Green synthesis and antibacterial evaluation of some 2-pyrazoline derivatives

Authors

  • N. Santhi ASSOCIATE PROFESSOR OF CHEMISTRY GOVERNMENT ARTS COLLEGE CHIDAMBARAM
  • M. Emayavaramban RESEARCH SCHOLAR
  • C. Gopi RESEARCH SCHOLAR
  • C. Manivannan RESEARCH SCHOLAR
  • A. Raguraman RESEARCH SCHOLAR

DOI:

https://doi.org/10.14419/ijac.v2i2.1851

Published:

2014-03-09

Abstract

A Chalcone (3) was prepared by the reaction of 4-methylbenzaldehyde (1) with 4-methylacetophenone (2) in methanolic sodium hydroxide result under ultrasonic irradiation in the water bath of a ultrasonic cleaner at room temperature. Treatment of this chalcone with thiosemicarbazide / semicarbazide hydrochloride / benzhydrazide / benzenesulphonyl hydrazide / phenylhydrazine hydrochloride managed the comparing 2-pyrazoline (4-8) in great yields. All the new mixes have been described by IR, 1H-NMR, 13CNMR ghostly information. All the target mixes were assessed for their in-vitro against antifungal in examination with as reference pill.

 

Keywords: 4-Methylbenzaldehyde, 4-Methyl Acetophenone, Ultrasonic Irradiation, Chalcone, 2-Pyrazoline, Antibacterial.

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