Gene selection in Cox regression model based on a new adaptive penalized method

  • Authors

    • Oday Isam Alskal University of Mosul
    • Zakariya Yahya Algamal University of Mosul
    2020-05-15
    https://doi.org/10.14419/ijasp.v8i1.30566
  • Cox Regression Model, Penalized Method, LASSO, Gene Selection.

  • Abstract

    The common issues of high dimensional gene expression data for survival analysis are that many of genes may not be relevant to their diseases. Gene selection has been proved to be an effective way to improve the result of many methods. The Cox proportional hazards regression model is the most popular model in regression analysis for censored survival data. In this paper, an adaptive penalized Cox proportional hazards regression model is proposed, with the aim of identification relevant genes and provides high classification accuracy, by combining the Cox proportional hazards regression model with the weighted least absolute shrinkage and selection operator (LASSO) method. Experimental results show that the proposed method significantly outperforms two competitor methods in terms of the area under the curve and the number of the selected genes.

     

     

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  • Received date: 2020-03-27

    Accepted date: 2020-05-07

    Published date: 2020-05-15