Kinetics and mechanism of oxidation of cetirizine hydrochloride, an anti-allergy agent by Mn(VII) in acidic medium

  • Authors

    • J. Panda
    • Ajaya Kumar Patnaik Ravenshaw University
    • G. C. Pradhan
    • P. Mohanty
    2014-08-24
    https://doi.org/10.14419/ijac.v2i2.3130

  • Abstract

    The kinetics and mechanism of oxidation of cetirizine hydrochloride by Mn(VII) in acidic medium was studied spectrophotometrically. The electron transfer reaction between MnO4- and the drug have been studied over the range 2.0 ? 103 [cetirizine hydrochloride] ? 6.0, 2.5 ? pH ? 4.5 and 295 K ? T ? 313 K in aqueous medium. The electron transfer reaction shows first order dependence in [MnO4-] T and [cetirizine hydrochloride]. The rate of the reaction was found to increase with increasing pH of the medium. The conjugate base of the reactant drug and MnO4- reacts to produce products. The activation parameters ?H? (kJ mol-1) and ?S? (JK-1 mol-1) for the electron transfer reaction was found to be 33.93 and -143.00. The product of the reaction was cetirizine N-oxide.

    Keywords: Cetirizine, Oxidation, Kinetics, Cetirizine N-Oxide, Spectrophotometer.

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  • How to Cite

    Panda, J., Patnaik, A. K., Pradhan, G. C., & Mohanty, P. (2014). Kinetics and mechanism of oxidation of cetirizine hydrochloride, an anti-allergy agent by Mn(VII) in acidic medium. International Journal of Advanced Chemistry, 2(2), 124-129. https://doi.org/10.14419/ijac.v2i2.3130

    Received date: 2014-07-07

    Accepted date: 2014-08-10

    Published date: 2014-08-24