Comparative clinical competence of two commercial injectable ivermectin against caprine haemonchosis (Haemonchus contortus)

  • Authors

    • Md Akanda Sylhet Agricultural University, Bangladesh
    • Md Islam Sylhet Agricultural University, Bangladesh
    • Md Hossain Sylhet Agricultural University, Bangladesh
    • Abdullah Al Masud Sylhet Agricultural University, Bangladesh

    Received date: July 30, 2014

    Accepted date: August 30, 2014

    Published date: September 3, 2014

    https://doi.org/10.14419/ijbr.v2i2.3296

  • Abstract

    The foremost purpose of the study reported here was to perform a pharmacological evaluation of two different injectable ivermectin formulations in goats infected with haemonchosis. Twenty one (n=21) goats were randomly divided into three groups A, B and C whereas each group consisted of seven (n=7) goats. Product A and Product B were injected subcutaneously to the goat in group A and group B, respectively. Goat in group C was kept as infected control group giving any treatment. With 7th, 14th, 21th and 28th days of treatment, a significantly (P<0.01) decreased of egg per gram (EPG) count was found in treated goat of group A and B, respectively. In ex­perimental period, the EPG count of control group C were significantly (P<0.01) increased. In group A and B reduction of mean EPG on 7th, 14th, 21th and 28th day after treatment were 83.9%-80.8%, 81.7%-80.7, 78.1%-77.0% and 73.7%-61.2%, respectively, whereas in control group C the mean EPG were 6.7%, 9.2%, 21.4% and 30.9%, respectively. The body weight was increased signifi­cantly (P<0.01) after treatments in group A and B, respectively except untreated control group C. To sum up, two commercial products contain ivermectin have similar clinical competence against haemonchosis in goat.

    Keywords: Clinical Competence, Goat, Ivermectin, Haemonchosis.

  • References

    1. Baggherwal RK, Sisodia RS and Ghosal SB (1991). Efficacy of Ivermectin against naturally acquired nematodiasis in goats with special reference to its residual effect. Indian Vet. Med. J., 15:291-292.
    2. Docastro M and Cocuzza U (1995). Efficacy of Ivermectin in reducing gastrointestinal nematode fecal egg counts in goat in Burundi. Preventive Veterinary Medicine, 23:173-178. http://dx.doi.org/10.1016/0167-5877 (94)00441-K.
    3. Islam MA and Samad MA (1989). Efficacy of commercial fascioli¬cides against mixed infection of fascioliasis and amphisto¬miasis in cattle. Bangladesh Vet, 6, 27-32.
    4. Mortensen LL, Williamson LH, Terrill TH, Kircher R, Larsen M and Kaplan RM (2003). Evaluation of prevalence and clinical implications of anthelmintic resistance in gastrointestinal nematodes of goats. JAVMA 23:495–500 http://dx.doi.org/10.2460/javma.2003.223.495.
    5. Mooney L, Good B, Hanrahan JP, Mulcahy G and De Waal T (2009). The comparative efficacy of four anthelmintics against a natural acquired Fasciola hepatica infection in hill sheep flock in the west of Ireland. Vet Parasitol, 164, 201-205. http://dx.doi.org/10.1016/j.vetpar.2009.05.017.
    6. Mukherjee R, Laha R, Bhattacharya D and Reena M (1994). Comparative efficacy of tetramisole, Fenbendazole and Ivermectin against gastrointestinal nematode infection in Pashmina (Cashmere) goats. Indian J. Anim. Health, 33:125 -127.
    7. Ponikarov AV (1989). Efficacy of Ivomec-F injection in sheep. By Uleten-Vesesoyunogo-Instituta-Gelmintologi-im,-K--Kryabina, 52:86.
    8. Ram HTJ, Rasool AK, Sharma HR and Meena SK (2007). Comparative efficacy of different anthelmintic against fenbendazole - resistant nematode of pashmina goat. Vet. Res. Commun. 31, 719-723. http://dx.doi.org/10.1007/s11259-007-0021-8.
    9. Rodistis OM, Gay CC, Blood DC and Hinchcliff KW (2000). Veteri¬nary Medicine, ninth edition, Harcourt Publishers, London, UK, pp; 1339-1342.
    10. Russel DF (1996). MSTAT Director. Crop and soil science de¬partment, Michigan state university, USA.
    11. Shastri UV (1989). Efficacy of ivermectin against gastrointestinal nematodiasis infection in goat. Indian Vet. J., 66:345-346.
    12. Vatta AF, Letty BA, van der Linde MJ, vanWijk EF, Hansen JW and Krecek RC (2001).Testing for clinical anaemia caused by haemonchus spp. in goats farmed under resource -poor conditions in South Africa using an eye color chart developed for sheep, Vet. Parasitol. 99: 1–14. http://dx.doi.org/10.1016/S0304-4017 (01)00446-0.
    13. Waller P (2003). Global perspectives on nematode parasite control in ruminant livestock: the need to adopt alternatives to chemotherapy, with emphasis on biological control. Anim Health Res Rev, 4:35-44. http://dx.doi.org/10.1079/AHRR200350.
    14. Yadav CL, Ghouri SK, Singh BP and Sharma MC (1996). Benzimidazole resistance in Haemonchus contortus of sheep and goats in Uttar Pradesh in India. J. Vet. parasitology,10:47-51
    15. Yadav CLl, Uuppal RP and kalra SI (1993). An outbreak of haemonchosis associated with anthelmintic resistance in sheep. Int. J. Parasitol. 23, 411-413. http://dx.doi.org/10.1016/0020-7519 (93)90019-U.
    16. Yuliang J and Zang DB (1997). Epidemiological survey of Fasciolia¬sis in Pakistan. Trop J Parasitol, 48, 302-303.

  • Downloads

  • How to Cite

    Akanda, M., Islam, M., Hossain, M., & Al Masud, A. (2014). Comparative clinical competence of two commercial injectable ivermectin against caprine haemonchosis (Haemonchus contortus). International Journal of Biological Research, 2(2), 96-98. https://doi.org/10.14419/ijbr.v2i2.3296

    Received date: July 30, 2014

    Accepted date: August 30, 2014

    Published date: September 3, 2014