A comprehensive review on functional roles of cancerous immunoglobulins and potential applications in cancer immunodiagnostics and immunotherapy

  • Authors

    • Alireza Heidari Faculty of Chemistry, California South University (CSU), Irvine, California, USA
    • Victoria Peterson Faculty of Chemistry, California South University (CSU), Irvine, California, USA
    2020-04-18
    https://doi.org/10.14419/ijac.v8i1.30500
  • Cancerous Immunoglobulins, Cancer Immunodiagnostics, Cancer Immunotherapy.

  • Abstract

    In this research, poly (D, L-lactide-co-glycolide)-block-poly (ethylene glycol), (PLGA-PEG) nanoparticles (NPs) of less than 195 nm in diameter containing of Naringenin (NRG) a naturally flavonoid were synthesized. Encapsulated form NRG improves its medical properties and solubility. The therapeutic efficacy of the encapsulated naringenin (NRG-NPs) and NRG on human lung epithelial (A549) and mouse mammary (4T1) carcinoma cells proliferation was determined by MTT assays. The cytotoxicity potency was rated as follows: NRG-NPs > NRG. The antioxidant effects of the NRG and NRG-NPs were also determined by FRAP method. Our results show that NRG-NPs are cytotoxic compounds for cancer cells and anti-cancer effect can be attributed to the presence of Fe chelatory and antioxidant effects of NRG-NPs.

     

     

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      [101] A. Heidari, “Visualizing Metabolic Changes in Probing Human Cancer Cells and Tissues Metabolism Using Vivo 1H or Proton NMR, 13C NMR, 15N NMR and 31P NMR Spectroscopy and Self–Organizing Maps under Synchrotron Radiationâ€, SOJ Mater Sci Eng 5 (2): 1–6, 2017.

      [102] A. Heidari, “Cavity Ring–Down Spectroscopy (CRDS), Circular Dichroism Spectroscopy, Cold Vapour Atomic Fluorescence Spectroscopy and Correlation Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiationâ€, Enliven: Challenges Cancer Detect Ther 4 (2): e001, 2017.

      [103] A. Heidari, “Laser Spectroscopy, Laser–Induced Breakdown Spectroscopy and Laser–Induced Plasma Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiationâ€, Int J Hepatol Gastroenterol, 3 (4): 079–084, 2017.

      [104] A. Heidari, “Time–Resolved Spectroscopy and Time–Stretch Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiationâ€, Enliven: Pharmacovigilance and Drug Safety 4 (2): e001, 2017.

      [105] A. Heidari, “Overview of the Role of Vitamins in Reducing Negative Effect of Decapeptyl (Triptorelin Acetate or Pamoate Salts) on Prostate Cancer Cells and Tissues in Prostate Cancer Treatment Process through Transformation of Malignant Prostate Tumors into Benign Prostate Tumors under Synchrotron Radiationâ€, Open J Anal Bioanal Chem 1 (1): 021–026, 2017.

      [106] A. Heidari, “Electron Phenomenological Spectroscopy, Electron Paramagnetic Resonance (EPR) Spectroscopy and Electron Spin Resonance (ESR) Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiationâ€, Austin J Anal Pharm Chem. 4 (3): 1091, 2017.

      [107] A. Heidari, “Therapeutic Nanomedicine Different High–Resolution Experimental Images and Computational Simulations for Human Brain Cancer Cells and Tissues Using Nanocarriers Deliver DNA/RNA to Brain Tumors under Synchrotron Radiation with the Passage of Time Using Mathematica and MATLABâ€, Madridge J Nano Tech. Sci. 2 (2): 77–83, 2017.

      [108] A. Heidari, “A Consensus and Prospective Study on Restoring Cadmium Oxide (CdO) Nanoparticles Sensitivity in Recurrent Ovarian Cancer by Extending the Cadmium Oxide (CdO) Nanoparticles–Free Interval Using Synchrotron Radiation Therapy as Antibody–Drug Conjugate for the Treatment of Limited–Stage Small Cell Diverse Epithelial Cancersâ€, Cancer Clin Res Rep, 1: 2, e001, 2017.

