Synthesis of Nitrogen-Containing Chalcone Via One-Pot Three-Component Reaction . part ii
Keywords:Chalcone, 3-Hydroxybenzaldehyde, 4-Methoxyacetophenone, Aminomethylation, Formaldehyde, N-Methylpiperazine.
The compound 3-Hydroxy-4'-methoxychalcone (1) was prepared by reacting 3-hydroxybenzaldehyde with 4-methoxyacetophenone.
The aminomethylation of this chalcone was accomplished by reaction with formaldehyde and N-methylpiperazine in dry acetonitrile to Obtain 3-hydroxy-4'-methoxy-4-(N-methyl-piperazinomethyl) chalcone (2) and 3-hydroxy-4'-methoxy-2,4-bis-(N-methylpiperazinomethyl)chalcone(3). The products were purified by column and thin layer chromatography and were identified along with their intermediates by spectroscopic methods: UV, IR, NMR and mass spectrometry.
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