Serum vitamin D and anti- mullerian hormone levels in Iraqi infertile women at Baghdad city

  • Authors

    • Omar Rasheed Department of Chemistry and Biochemistry, College of Medicine, Al- Nahrain University
    • Noor Ali Department of Chemistry and Biochemistry, College of Medicine, Al- Nahrain University
    • Enaas Abdulrasul Department of Obstetrics and Gynecology, College of Medicine, Al- Nahrain University
    2015-10-30
    https://doi.org/10.14419/ijbas.v4i4.5140
  • Vitamin D, Female Infertility, Anti- Mullerian Hormone, Mullerian Inhibiting Substance, Ovarian Reserve.

  • Abstract

    Background: Reproductive failure is a significant public health concern. Although relatively little is known about factors affecting fertility, a growing body of literature suggests that environmental & lifestyle factors play an important role. Recent studies suggest that vitamin D may play a role in human reproduction. Exact mechanisms whereby vitamin D may participate in the regulation of reproductive physiology remains far from clear.

    Objective: To validate the potential of vitamin D as a biomarker for prediction of female infertility and to study the correlation between vitamin D and Anti- Mullerian hormone.

    Methods: A case- control study was conducted at Department of Chemistry and Biochemistry, College of Medicine, Al- Nahrain University, Al- Kadhmiya, Baghdad, Iraq from June 2013 till July 2014. Seventy three subjects were enrolled in this study. Thirty five primary infertile women with mean age (25.4± 4.91 years), and thirty eight age- matched apparently healthy women as controls with mean age (27.3±3.72 years). Fasting blood samples were collected in the morning at 8:00 am from all participants. Vitamin D was measured by high-performance liquid chromatography technique and Anti- Mullerian hormone was measured by enzyme- linked immunosorbent assay.

    Results: Vitamin D levels was significantly decreased in the infertile women group compared with fertile control group (35.38±5.83 ng/ mL) versus (49.99±12.90 ng/ mL) respectively. Vitamin D correlated significantly (r = +0.86; p ≤ 0.05) with anti-mullerian hormone and anti- mullerian hormone shows a significant negative correlation with body mass index (r = -0.78; p ≤ 0.05).

    Conclusion: A novel relationship was found between circulating Anti- Mullerian hormone and vitamin D in plasma samples of infertile women.

    Author Biography

    • Omar Rasheed, Department of Chemistry and Biochemistry, College of Medicine, Al- Nahrain University

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    Rasheed, O., Ali, N., & Abdulrasul, E. (2015). Serum vitamin D and anti- mullerian hormone levels in Iraqi infertile women at Baghdad city. International Journal of Basic and Applied Sciences, 4(4), 375-380. https://doi.org/10.14419/ijbas.v4i4.5140

    Received date: 2015-08-02

    Accepted date: 2015-10-25

    Published date: 2015-10-30