      [109] A. Heidari, “A Novel and Modern Experimental Imaging and Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under White Synchrotron Radiationâ€, Cancer Sci Res Open Access 4 (2): 1–8, 2017.

      [110] A. Heidari, “Different High–Resolution Simulations of Medical, Medicinal, Clinical, Pharmaceutical and Therapeutics Oncology of Human Breast Cancer Translational Nano Drugs Delivery Treatment Process under Synchrotron and X–Ray Radiationsâ€, J Oral Cancer Res 1 (1): 12–17, 2017.

      [111] A. Heidari, “Vibrational Decihertz (dHz), Centihertz (cHz), Millihertz (mHz), Microhertz (μHz), Nanohertz (nHz), Picohertz (pHz), Femtohertz (fHz), Attohertz (aHz), Zeptohertz (zHz) and Yoctohertz (yHz) Imaging and Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiationâ€, International Journal of Biomedicine, 7 (4), 335–340, 2017.

      [112] A. Heidari, “Force Spectroscopy and Fluorescence Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiationâ€, EC Cancer, 2 (5), 239–246, 2017.

      [113] A. Heidari, “Photoacoustic Spectroscopy, Photoemission Spectroscopy and Photothermal Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiationâ€, BAOJ Cancer Res Ther, 3: 3, 045–052, 2017.

      [114] A. Heidari, “J–Spectroscopy, Exchange Spectroscopy (EXSY), Nucle­ar Overhauser Effect Spectroscopy (NOESY) and Total Correlation Spectroscopy (TOCSY) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiationâ€, EMS Eng Sci J, 1 (2): 006–013, 2017.

      [115] A. Heidari, “Neutron Spin Echo Spectroscopy and Spin Noise Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiationâ€, Int J Biopharm Sci, 1: 103–107, 2017.

      [116] A. Heidari, “Vibrational Decahertz (daHz), Hectohertz (hHz), Kilohertz (kHz), Megahertz (MHz), Gigahertz (GHz), Terahertz (THz), Petahertz (PHz), Exahertz (EHz), Zettahertz (ZHz) and Yottahertz (YHz) Imaging and Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiationâ€, Madridge J Anal Sci Instrum, 2 (1): 41–46, 2017.

      [117] A. Heidari, “Two–Dimensional Infrared Correlation Spectroscopy, Linear Two–Dimensional Infrared Spectroscopy and Non–Linear Two–Dimensional Infrared Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation with the Passage of Timeâ€, J Mater Sci Nanotechnol 6 (1): 101, 2018.

      [118] A. Heidari, “Fourier Transform Infrared (FTIR) Spectroscopy, Near–Infrared Spectroscopy (NIRS) and Mid–Infrared Spectroscopy (MIRS) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation with the Passage of Timeâ€, Int J Nanotechnol Nanomed, Volume 3, Issue 1, Pages 1–6, 2018.

      [119] A. Heidari, “Infrared Photo Dissociation Spectroscopy and Infrared Correlation Table Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation with the Passage of Timeâ€, Austin Pharmacol Pharm, 3 (1): 1011, 2018.

      [120] A. Heidari, “Novel and Transcendental Prevention, Diagnosis and Treatment Strategies for Investigation of Interaction among Human Blood Cancer Cells, Tissues, Tumors and Metastases with Synchrotron Radiation under Anti–Cancer Nano Drugs Delivery Efficacy Using MATLAB Modeling and Simulationâ€, Madridge J Nov Drug Res, 1 (1): 18–24, 2017.

      [121] A. Heidari, “Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiationâ€, Open Access J Trans Med Res, 2 (1): 00026–00032, 2018.

      [122] M. R. R. Gobato, R. Gobato, A. Heidari, “Planting of Jaboticaba Trees for Landscape Repair of Degraded Areaâ€, Landscape Architecture and Regional Planning, Vol. 3, No. 1, 2018, Pages 1–9, 2018.

      [123] A. Heidari, “Fluorescence Spectroscopy, Phosphorescence Spectroscopy and Luminescence Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation with the Passage of Timeâ€, SM J Clin. Med. Imaging, 4 (1): 1018, 2018.

