Comparative efficacy of Albendazole, Fenbendazole and Levamisole against gastrointestinal nematodiasis in cattle of Bangladesh

  • Authors

    • Monirul Islam Department of Pharmacology, Faculty of Veterinary and Animal Science, Sylhet Agricultural University, Sylhet.
    • Siddiqul Islam Department of Pharmacology, Faculty of Veterinary and Animal Science, Sylhet Agricultural University, Sylhet.
    • Matiar Howlader Department of Physiology, Faculty of Veterinary and Animal Science, Sylhet Agricultural University, Sylhet.
    • Nasrin Lucky Department of Surgery and Theriogenology, Faculty of Veterinary and Animal Science, Sylhet Agricultural University, Sylhet.
    2015-03-17
    https://doi.org/10.14419/ijbr.v3i1.4301
  • Anthelmintics, Cattle, Gastrointestinal Helminths, Heamatological Parameters, Nematodiasis.

  • Abstract

    Out of 52 cattle 30 were heavily infested with different gastrointestinal nematodes which were identified by faecal examination. Among 30 cattle 20 were selected randomly and divided into four groups (A, B, C and D). Group D was kept as infected control group. Group A, B and C were treated with patent drug Albendazole (Helmex-vet® 600 mg/Tab) 7.5, Fenbendazole (Peraclear® 250 mg/bolus) 7.5 and Levamisole (Ralnex® 708 mg/bolus) 7.5 mg/kg body weight orally for the determination of effects on blood parameters. Before trials with Helmex-vet®, Peraclear® and Ralnex® initial total egg count of gastrointestinal helminths and haematological parameters were examined and recorded. During the experimental period the faecal samples were examined on 7th, 14th, 21st and 28th day. Haematological parameters (TEC, Hb, ESR, TLC and PCV) were also examined from 7 to 28 days for the determination of effects of Helmex-vet®, Peraclear® and Ralnex®. A significant reduction of EPG of gastrointestinal nematodes were found on 7th, 14th, 21st and 28th day of Helmex-vet® (46.91%, 72.84%, 84.44% and 93.58%), Peraclear® (46.67%, 71.67%, 83.33% and 90.56%) and Ralnex® (49.27%, 72.82%, 93.93% and 85.80%) of group A, B and C respectively. The EPG of untreated group were significantly increased about 3.37%, 6.75%, 8.13% and 9.69% on 7th, 14th, 21st and 28th day respectively. After treatment with Helmex-vet®, Peraclear® and Ralnex®, TEC, Hb, TLC and PCV were increased and ESR were decreased in cattle. On the other hand, TEC, Hb, TLC and PCV were decreased and ESR was increased significantly (p<0.05) in untreated group.

  • References

    1. [1] Ahmed M & Ansari JA (1989) Effect of Haemonchosis on hematology and non-specific Phosphomonoesterase activities in sheep and goats. Helminthology 26(4), 295-302.

      [2] Ahmed R (1972) parasitic picture and livestock productivity in East Pakistan. In: Activities of the Research section of Directorate of livestock Services, Bangladesh 2, and 32-35.

      [3] Akbaev MS (1986) Blood picture of sheep infected with Moniezia expansa. Moskovskaya Veteinarnaya Akademiya 3, 287-290.

      [4] Amin MR, Khalid SMA, Alam MO, Mostofa M, Paul BK & Shahiduzzaman M (2005) Effects of Helmex and Peraclear? Against Gastro-Intestinal Nematodiasis in Sheep. Journal of Animal and Veterinary Advances 4(1), 58-62.

      [5] Anwar AH, Hayet CS & Amir MI (1996) Prevalence of gastro-intestinal helminthiasis and comparative efficacy of anthelmintics in parasitizded buffalo calves. Pakistan Veterinary Journal 16(4), 160-163.

      [6] Asian development Bank-ADB (1984) Annual report on agricultural development. Livestock Sector 24(7).

      [7] Atanásio A, Boomker J & Sitoe C (2002) A survey on the occurrence of resistance to anthelmintics of gastrointestinal nematodes of goats in Mozambique. Onderstepoort Journal of Veterinary Research 69(3), 215-20.

      [8] Beck AAH, Beck AA & Moreira WS (1991) Levamisole in sheep. Revistadocenteo da ciecias Russis 1,113-120.

      [9] Bhuiyan AKFH (2007) Cattle and livelihood in Bangladesh. Article from web resource. http://www.vishwagou. org/ date 02/09/2008.

      [10] Borgsteed FHM (1979) the activity of Albendazole against adult and larval gastro-intestinal nematodes in naturally infected calves in the Netherlands. Veterinary Quarterly report 1(4), 181-188.

      [11] Craig TM & Bell RR (1978) Evolution of Levamisole and Fenbendazole as an anthelmintic for gastro-intestinal nematodes of cattle. American Journal of Veterinary Research 39(6), 1037-1038.

