Spectral characterization, microbial activities and toxicity study of some newly synthesized hydrazone derivatives

  • Authors

    • N. Kalaiarasi Research scholar
    • S. Manivarman Assistant Professor
    2017-06-22
    https://doi.org/10.14419/ijac.v5i2.7739

  • Abstract

    Hydrazone derivatives of 2-Thioxodihyropyrimidine-2-dione were synthesized by addition of thiobarbituric acid with phenyl hydrazine, dinitrophenyl hydrazine, semicarbazide, thiosemicarbazide and benzohydrazide respectively. Structures of these synthesized compounds are characterized by means of UV, IR, Proton-NMR, Carbon- NMR. Finally the hydrazone derivatives synthesized are screened for biological activities namely antibacterial and antifungal activities. Also in addition the toxicity studies of the compounds are also performed.

  • References

    1. [1] Kratz F., Beyer U., Collery P., 1998, Preparation, Characterization and in Vitro Efficacy of Albumin Conjugates of Doxorubicin, Biological & Pharmaceutical Bulletin, 21, 1, 56 - 61. https://doi.org/10.1248/bpb.21.56.

      [2] Imramovsky A., Polanc S., Kaustova J., 2007, A new modification of anti-tubercular active molecules, Bioorganic Medicinal Chemistry., 15, 7, 2551-2559. https://doi.org/10.1016/j.bmc.2007.01.051.

      [3] Janin Y. L., 2007, Antituberculosis drugs: Ten years of research, Bioorganic Medicinal Chemistry., 15, 7, 2479 - 2513. https://doi.org/10.1016/j.bmc.2007.01.030.

      [4] Salgin-Goksen U., Gokham-Keleci N., Goktas O., 2007, 1-Acylthiosemicarbazides, 1,2,4-triazole-54H-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: Synthesis, analgesic-anti-inflammatory and antimicrobial activities, Bioorganic Medicinal Chemistry., 15, 17, 5738 – 5751. https://doi.org/10.1016/j.bmc.2007.06.006.

      [5] Bhalla A., Sharma N., Jain S., 2006, HIV immunosupression and malaria: Is there a correlation, Indian Journal of Medical Sciences., 60, 9,376.

      [6] Silva G.A., Costa L. M. M., Brito F. C. F., Fraga A.M., 2004, New class of potent antinociceptive and antiplatelet 10H-phenothiazine-1-acylhydrazone derivatives, Bioorganic Medicinal Chemistry., 12, 12, 3149-3158. https://doi.org/10.1016/j.bmc.2004.04.009.

      [7] Savini L., Chiasserini L., Travagli V., Pellerano C., 2004, New α-N-Heterocyclic hydrazones: Evaluation of Anticancer, anti-HIV, and Antimicrobial Activity, Chem Informatics., 35, 29. https://doi.org/10.1002/chin.200429138.

      [8] Bijev A., 2006, New Heterocyclic Hydrazones in the Search for Antitubercular Agents: Synthesis and In Vitro Evaluations, Letters Drug Design & Discovery., 3, 7, 506 - 512.

      [9] Abdel- Aal M. T., El - sayed W. A., 2006, Synthesis and Antiviral Evaluation of Some Sugar Arylglycinoylhydrazones and Their Oxadiazoline Derivatives, Archiv der Pharmazie., 339, 12, 656 - 663.

      [10] El-Hawash S.A.M., Abdel W.A.E., 2006, Cyanoacetic Acid Hydrazones of 3-and 4-Acetylpyridine and Some Derived Ring Systems as Potential Antitumor and Anti-HCV Agents, Archiv der Pharmazie., 339, 1, 14 - 23. https://doi.org/10.1002/ardp.200500161.

      [11] Cocco M.T., Congiu C., Lilliu V., Onnis V., 2005, New Potential Anticancer Agents Based on the Anthranilic Acid Scaffold. Synthesis and Evaluation of Biological Activity, Journal of Medicinal Chemistry, 48, 26, 8245-8252. https://doi.org/10.1021/jm050711d.

      [12] Malhotra M., Sharma R., Rathee D., Phogat P., 2014, Benzylidene /2-aminobenzylidene hydrazides: Synthesis, characterization and in vitro antimicrobial evaluation, Arabian Journal of Chemistry., 7, 5, 666 - 671. https://doi.org/10.1016/j.arabjc.2010.11.016.

      [13] Long D. A., 2004, Infrared and Raman characteristic group frequencies. Journal of Raman Spectroscopy., 35, 10, 905.

      [14] Wong K. C., 2015, Review of Spectrometric Identification of Organic Compounds, 8th Edition Spectrometric Identification of Organic Compounds, Journal of Chemical Education., 92, 10, 1602 – 1603.

      [15] Bauer A.W., Kirby W. M. M., Sherris J.C., Truck. M., 1966, Quality Control Testing with the Disk Antibiotic Susceptibility Test of Bauer–Kirby–Sherris–Turck, American Journal of Clinical Pathology, 45, 493-496.

      [16] Mossman T., 1983, Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays, Journal of Immunological Methods., 65, 1-2, 55-63. https://doi.org/10.1016/0022-1759(83)90303-4.

      [17] Alley M.C., Lieber M.M., 1984, improved optical detection of colony enlargement and drug cytotoxicity in primary soft agar cultures of human solid tumour cells, British Journal of Cancer Research., 49, 2, 225-233. https://doi.org/10.1038/bjc.1984.35.

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    Kalaiarasi, N., & Manivarman, S. (2017). Spectral characterization, microbial activities and toxicity study of some newly synthesized hydrazone derivatives. International Journal of Advanced Chemistry, 5(2), 54-60. https://doi.org/10.14419/ijac.v5i2.7739

    Received date: 2017-05-06

    Accepted date: 2017-06-05

    Published date: 2017-06-22