      [124] A. Heidari, “Nuclear Inelastic Scattering Spectroscopy (NISS) and Nuclear Inelastic Absorption Spectroscopy (NIAS) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiationâ€, Int J Pharm Sci, 2 (1): 1–14, 2018.

      [125] A. Heidari, “X–Ray Diffraction (XRD), Powder X–Ray Diffraction (PXRD) and Energy–Dispersive X–Ray Diffraction (EDXRD) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiationâ€, J Oncol Res; 2 (1): 1–14, 2018.

      [126] A. Heidari, “Correlation Two–Dimensional Nuclear Magnetic Reso­nance (NMR) (2D–NMR) (COSY) Imaging and Spectrosco­py Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiationâ€, EMS Can Sci, 1–1–001, 2018.

      [127] A. Heidari, “Thermal Spectroscopy, Photothermal Spectroscopy, Thermal Microspectroscopy, Photothermal Microspectroscopy, Thermal Macrospectroscopy and Photothermal Macrospectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiationâ€, SM J Biometrics Biostat, 3 (1): 1024, 2018.

      [128] A. Heidari, “A Modern and Comprehensive Experimental Biospectroscopic Comparative Study on Human Common Cancers’ Cells, Tissues and Tumors before and after Synchrotron Radiation Therapyâ€, Open Acc J Oncol Med. 1 (1), 2018.

      [129] A. Heidari, “Heteronuclear Correlation Experiments such as Heteronuclear Single–Quantum Correlation Spectroscopy (HSQC), Heteronuclear Multiple–Quantum Correlation Spectroscopy (HMQC) and Heteronuclear Multiple–Bond Correlation Spectroscopy (HMBC) Comparative Study on Malignant and Benign Human Endocrinology and Thyroid Cancer Cells and Tissues under Synchrotron Radiationâ€, J Endocrinol Thyroid Res, 3 (1): 555603, 2018.

      [130] A. Heidari, “Nuclear Resonance Vibrational Spectroscopy (NRVS), Nuclear Inelastic Scattering Spectroscopy (NISS), Nuclear Inelastic Absorption Spectroscopy (NIAS) and Nuclear Resonant Inelastic X–Ray Scattering Spectroscopy (NRIXSS) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiationâ€, Int J Bioorg Chem Mol Biol. 6 (1e): 1–5, 2018.

      [131] A. Heidari, “A Novel and Modern Experimental Approach to Vibrational Circular Dichroism Spectroscopy and Video Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under White and Monochromatic Synchrotron Radiationâ€, Glob J Endocrinol Metab. 1 (3). GJEM. 000514–000519, 2018.

      [132] A. Heidari, “Pros and Cons Controversy on Heteronuclear Correlation Experiments such as Heteronuclear Single–Quantum Correlation Spectroscopy (HSQC), Heteronuclear Multiple–Quantum Correlation Spectroscopy (HMQC) and Heteronuclear Multiple–Bond Correlation Spectroscopy (HMBC) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiationâ€, EMS Pharma J. 1 (1): 002–008, 2018.

      [133] A. Heidari, “A Modern Comparative and Comprehensive Experimental Biospectroscopic Study on Different Types of Infrared Spectroscopy of Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiationâ€, J Analyt Molecul Tech. 3 (1): 8, 2018.

      [134] A. Heidari, “Investigation of Cancer Types Using Synchrotron Technology for Proton Beam Therapy: An Experimental Biospectroscopic Comparative Studyâ€, European Modern Studies Journal, Vol. 2, No. 1, 13–29, 2018.

      [135] A. Heidari, “Saturated Spectroscopy and Unsaturated Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiationâ€, Imaging J Clin Medical Sci. 5 (1): 001–007, 2018.

      [136] A. Heidari, “Small–Angle Neutron Scattering (SANS) and Wide–Angle X–Ray Diffraction (WAXD) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiationâ€, Int J Bioorg Chem Mol Biol. 6 (2e): 1–6, 2018.