      [12] Debnath NC, Taimur AK, Saha M, Ersaduzaman M, Heleluddin ML, Rahman DK, Roy MJFA & Islam MA (1995) A retrospective study of calf losses on the central dairy cattle breeding station in Bangladesh. Prev Vet Med. 24, 43–53. http://dx.doi.org/10.1016/0167-5877(95)00471-8.

      [13] Demeler J, Van Zeveren AM, Kleinschmidt N, Vercruysse J, Höglund J, Koopmann R, Cabaret J, Claerebout E, Areskog M & von Samson-Himmelstjerna G (2009) Monitoring the efficacy of ivermectin and albendazole against gastro intestinal nematodes of cattle in Northern Europe. Veterinary Parasitology 160(1-2), 109-15. http://dx.doi.org/10.1016/j.vetpar.2008.10.030.

      [14] DLS (2007-2008) Livestock conservation and development program, Directorate of Livestock Services, Farmgate, Dhaka, Bangladesh.

      [15] Dzakula AN, Rapic D & Zukovic M (1985) Efficacy of albendazole, (Monil) against gastro-intestinal nematodes and liver flukes in cattle and sheep. Praxiz Veterinaia 33(1-2), 167-171.

      [16] Economic index (2010) Finance division, Ministry of Finance, Government of the People Republic of Bangladesh, www.mof.gov.bd

      [17] Fitzimmons WM, Harness EI & Sellwoojd SA (1968) Experimental TrichoTrichuris spp. infection in adult goats. Res. Vet. Sci 9(3), 237-247.

      [18] Gupta SP (1978) Statistical method 1st Ed. Sulton Chand and Sons Pub. Daryangang. New-Delhi 110002, India.

      [19] Hosking BC, Stein PA, Mosimann D, Seewald W, Strehlau G & Kaminsky R (2008) Dose determination studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep Veterinary Parasitology 157(1-2), 72-80. http://dx.doi.org/10.1016/j.vetpar.2008.07.014.

      [20] Jagannath MSD, Sonza PE & Rahman AS (1988) Clinical trials with fenbendazole against strongyle infection in dairy cattle. Livestock Adv 13, 39-41.

      [21] Maqbool A, Rahman F & Afzal M (1996) Comparative anthelmintic efficacy of fenbendazole, tetramisole and morantel tartrate against ascariasis in buffalo calves. Buffalo Journal 12, 343-346.

      [22] Mason JL & Buramendram V (1982) Breeding plans for ruminant livestock in the tropics. FAO, Animal Production and Health paper 136, 34-89.

      [23] Mortensen LL, Williamson LH, Terrill TH, Kircher RA, Larsen M & Kaplan RM (2003) Evaluation of prevalence and clinical implications of anthelmintic resistance in gastrointestinal nematodes in goats. Journal of American Vetetrinary Medical Association 223(4), 495-500. http://dx.doi.org/10.2460/javma.2003.223.495.

      [24] Motalib MA & Alam MS (1983) the possible economic effect of gastro-intestinal nematodes in young cattle in Pabna Milk-shed, Area of Bangladesh. Bangladesh Veterinary Journal 17(1-4), 5-9.

      [25] Mukherjee BN (1992) Efficacy of Albendazole against gastro-intestinal nematodes in naturally infected calves. Indian Veterinary Medical Journal 16(4), 292-295.

      [26] Nettleton D & Beckett P (1976) Hematology of the indigenous goat in Switzerland. Tropical Animal Health and Production 8, 60-61. http://dx.doi.org/10.1007/BF02383368.

      [27] Nwosu CO, Eneme TA, Onyeyili PA & Ogugbuaja VO (2007) Toxicity and anthelmintic efficacy of crude aqueous of extract of the bark of Sacoglottis gabonensis. Fitoterapia 79(2), 101-5. http://dx.doi.org/10.1016/j.fitote.2007.07.010.

      [28] Ogunsusi RA (1978) Changes in Blood value of sheep suffering from acute and chronic helminthes. Research in Veterinary Science 25(3), 298-301.

      [29] Partani AK, Kumar D, Manoha, GS & Kumar R (1995) Comparative efficacy of some anthelmintics against gastro-intestinal nematodes in camel. Journal of Camel Practice and Research 2, 97-99.

      [30] Prodhan KB, Thakur DK & Sudham NA (1991). Haemato-biochemical changes in calves with natural helminthic infection in Ranchi. J. Res. Agric. University. 3 (1), 119-121.

      [31] Prodhan KB, Thakur DK & Sudham NA (1993) Comparative efficacy of ivermectin and Levamisole hydrochloride against nematodiasis in calves. Journal of Research, Birsa Agricultural University 5(2), 187-189.

