Lowering blood sugar levels with kersen leaf stew (muntingia calabura l) and black onion (alium sativum) extract in mice (mus musculus)
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2020-03-06 https://doi.org/10.14419/ijans.v9i1.30304 -
Diabetes Mellitus, Kersen Leaf, Black Onion Extract, Blood Glucose Level, Mice (Mus Musculus). -
Abstract
Diabetes mellitus (DM) is a metabolic disease characterized by an increase in blood sugar levels. Blood sugar levels in patients with DM are mostly challenging to control, and this will threaten the occurrence of complications. Alternative therapies used are active flavonoids in reducing blood glucose. The purpose of this study was to analyze the decrease in blood sugar levels by administering cherry leaves stew and black onions to mice (mus musculus). The design of this study was the Quasy Experimental design (pretest-posttest with control group design). The sample in this study was 32 mice, 16 in the intervention group, and 16 comparison groups. There are independent variables (Kersen Leaf Stew and Black Onion Extract) and the dependent variable (Blood Glucose Level). The data were collected using an observation sheet, then analyzed using the independent sample T-test and Kolmogorov Smirnov test. The results of this study showed that the pre and post administration of cherry leaf decoction was 36.5 mg/dl, and the difference between pre and post administration of black onion extract was 24.3 mg/dl. While the analysis showed p = value 0.98, it showed no difference in the effectiveness of the two extracts in reducing blood sugar levels in mice. Obtained comparative test results from the two extracts were equally effective in lowering blood sugar in mice. Thus further research needs to be done with more samples.
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References
[1] N. J. Masfufah, Veni Hadju, “Pengetahuan, Kadar Glukosa Darah, Dan Kualitas Hidup Penderita Diabetes Mellitus Tipe 2 Rawat Jalan Di Wilayah Kerja Puskesmas Kota Makassar,†Universitas Hasanuddin, 2013.
[2] Riset Kesehatan Dasar, Badan Penelitian dan Pengembangan Kesehatan. Jakarta: Kementrian Kesehatan RI, 2015.
[3] M. Taufik Perwira Wicaksono, “Diabetes mellitus tipe II gula darah tidak terkontrol dengan komplikasi neuropati diabetikum,†Medula, vol. 1, no. 3, 2013.
[4] P. S. Barrat E, Zaïr Y, Ogier N, Housez B, Vergara C, Maudet C, Lescuyer JF, Bard JM, Carpentier YA, Cazaubiel M, “A combined natural supplement lowers LDL cholesterol in subjects with moderate untreated hypercholesterolemia: a randomized placebo-controlled trial,†Int J Food Sci Nutr, vol. 64, no. 7, pp. 882–9, 2013. https://doi.org/10.3109/09637486.2013.809405.
[5] M. M. Zahroh R., “Rebusan daun kersen menurunkan kadar gula darah pada pasien diabetes melitus tipe 2,†J. Ners Community, vol. 7, no. 2, pp. 125–135, 2016.
[6] S. W. Jung, E. S., Park, S. H., Choi, E. K., Ryu, B. H., Park, B. H., Kim, D. S., Kim, Y. G., & Chae, “Reduction of blood lipid parameters by a 12-wk supplementation of aged black garlic:a randomized controlled trial. Nutrition,†Nutrition, vol. 30, no. 9, 2014. https://doi.org/10.1016/j.nut.2014.02.014.
[7] O. C. Kim, J. S., Kang, O. J., & Gweon, “Comparison of phenolic acids and flavonoids in black garlic at different thermal processing step,†J. Funct. Foods, vol. 5, no. 1, pp. 80–86, 2013. https://doi.org/10.1016/j.jff.2012.08.006.
[8] B. . Rizky, “White Dragon Fruit (Hylocereus undatus) Potential As Diabetes Mellitus Treatment,†Med. J. LAMPUNG Univ., vol. 4, no. 1, pp. 69–72, 2015.
[9] A. A. A. Hidayat, Metodologi Penelitian Kesehatan. Surabaya: Health Books Publishing, 2010.
[10] Gutierrez MJ et al, “Efficacy and safety of ETC-1002, a novel investigational low-density lipoprotein-cholesterol-lowering therapy for the treatment of patients with hypercholesterolemia and type 2 diabetes mellitus,†Arter. Thromb Vasc Biol., vol. 34, no. 3, pp. 676–83, 2014. https://doi.org/10.1161/ATVBAHA.113.302677.
[11] American Diabetes Association, “Diabetes Mellitus and Exercise,†Diabetes Care, vol. 25, no. 1, 2010.
[12] A. . Potter, P.A. & Perry, Fundamental of nursing : concepts, process, ad practice. St.Louis: Mosby Company, 2009.
[13] W. Makalalag, I.W. Wullur, A. Adeanne dan Wiyono, “Uji Ekstrak Daun Binahong (Anredera cordifolia (Ten) Steenis) Terhadap Kadar Gula Darah Pada Tikus Putih Jantan Galur Wistar ( Rattus norvegicus) yang diinduksi Sukrosa,†J. Ilm. Farm., vol. 2, no. 1, 2013.
[14] W. wiyono Indri Wirasuasty Makalalag, Adeanne Wullur, “Uji Ekstrak Daun Binahong ( Anredera cordifolia Steen.) Terhadap kadar Gula Darah Pada Tikus Putih Jantan Galur Wistar ( Rattus norvegicus) yang Diinduksi Sukrosa,†Pharmacon, vol. 2, no. 1, 2013.
[15] Rosita, “Pengaruh Ekstrak Bawang Hitam (Black Garlick) Tehadap Penurunan Kadar Gula darah pada Mencit (mus musculus) Berdasarkan Lama Pemanasan,†Akademi Analis Farmasi dan Makanan Putra Indonesia Malang, 2016.
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How to Cite
Sumarliyah, E., Nasrullah, D., ., S., & Pankyano, D. (2020). Lowering blood sugar levels with kersen leaf stew (muntingia calabura l) and black onion (alium sativum) extract in mice (mus musculus). International Journal of Advanced Nursing Studies, 9(1), 15-19. https://doi.org/10.14419/ijans.v9i1.30304Received date: 2020-01-10
Accepted date: 2020-02-12
Published date: 2020-03-06