      [137] A. Heidari, “Investigation of Bladder Cancer, Breast Cancer, Colorectal Cancer, Endometrial Cancer, Kidney Cancer, Leukemia, Liver, Lung Cancer, Melanoma, Non–Hodgkin Lymphoma, Pancreatic Cancer, Prostate Cancer, Thyroid Cancer and Non–Melanoma Skin Cancer Using Synchrotron Technology for Proton Beam Therapy: An Experimental Biospectroscopic Comparative Studyâ€, Ther Res Skin Dis 1 (1), 2018.

      [138] A. Heidari, “Attenuated Total Reflectance Fourier Transform Infrared (ATR–FTIR) Spectroscopy, Micro–Attenuated Total Reflectance Fourier Transform Infrared (Micro–ATR–FTIR) Spectroscopy and Macro–Attenuated Total Reflectance Fourier Transform Infrared (Macro–ATR–FTIR) Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation with the Passage of Timeâ€, International Journal of Chemistry Papers, 2 (1): 1–12, 2018.

      [139] A. Heidari, “Mössbauer Spectroscopy, Mössbauer Emission Spectroscopy and 57Fe Mössbauer Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiationâ€, Acta Scientific Cancer Biology 2.3: 17–20, 2018.

      [140] A. Heidari, “Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation with the Passage of Timeâ€, Organic & Medicinal Chem IJ. 6 (1): 555676, 2018.

      [141] A. Heidari, “Correlation Spectroscopy, Exclusive Correlation Spectroscopy and Total Correlation Spectroscopy Comparative Study on Malignant and Benign Human AIDS–Related Cancers Cells and Tissues with the Passage of Time under Synchrotron Radiationâ€, Int J Bioanal Biomed. 2 (1): 001–007, 2018.

      [142] A. Heidari, “Biomedical Instrumentation and Applications of Biospectroscopic Methods and Techniques in Malignant and Benign Human Cancer Cells and Tissues Studies under Synchrotron Radiation and Anti–Cancer Nano Drugs Deliveryâ€, Am J Nanotechnol Nanomed. 1 (1): 001–009, 2018.

      [143] A. Heidari, “Vivo 1H or Proton NMR, 13C NMR, 15N NMR and 31P NMR Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiationâ€, Ann Biomet Biostat. 1 (1): 1001, 2018.

      [144] A. Heidari, “Grazing–Incidence Small–Angle Neutron Scattering (GISANS) and Grazing–Incidence X–Ray Diffraction (GIXD) Comparative Study on Malignant and Benign Human Cancer Cells, Tissues and Tumors under Synchrotron Radiationâ€, Ann Cardiovasc Surg. 1 (2): 1006, 2018.

      [145] A. Heidari, “Adsorption Isotherms and Kinetics of Multi–Walled Carbon Nanotubes (MWCNTs), Boron Nitride Nanotubes (BNNTs), Amorphous Boron Nitride Nanotubes (a–BNNTs) and Hexagonal Boron Nitride Nanotubes (h–BNNTs) for Eliminating Carcinoma, Sarcoma, Lymphoma, Leukemia, Germ Cell Tumor and Blastoma Cancer Cells and Tissuesâ€, Clin Med Rev Case Rep 5: 201, 2018.

      [146] A. Heidari, “Correlation Spectroscopy (COSY), Exclusive Correlation Spectroscopy (ECOSY), Total Correlation Spectroscopy (TOCSY), Incredible Natural–Abundance Double–Quantum Transfer Experiment (INADEQUATE), Heteronuclear Single–Quantum Correlation Spectroscopy (HSQC), Heteronuclear Multiple–Bond Correlation Spectroscopy (HMBC), Nuclear Overhauser Effect Spectroscopy (NOESY) and Rotating Frame Nuclear Overhauser Effect Spectroscopy (ROESY) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiationâ€, Acta Scientific Pharmaceutical Sciences 2.5: 30–35, 2018.

