 5 [cited 2014 May 30]; 27(2):319–23. Available from: http://link.springer.com/10.1007/s11274-010-0461-0

      [36] Kushwaha N, Kamat M, Banjade B, Sah J. Prevalence of Group-A Streptococcal Infection Among School Children of Urban Community – A Cross Sectional Study Sample Size : Sampling Technique : Inclusion Criteria : Exclusion Criteria: 2014;1(5):249–56.

      [37] Mathur P, Kapil A, Das B. Prevalence of group G & group C streptococci at an Indian tertiary care centre. Indian J Med Res [Internet]. 2004 Sep; 120(3):199–200. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15489558.

      [38] Kumar R, Chakraborti a, Aggarwal a K, Vohra H, Sagar V, Dhanda V, et al. Streptococcus pyogenes pharyngitis & impetigo in a rural area of Panchkula district in Haryana, India. Indian J Med Res [Internet]. 2012 Jan; 135:133–6. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3307175&tool=pmcentrez&rendertype=abstract

      [39] Nandi S, Kumar R, Ray P, Vohra H, Ganguly NK. Group a streptococcal sore throat in a periurban population of northern India: a one-year prospective study. Bull World Health Organ [Internet]. 2001 Jan; 79(6):528–33. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2566441&tool=pmcentrez&rendertype=abstract

      [40] 40. Prakash K, Laksmy A. Streptococcal throat carriage in school children with special reference to seasonal incidence. Southyeast Asian J Trop Med Public Heal. 1992; 23(4):705–10.

      [41] Olender A, Åetowska I, KaryÅ„ski M, Kiernicka-Ciekot K, Pels K. [Problems with identification of beta-hemolytic streptococcus resistant to bacitracin isolated from patients with pharyngitis]. Med Dosw Mikrobiol [Internet]. 2012 Jan; 64(1):1–10. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22808724.

      [42] Washington JA. Principles of Diagnosis. Medical Microbiology, 4th Edition, 1996.

      [43] Baron EJ. Rapid identification of bacteria and yeast: summary of a National Committee for Clinical Laboratory Standards proposed guideline. Clin Infect Dis. 2001; 33(2):220–5. http://dx.doi.org/10.1086/321816.

      [44] Hussain Z, Lannigan R, Stoakes L. A new approach for presumptive identification of clinically important streptococci. Zentralbl Bakteriol Mikrobiol Hyg A [Internet]. 1984 Oct; 258(1):74–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/6441390.

      [45] Gunn BA, Ohashi DK, Gaydos CA, Holt ES. Selective and Enhanced Recovery of Group A and B Streptococci from Throat Cultures with Sheep Blood Agar Containing Sulfamethoxazole and Trimethoprim. 1977; 5(6):650–5.

      [46] Hayden GF, Turner JC, Kiselica D, Dunn M, Hendley JO, Carolina S. Latex Agglutination Testing Directly from Throat Swabs for Rapid Detection of Beta-Hemolytic Streptococci from Lancefield Serogroup C. 1992;30(3):716–8.

      [47] Slifkin M, Engwall C, Pouchet GR. Direct-plate serological grouping of beta-hemolytic streptococci from primary isolation plates with the Phadebact streptococcus test. J Clin Microbiol [Internet]. 1978 Apr; 7(4):356–60. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=274967&tool=pmcentrez&rendertype=abstract.

      [48] Vereanu a, Mihalcu F. Improved lysotyping scheme for group C streptococci with new phage preparations. Arch Roum Pathol expérimentales Microbiol [Internet]. 1979; 38(3-4):265–72. Available from: http://www.ncbi.nlm.nih.gov/pubmed/401357.

      [49] Lancefield BRC. A SEROLOGICAL D I F F E R E N T I A T I O N OF HUMAN AND (From the Hospital of the Rockefeller Institute for Medical Research). 1932; 1919(1):571–95.

      [50] Facklam R. What Happened to the Streptococci : Overview of Taxonomic and Nomenclature Changes What Happened to the Streptococci: Overview of Taxonomic and Nomenclature Changes. 2002; 15(4).

      [51] Kirby R, Ruoff KL. Cost-effective, clinically relevant method for rapid identification of beta-hemolytic streptococci and enterococci. J Clin Microbiol [Internet]. 1995 May; 33(5):1154–7. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=228122&tool=pmcentrez&rendertype=abstract.

      [52] Brandt CM, Haase G, Schnitzler N, Zbinden R. Characterization of Blood Culture Isolates of Streptococcus dysgalactiae subsp . equisimilis Possessing Lancefield ' s Group A Antigen. 1999; 37(12):4194–7.

      [53] Ambu M, Thangam M. Bio typing of Group Streptococci isolated from Normal School children in South India. Indian J Pract Dr. 2005; 2(1).

      [54] Burden D. Acute Rheumatic Fever : Current Scenario in India. 2010; 199–212.

      [55] Brandt ER, Teh T, Relf W a, Hobb RI, Good MF. Protective and nonprotective epitopes from amino termini of M proteins from Australian aboriginal isolates and reference strains of group streptococci. Infect Immun [Internet]. 2000 Dec; 68(12):6587–94. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=97754&tool=pmcentrez&rendertype=abstract. http://dx.doi.org/10.1128/IAI.68.12.6587-6594.2000.

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    K.L, S., N., K., Prasad, V., & L., R. (2015). Group A, G and C β-hemolytic Streptococci. International Journal of Medicine, 3(1), 8-11. https://doi.org/10.14419/ijm.v3i1.3910