      [32] Qadir ANMA (1981) a preliminary study on the epidemiology of Fascioliasis in goats. Bangladesh Veterinary Journal 15, 13-17.

      [33] Rahman MH & Razzak A (1973) Incidence of helminth parasites infecting cattle Kotwali Thana of Comilla. First Bangladesh Veterinary Conference in Agricultural University Campus, Mymensingh, pp. 25.

      [34] Sahia BN (1966) Studies in blood picture in stomach worm infection in sheep and goats. Indian Veterinary Journal 43(5), 422-426.

      [35] Samanta A & Santra PK (2009). Prevalence of gastrointestinal helminthes in hot and humid zone of West Bengal. Journal of Veterinary Parasitology 23 (1), 50-55.

      [36] Serikbaeva BK (1981) Pathological and immunological change during Trichostrongylus and Haemonchus infection in sheep. Vostochnoe otdelenic Voskhnil, pp. 122-130.

      [37] Shahiduzzaman AKM, Talukder MH & Rahman MH (1999) Ecology of periphrastic stages of Strongyles of ruminants in Bangladesh. Bangladesh Veterinary Journal 33(3-4), 93-97.

      [38] Sharma LK (1992) Efficacy of anthelmintics administered through capsule against natural gastro-intestinal nematodes in cattle. Indian Veterinary Journal 69, 1134-1135.

      [39] Sharma LK & Jagadish S (1991) Efficacy of Levamisole administered through different routes against gastro-intestinal nematodes in cross-breed cattle. Indian Veterinary Journal 68, 16-18.

      [40] Silverman PH, Mansfield ME & Scott HL (1970) Contortus, infection in sheep, effects of various leaves of primary infection on nopan treated lambs. American Journal of Veterinary Research 31(5), 841-857.

      [41] Sinha HK, Grisvastava PS, Singh SP, Singh VK & Singh SRP (1987) Efficacy of various anthelmintics on the mortality of the infective larvae of Toxocara vitulorum and treatment of calf ascariasis. Indian journal of animal sciences 57, 185-188.

      [42] Soulsby EJL (1982) Helminth, Arthropods and protozoa of domestic animals 7th Ed. E.L.S. 13 Pub. Tindall, Castell London. pp. 763-766.

      [43] Soulsby EJL (1986) Helminths, Arthropods and Protozoa of Domesticated Animals, 7th Ed, The ELBS and Baillier Tindall, London, UK.

      [44] Soutello RG, Seno MC & Amarante AF (2007) Anthelmintic resistance in cattle nematodes in northwestern São Paulo State, Brazil. Veterinary Parasitology 148(3-4), 360-364.

      [45] Thejomoorthy P, Sundararama MN, Napolean RE & Gajendran K (1995) Comparative efficacy of fenbendazole and Levamisole against nematodes in calves. Cheiron 24(5-6), 154-162.

      [46] Theodorides VJ, Nawalinski T, Murphy J & Freeman J (1976) Efficacy of albendazole against against-intestinal nematodes of cattle. American journal of veterinary research 37(12), 1517-1518.

      [47] Vesconcalos OT, Costa AJ, Aranties GJ, Barbosa OF & Paulillo AC (1995) Anthelmintics activity of pour on levamisole against gastro-intestinal nematodes in cattle. Revista Brasileira de Parasitologia Veterinaria 4, 95-98.

      [48] Wescott RB, Farrell CJ, Gallina AM & Foreyt WJ (1979) Efficacy of albendazole for treatment of naturally acquired nematodes infections in cattle in Washington. American journal of veterinary research 40(3), 369-371.

      [49] Willams JC & Broussand SD (1995) Comparative efficacy of Levamisole thiabendazole and fenbendazole against cattle gastro-intestinal nematodes. Veterinary Parasitology 58, 83-90. http://dx.doi.org/10.1016/0304-4017(94)00701-D.

      [50] Willams JC, Sheehan D & Fuselier RH (1977) Effect of albendazole on gastro-intestinal parasites of cattle. American journal of veterinary research 38(12), 2037-2038.

      [51] Wilson LL (1969) Effects of Haemonchus Contortus inoculation on growth rate, feed efficacy and hematology of feeder lambs. Veterinary medicine 64(1), 59-62.

      [52] Yadav L & Kumar S (1990). Trial of albendazole and nematodes against natural gastro-intestinal nematodes of Camels. Indian Veterinary Journal 67, 864.

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  • How to Cite

    Islam, M., Islam, S., Howlader, M., & Lucky, N. (2015). Comparative efficacy of Albendazole, Fenbendazole and Levamisole against gastrointestinal nematodiasis in cattle of Bangladesh. International Journal of Biological Research, 3(1), 25-35. https://doi.org/10.14419/ijbr.v3i1.4301

    Received date: 2015-02-04

    Accepted date: 2015-03-02

    Published date: 2015-03-17