      [147] A. Heidari, “Small–Angle X–Ray Scattering (SAXS), Ultra–Small Angle X–Ray Scattering (USAXS), Fluctuation X–Ray Scattering (FXS), Wide–Angle X–Ray Scattering (WAXS), Grazing–Incidence Small–Angle X–Ray Scattering (GISAXS), Grazing–Incidence Wide–Angle X–Ray Scattering (GIWAXS), Small–Angle Neutron Scattering (SANS), Grazing–Incidence Small–Angle Neutron Scattering (GISANS), X–Ray Diffraction (XRD), Powder X–Ray Diffraction (PXRD), Wide–Angle X–Ray Diffraction (WAXD), Grazing–Incidence X–Ray Diffraction (GIXD) and Energy–Dispersive X–Ray Diffraction (EDXRD) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiationâ€, Oncol Res Rev, Volume 1 (1): 1–10, 2018.

      [148] A. Heidari, “Pump–Probe Spectroscopy and Transient Grating Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiationâ€, Adv Material Sci Engg, Volume 2, Issue 1, Pages 1–7, 2018.

      [149] A. Heidari, “Grazing–Incidence Small–Angle X–Ray Scattering (GISAXS) and Grazing–Incidence Wide–Angle X–Ray Scattering (GIWAXS) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiationâ€, Insights Pharmacol Pharm Sci 1 (1): 1–8, 2018.

      [150] A. Heidari, “Acoustic Spectroscopy, Acoustic Resonance Spectroscopy and Auger Spectroscopy Comparative Study on Anti–Cancer Nano Drugs Delivery in Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiationâ€, Nanosci Technol 5 (1): 1–9, 2018.

      [151] A. Heidari, “Niobium, Technetium, Ruthenium, Rhodium, Hafnium, Rhenium, Osmium and Iridium Ions Incorporation into the Nano Polymeric Matrix (NPM) by Immersion of the Nano Polymeric Modified Electrode (NPME) as Molecular Enzymes and Drug Targets for Human Cancer Cells, Tissues and Tumors Treatment under Synchrotron and Synchrocyclotron Radiationsâ€, Nanomed Nanotechnol, 3 (2): 000138, 2018.

      [152] A. Heidari, “Homonuclear Correlation Experiments such as Homonuclear Single–Quantum Correlation Spectroscopy (HSQC), Homonuclear Multiple–Quantum Correlation Spectroscopy (HMQC) and Homonuclear Multiple–Bond Correlation Spectroscopy (HMBC) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiationâ€, Austin J Proteomics Bioinform & Genomics. 5 (1): 1024, 2018.

      [153] A. Heidari, “Atomic Force Microscopy Based Infrared (AFM–IR) Spectroscopy and Nuclear Resonance Vibrational Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation with the Passage of Timeâ€, J Appl Biotechnol Bioeng. 5 (3): 142‒148, 2018.

      [154] A. Heidari, “Time–Dependent Vibrational Spectral Analysis of Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiationâ€, J Cancer Oncol, 2 (2): 000124, 2018.

      [155] A. Heidari, “Palauamine and Olympiadane Nano Molecules Incorporation into the Nano Polymeric Matrix (NPM) by Immersion of the Nano Polymeric Modified Electrode (NPME) as Molecular Enzymes and Drug Targets for Human Cancer Cells, Tissues and Tumors Treatment under Synchrotron and Synchrocyclotron Radiationsâ€, Arc Org Inorg Chem Sci 3 (1), 2018.

      [156] R. Gobato, A. Heidari, “Infrared Spectrum and Sites of Action of Sanguinarine by Molecular Mechanics and ab initio Methodsâ€, International Journal of Atmospheric and Oceanic Sciences. Vol. 2, No. 1, pp. 1–9, 2018.

      [157] A. Heidari, “Angelic Acid, Diabolic Acids, Draculin and Miraculin Nano Molecules Incorporation into the Nano Polymeric Matrix (NPM) by Immersion of the Nano Polymeric Modified Electrode (NPME) as Molecular Enzymes and Drug Targets for Human Cancer Cells, Tissues and Tumors Treatment Under Synchrotron and Synchrocyclotron Radiationsâ€, Med & Analy Chem Int J, 2 (1): 000111, 2018.

