Interesting Mechanistic Approach for Nitrogen Heterocycles of Industrial Importance

  • Authors

    • N.D. Zargar Higher Education University of Kashmir ,Srinagar,India
    • K.Z. Khan
    2018-04-23
    https://doi.org/10.14419/ijac.v6i1.10382
  • N-Heterocycles, Porphyrins, Selfassembly, Fungicidal, Pyrrole Rings, Phthalimide, Dye, Polymer, Indole, Triazolines.

  • Abstract

    Nitrogen heterocycles have played an important role in different industrial sectors.Porphyrins the macrocyclic compounds containing pyrrole rings provide an extremely versatile platform with desired peripheral functionality and metal complexes to form the self assembly under varying reaction conditions. Haemoglobin an iron complex is responsible for binding molecular oxygen and transporting it to different sites. Mechanistically interesting N-heterocycles, Arylidene-1,3-indandione adducts (6) and (7) synthesized frequently are of immense pharmaceutical importance showing fungicidal and bactericidal activities. Nitrogen heteroatom phthalimide derivatives(8),(9) and (10) have been evaluated as possible potential prodrugs. A wide range of Nitrogen heterocycles have been synthesized for every imaginable use in dye and polymer industries.

  • References

    1. [1] Thiophens and Benzothiophens,Aromatic and Heteroaromatic Chemistry Vol.7,Pocar.D,Rossi.L.M, Stradi .R and Trimarco.P,(1977);J.C.S. Perkin -1,2337.

      [2] Thiophens and Benzothiophens,Aromatic and Heteroaromatic Chemistry Vol.7,Oe.K,Tashiro.M and Tsuge.O,(1977);Bull.Chem.Soc.Japan,50,3281).https://doi.org/10.1246/bcsj.50.3281.

      [3] Indoles, Aromatic and Heteroaromatic Chemistry, Decodts.G; (1976). Bull.Soc.Chim.France, 1839.

      [4] Abika.M, Kosugi.Y and Takada.T, (1977); Heterocycles, 6, 1125. View at Google scholar/View at publisher.

      [5] Aromatic and Heteroaromatic Chemistry,Takada.T, Kosugi.Y and Akiba.M (1977); Chem. and Pharm. Bull. (Japan), 25,543.

      [6] Heterocyclic Compounds, Organic Chemistry;Finar.I.L,(1986) , The Fundamental Principles(6thedition),Vol.1,826-864.

      [7] Indazoles,Five membered Ring Systems, Suschitzky.H and Meth-Cohn.O (1979) ;Aromatic and Heteroaromatic Chemistry,Vol.7,55.

      [8] Self-Assembly of Selected 5, 10, 15, 20-Tetraarylporphyrins,Anderson.H.L (1999);Chem.Comm. 2323-2330

      [9] Self-Assembly of Selected 5,10,15,20-Tetraarylporphyrins,Loewe.J.S, Tomizaki.K, Youngblood.W.J, BO.A and Linsay.J.S (2002) ;J.Mater.Chem.12,3434-3451.

      [10] [10]. Large Third-Order Optical Nonlinearity of Self-Assembled Porphyrin Oligomers Ogawa.K,Zang.T, Yoshihara.K and Kobuke.Y(2002) ; J.Am.Chem.Soc. 124,22-23.

      [11] Functional SupramolecularChemistry,Seidel.S.R and Stang.P.J (2002); Acc.Chem.Res.35,972-983. https://doi.org/10.1021/ar010142d.

      [12] Stang.P.J. and Lenyuk.B.O (1997); Acc.Chem.Res.30,502-578. View at Google scholar/View at publisher.

      [13] Concepts and Perspectives, Lehn.J.M (1995); Supramolecular Chemistry; VHC- Publishers, Weinhim.

      [14] Noncovalent Synthesis: Using Physical-Organic Chemistry To Make Aggregates Whiteside.G.M,Simanek.E.E et.al (1995) ; Acc.Chem.Res.28,1,37-44. https://doi.org/10.1021/ar00049a006.

      [15] Self-Assembling Supramolecular Complexes. Lawrence.D.S,Jiang.T and Levett.M (1995); Chem.Rev.95,6,2229-2260.https://doi.org/10.1021/cr00038a018.

      [16] The Fiveâ€Stage Selfâ€Assembly of a Branched Heptacatenane,Philip.D and Soddart.J.F (1996);Angew Chem.Int.Ed.Engl.35, 1154-1196. https://doi.org/10.1002/anie.199611541.