      [158] A. Heidari, “Gamma Linolenic Methyl Ester, 5–Heptadeca–5,8,11–Trienyl 1,3,4–Oxadiazole–2–Thiol, Sulphoquinovosyl Diacyl Glycerol, Ruscogenin, Nocturnoside B, Protodioscine B, Parquisoside–B, Leiocarposide, Narangenin, 7–Methoxy Hespertin, Lupeol, Rosemariquinone, Rosmanol and Rosemadiol Nano Molecules Incorporation into the Nano Polymeric Matrix (NPM) by Immersion of the Nano Polymeric Modified Electrode (NPME) as Molecular Enzymes and Drug Targets for Human Cancer Cells, Tissues and Tumors Treatment under Synchrotron and Synchrocyclotron Radiationsâ€, Int J Pharma Anal Acta, 2 (1): 007–014, 2018.

      [159] A. Heidari, “Fourier Transform Infrared (FTIR) Spectroscopy, Attenuated Total Reflectance Fourier Transform Infrared (ATR–FTIR) Spectroscopy, Micro–Attenuated Total Reflectance Fourier Transform Infrared (Micro–ATR–FTIR) Spectroscopy, Macro–Attenuated Total Reflectance Fourier Transform Infrared (Macro–ATR–FTIR) Spectroscopy, Two–Dimensional Infrared Correlation Spectroscopy, Linear Two–Dimensional Infrared Spectroscopy, Non–Linear Two–Dimensional Infrared Spectroscopy, Atomic Force Microscopy Based Infrared (AFM–IR) Spectroscopy, Infrared Photodissociation Spectroscopy, Infrared Correlation Table Spectroscopy, Near–Infrared Spectroscopy (NIRS), Mid–Infrared Spectroscopy (MIRS), Nuclear Resonance Vibrational Spectroscopy, Thermal Infrared Spectroscopy and Photothermal Infrared Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation with the Passage of Timeâ€, Glob Imaging Insights, Volume 3 (2): 1–14, 2018.

      [160] A. Heidari, “Heteronuclear Single–Quantum Correlation Spectroscopy (HSQC) and Heteronuclear Multiple–Bond Correlation Spectroscopy (HMBC) Comparative Study on Malignant and Benign Human Cancer Cells, Tissues and Tumors under Synchrotron and Synchrocyclotron Radiationsâ€, Chronicle of Medicine and Surgery 2.3: 144–156, 2018.

      [161] A. Heidari, “Tetrakis [3, 5–bis (Trifluoromethyl) Phenyl] Borate (BARF)–Enhanced Precatalyst Preparation Stabilization and Initiation (EPPSI) Nano Moleculesâ€, Medical Research and Clinical Case Reports 2.1: 113–126, 2018.

      [162] A. Heidari, “Sydnone, Münchnone, Montréalone, Mogone, Montelukast, Quebecol and Palau’amine–Enhanced Precatalyst Preparation Stabilization and Initiation (EPPSI) Nano Moleculesâ€, Sur Cas Stud Op Acc J. 1 (3), 2018.

      [163] A. Heidari, “Fornacite, Orotic Acid, Rhamnetin, Sodium Ethyl Xanthate (SEX) and Spermine (Spermidine or Polyamine) Nanomolecules Incorporation into the Nanopolymeric Matrix (NPM)â€, International Journal of Biochemistry and Biomolecules, Vol. 4: Issue 1, Pages 1–19, 2018.

      [164] A. Heidari, R. Gobato, “Putrescine, Cadaverine, Spermine and Spermidine–Enhanced Precatalyst Preparation Stabilization and Initiation (EPPSI) Nano Moleculesâ€, Parana Journal of Science and Education (PJSE)–v.4, n.5, (1–14) July 1, 2018.

      [165] A. Heidari, “Cadaverine (1,5–Pentanediamine or Pentamethylenediamine), Diethyl Azodicarboxylate (DEAD or DEADCAT) and Putrescine (Tetramethylenediamine) Nano Molecules Incorporation into the Nano Polymeric Matrix (NPM) by Immersion of the Nano Polymeric Modified Electrode (NPME) as Molecular Enzymes and Drug Targets for Human Cancer Cells, Tissues and Tumors Treatment under Synchrotron and Synchrocyclotron Radiationsâ€, Hiv and Sexual Health Open Access Open Journal. 1 (1): 4–11, 2018.

      [166] A. Heidari, “Improving the Performance of Nano–Endofullerenes in Polyaniline Nanostructure–Based Biosensors by Covering Californium Colloidal Nanoparticles with Multi–Walled Carbon Nanotubesâ€, Journal of Advances in Nanomaterials, Vol. 3, No. 1, Pages 1–28, 2018.

      [167] R. Gobato, A. Heidari, “Molecular Mechanics and Quantum Chemical Study on Sites of Action of Sanguinarine Using Vibrational Spectroscopy Based on Molecular Mechanics and Quantum Chemical Calculationsâ€, Malaysian Journal of Chemistry, Vol. 20 (1), 1–23, 2018.

      [168] A. Heidari, “Vibrational Biospectroscopic Studies on Anti–cancer Nanopharmaceuticals (Part I)â€, Malaysian Journal of Chemistry, Vol. 20 (1), 33–73, 2018.

      [169] A. Heidari, “Vibrational Biospectroscopic Studies on Anti–cancer Nanopharmaceuticals (Part II)â€, Malaysian Journal of Chemistry, Vol. 20 (1), 74–117, 2018.

      [170] A. Heidari, “Uranocene (U(C8H8)2) and Bis(Cyclooctatetraene)Iron (Fe(C8H8)2 or Fe(COT)2)–Enhanced Precatalyst Preparation Stabilization and Initiation (EPPSI) Nano Moleculesâ€, Chemistry Reports, Vol. 1, Iss. 2, Pages 1–16, 2018.

      [171] A. Heidari, “Biomedical Systematic and Emerging Technological Study on Human Malignant and Benign Cancer Cells and Tissues Biospectroscopic Analysis under Synchrotron Radiationâ€, Glob Imaging Insights, Volume 3 (3): 1–7, 2018.

      [172] A. Heidari, “Deep–Level Transient Spectroscopy and X–Ray Photoelectron Spectroscopy (XPS) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiationâ€, Res Dev Material Sci. 7(2). RDMS.000659, 2018.

      [173] A. Heidari, “C70–Carboxyfullerenes Nano Molecules Incorporation into the Nano Polymeric Matrix (NPM) by Immersion of the Nano Polymeric Modified Electrode (NPME) as Molecular Enzymes and Drug Targets for Human Cancer Cells, Tissues and Tumors Treatment under Synchrotron and Synchrocyclotron Radiationsâ€, Glob Imaging Insights, Volume 3 (3): 1–7, 2018.

      [174] A. Heidari, “The Effect of Temperature on Cadmium Oxide (CdO) Nanoparticles Produced by Synchrotron Radiation in the Human Cancer Cells, Tissues and Tumorsâ€, International Journal of Advanced Chemistry, 6 (2) 140–156, 2018.

      [175] A. Heidari, “A Clinical and Molecular Pathology Investigation of Correlation Spectroscopy (COSY), Exclusive Correlation Spectroscopy (ECOSY), Total Correlation Spectroscopy (TOCSY), Heteronuclear Single–Quantum Correlation Spectroscopy (HSQC) and Heteronuclear Multiple–Bond Correlation Spectroscopy (HMBC) Comparative Study on Malignant and Benign Human Cancer Cells, Tissues and Tumors under Synchrotron and Synchrocyclotron Radiations Using Cyclotron versus Synchrotron, Synchrocyclotron and the Large Hadron Collider (LHC) for Delivery of Proton and Helium Ion (Charged Particle) Beams for Oncology Radiotherapyâ€, European Journal of Advances in Engineering and Technology, 5 (7): 414–426, 2018.

      [176] A. Heidari, “Nano Molecules Incorporation into the Nano Polymeric Matrix (NPM) by Immersion of the Nano Polymeric Modified Electrode (NPME) as Molecular Enzymes and Drug Targets for Human Cancer Cells, Tissues and Tumors Treatment under Synchrotron and Synchrocyclotron Radiationsâ€, J Oncol Res; 1 (1): 1–20, 2018.