      [17] Alessio.E, Lengo.E and Marzilli.L.G (2002);Supramolecular Chem.14, 103-120.View at Google scholar/View at publisher.

      [18] Formation of Artificial Receptors by Metal-Templated Self-Assembly Linton.B and Hamilton.A.D(1997);Chem.Rev. 97, 5, 1669-1680. https://doi.org/10.1021/cr960375w.

      [19] Burrel.A.K, Wasielewski.M.R (2000);J.Porph.Phthal. 4,401.View at Google scholar/View at publisher.

      [20] Susklie.K.S,Rakow.N.A ,et.al (2000) ; J.Porph.Phthal. 4,407. View at Google scholar/View at publisher.

      [21] Osman.S.A.M, Yousif.N.M,Ahmad.F.H and Hamman.A.G(1988) (Pub.1990) ; Egypt.J.Chem. 31,6,727-34 (Eng.).View at Google scholar/View at publisher.

      [22] EI.F.Z, Ablak and Matwally.M.A (1992); J.Serb.Chem. Soc. 57,10,635-40 (Eng.).View at Google scholar/View at publisher.

      [23] Khan.M.N (1990); Chem. Abst. 112,97960e.View at Google scholar/View at publisher.

      [24] Omar.A.F (1998);Eur.J.Med.Chem. 33, 2,123-131 (Eng.).View at Google scholar/View at publisher.https://doi.org/10.1016/S0223-5234(98)80037-8.

      [25] Ebihara.K, Oora.T,et.al. Jpn.Kokai, Tokkyo, Koho.JP.08, 245, 585,[96,245,585].(Cl.CO7D 209/48). View at Google scholar/View at publisher.

      [26] Recent Advances and Future Prospects of Phthalimide Derivatives,Kushwanta.N, Kaushik.D,(2016); J.Appl. Pharm.Sci. 6,159-171.

      [27] Isoindole Derivatives: Propitious Anticancer Structural Motifs, Bhatia.R.K (2017); Curr. Top. Med. Chem. 17, 189-207. https://doi.org/10.2174/1568026616666160530154100.

      [28] Approaches to the Formation of Condensed Isoindolones,Csende.F and Stajer.S (2005) ; Curr.Org.Chem. 9, 1261-1276. https://doi.org/10.2174/1385272054863961.

      [29] Frlan.R, Gobec.S (2017); Expert Opin.Ther.Pat.27, 637-641.View at Google scholar/View at publisher.

      [30] Recent developments in the synthesis of heterocycle-fused isoindoles, Csende.F,Miklos .F ;et.al (2012) ; Curr.Org.Chem. 16, 1005-1050. https://doi.org/10.2174/138527212800194683.

      [31] An Overview for the Chemistry of Pyridazinones , Soliman.A.A, Kandil.N.G,Sawi-EI(1989) ; J.Org.Chem. 19,8,779.

      [32] Chemistry of the Anionically Activated Perfluoroalkyl Group in Heterocyclic Synthesis Strekowski.L, Mokroxz.R.L et.al (1991); J.Med. Chem. 34, 1739. https://doi.org/10.1021/jm00109a031.

      [33] (a) Chemistry of the Anionically Activated Perfluoroalkyl Group in Heterocyclic Synthesis,,Zhao.M, Janda.L,et.al (1994) ; Biopolymers, 34,61. (b) Strekowski.L, Wilson. W. D et.al (1993); Current Topics in Med.Chem.1, 33. View at Google scholar/View at publisher. (c) Wilson.W.D, Zhao.M, et.al (1992); Med. Chem. Res. 2,102.View at Google scholar/View at publisherhttps://doi.org/10.1002/bip.360340108.

      [34] Synthesis of 1, 2, 3-Triazole-Thiazolidines and their Arylidenes as Antifungal Agent, Srivastava.S.D et.al (2002);Ind.J.Chem. Katrizky.A.R and Rees.C.W (1984); Comprehensive Heterocyclic Chemistry; Pergamon press.

      [35] Pengfei.Xu,Xinping.Y, Shaozu.W and Ziyi.Z (1998) ; Ind. J.Chem. 37B, 127. (Ref.34/Google Scholar). View at Google scholar/View at publisher.

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    Zargar, N., & Khan, K. (2018). Interesting Mechanistic Approach for Nitrogen Heterocycles of Industrial Importance. International Journal of Advanced Chemistry, 6(1), 89-94. https://doi.org/10.14419/ijac.v6i1.10382

    Received date: 2018-03-20

    Accepted date: 2018-04-16

    Published date: 2018-04-23