      [177] A. Heidari, “Use of Molecular Enzymes in the Treatment of Chronic Disordersâ€, Canc Oncol Open Access J. 1 (1): 12–15, 2018.

      [178] A. Heidari, “Vibrational Biospectroscopic Study and Chemical Structure Analysis of Unsaturated Polyamides Nanoparticles as Anti–Cancer Polymeric Nanomedicines Using Synchrotron Radiationâ€, International Journal of Advanced Chemistry, 6 (2), 167–189, 2018.

      [179] A. Heidari, “Adamantane, Irene, Naftazone and Pyridine–Enhanced Precatalyst Preparation Stabilization and Initiation (PEPPSI) Nano Moleculesâ€, Madridge J Nov Drug Res. 2 (1): 61–67, 2018.

      [180] A. Heidari, “Heteronuclear Single–Quantum Correlation Spectroscopy (HSQC) and Heteronuclear Multiple–Bond Correlation Spectroscopy (HMBC) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiationâ€, Madridge J Nov Drug Res, 2 (1): 68–74, 2018.

      [181] A. Heidari, R. Gobato, “A Novel Approach to Reduce Toxicities and to Improve Bioavailabilities of DNA/RNA of Human Cancer Cells–Containing Cocaine (Coke), Lysergide (Lysergic Acid Diethyl Amide or LSD), Δâ¹â€“Tetrahydrocannabinol (THC) [(–)–trans–Δâ¹â€“Tetrahydrocannabinol], Theobromine (Xantheose), Caffeine, Aspartame (APM) (NutraSweet) and Zidovudine (ZDV) [Azidothymidine (AZT)] as Anti–Cancer Nano Drugs by Coassembly of Dual Anti–Cancer Nano Drugs to Inhibit DNA/RNA of Human Cancer Cells Drug Resistanceâ€, Parana Journal of Science and Education, v. 4, n. 6, pp. 1–17, 2018.

      [182] A. Heidari, R. Gobato, “Ultraviolet Photoelectron Spectroscopy (UPS) and Ultraviolet–Visible (UV–Vis) Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiationâ€, Parana Journal of Science and Education, v. 4, n. 6, pp. 18–33, 2018.

      [183] R. Gobato, A. Heidari, A. Mitra, “The Creation of C13H20BeLi2SeSi. The Proposal of a Bio–Inorganic Molecule, Using Ab Initio Methods for the Genesis of a Nano Membraneâ€, Arc Org Inorg Chem Sci 3 (4). AOICS.MS.ID.000167, 2018.

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      [186] A. Heidari, “Bastadins and Bastaranes–Enhanced Precatalyst Preparation Stabilization and Initiation (EPPSI) Nano Moleculesâ€, Glob Imaging Insights, Volume 3 (4): 1–7, 2018.

      [187] A. Heidari, “Fucitol, Pterodactyladiene, DEAD or DEADCAT (DiEthyl AzoDiCArboxylaTe), Skatole, the NanoPutians, Thebacon, Pikachurin, Tie Fighter, Spermidine and Mirasorvone Nano Molecules Incorporation into the Nano Polymeric Matrix (NPM) by Immersion of the Nano Polymeric Modified Electrode (NPME) as Molecular Enzymes and Drug Targets for Human Cancer Cells, Tissues and Tumors Treatment under Synchrotron and Synchrocyclotron Radiationsâ€, Glob Imaging Insights, Volume 3 (4): 1–8, 2018.

      [188] E. Dadvar, A. Heidari, “A Review on Separation Techniques of Graphene Oxide (GO)/Base on Hybrid Polymer Membranes for Eradication of Dyes and Oil Compounds: Recent Progress in Graphene Oxide (GO)/Base on Polymer Membranes–Related Nanotech

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    Heidari, A., & Peterson, V. (2020). A comprehensive review on functional roles of cancerous immunoglobulins and potential applications in cancer immunodiagnostics and immunotherapy. International Journal of Advanced Chemistry, 8(1), 44-58. https://doi.org/10.14419/ijac.v8i1.30500

    Received date: 2020-03-06

    Accepted date: 2020-03-23

    Published date: 2020-04-18