Effects of oxyclozanide (Tremacid®) preparation against fascioliasis on clinical and haematological parameters in cattle of Bangladesh

  • Abstract
  • Keywords
  • References
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  • Abstract

    The effects of Oxyclozanide (Tremacid®) on some clinical (body weight) and haematological parameters (TEC, Hb, PCV, ESR and TLC) were determined in this study. Among 55 cattle, 10 were selected, which were suffering from fascioliasis and divided randomly into two groups. Each group was consisting of five cattle. One was treated with Tremacid® @ (15 mg/kg body weight). Other was kept as an infected control group. Before trials with Tremacid® initial body weight, EPG of liver fluke and hematological parameters were examined. During the experimental period the faecal samples, clinical and hematological parameters were examined on 7th, 14th, 21st and 28th days for the determination of effects of Tremacid®. A significant reduction of EPG count was found on 7th, 14th, 21st and 28th day of Tremacid® (61.87%, 71.22%, 76.98% and 84.53%) in a treated cattle group. The EPG of an untreated control group was significantly (p<0.01) increased about 3.97%, 7.64%, 11.04% and 64.89% respectively. Total TEC was increased after treatment with Tremacid® and decreased in an untreated control group significantly (p<0.01), Likewise, after treatment with Tremacid® Hb content and PCV were increased, and ESR was decreased. Total leukocyte count (TLC) was decreased and the body weight was increased after Tremacid® treatment in the group A. On the other hand, Hb content PCV and body weight was decreased significantly (p<0.01) in the group B.

  • Keywords

    Body Weight; Cattle; Fascioliasis; Haematological Parameter; Oxyclozanide.

  • References

      [1] Anonymous (1995) Poultry outlook Supplement to tailstock Dairy and Poultry situation and outlook. Economic Research Service, US, Department of Agriculture, LDP-P-S, February 28, 1995, Washington, DC.

      [2] Anonymous (1985) Asian Livestock Society. X (5), 49.

      [3] Babicek K, Sevcik B & Zavadil R (1993) Testing the efficacy of fasciolicidal agents intraperitoneally implanted Fasciola hepatica in laboratory mice. Biopharm 3(5/6), 169-178.

      [4] Baker JR & Muller R (1988) Journal of Advance in Parasitology 27, 244-250.

      [5] Bangladesh Livestock Research Institute (BLRI), 2006. Financed by SICT Program, Ministry of Planning, and Government of the People's Republic of Bangladesh.

      [6] Bangladesh Bureau of Statistics-BBS (2010) Report of the Household-based Livestock and Poultry Survey 2009.

      [7] Chowdhury MR, Huq MA, Howlader MMR, Islam MS, Akanda MR & Akhand RN (2014) Comparative efficacies of two different com­mercial products containing nitroxynil against fascioliasis in cat­tle. Eurasian Journal of Veterinary Sciences 30(2), 59-62.

      [8] Coles GC & Stafford KA (2001) Activity of oxyclozanide, nitroxynil, clorsulon and albendazole against adult triclabendazole resistant Fasciola hepatica, Veterinary Record 148, 723-724. http://dx.doi.org/10.1136/vr.148.23.723.

      [9] Cockrill WR (1974) The Husbandry and Health of Domestic Buffalo. FAO, Rome, Italy.

      [10] Diaw DT, Seye M & Sarr Y (1998) Epidemiology of trematodiases in livestock in the Kolda region, Casamance. Revue d Elevageet de Medecine Veterinaire des Pays Tropicaux (Paris) 41, 257-264.

      [11] Economic index (2010) Finance division, Ministry of Finance, Government of the People Republic of Bangladesh, www.mof.gov.bd.

      [12] Fabiyi JP (1986) Production losses and control of helminthes in ruminants of tropical regions. Parasitology 17, 435-442.

      [13] Gupta RP (1988) Efficacy of Trodax® against natural infection of Fasciola in buffaloes. Indian Veterinary Journal 65, 254-255.

      [14] Gupta SC & Singh BP (2002) Fascioliasis in cattle and buffaloes in India. Journal of Veterinary Parasitology16, 139-145.

      [15] Hiepe T, von der Ahe C, Rüffle E & Trolldenier H (1970) Treatment of bovine fascioliasis with tribromsalan, menichlopholan (niclo-folan) and oxyclozanide. Journal of Monatshefte fur Veterinarmedizin 25, 306-310.

      [16] Islam MA & Samad MA (1989) Efficacy of commercial fasciolicides against mixed infection of fascioliasis and amphistomiasis and cattle. Bangladesh Veterinarian 6, 27-32.

      [17] Isles DH, Davison M & Frost RJ (1985). Influences of frequency of anthelmintic treatment on the growth rate of Australian Friesian sahiwal heifers. Australian Veterinary Journal 62, 189-191. http://dx.doi.org/10.1111/j.1751-0813.1985.tb07293.x.

      [18] Kabir MHB, Eliyas M, Hashem MA, Mohiuddin & Miazi OF (2010) Prevalence of zoonotic parasitic diseases of domestic animals in different abattoir of Comilla and Brahman Baria region in Bangladesh.Univer. University Journal of Zoology 28, 21-25.

      [19] Kamruzzaman M (2004) Comparative efficacy of triclabendazole, nitroxynil & Oxyclozanide preparation against fascioliasis in cattle. 79-88.

      [20] Kamaruddin KM (2003) Goat farming as a means of poverty alleviation. In: Proceedings of BSVER symposium. Goats farming in Bangladesh; Problems and prospects. BAU. Bangladesh Society for Veterinary Education & Research. BSVER Publications 25, 26-34.

      [21] Mason CS & Offer JE (2004) Fascioliasis associated with metabolic disease in dairy herd and its effects on health and productivity. Cattle Practice12, 7-13.

      [22] McConville M, Brennan GP, McCoy m, Hernandez-Campos a, Ibarra f & Fairweather i (2006). Adult triclabendazole-resistant Fasciola hepatica: surface and subsurface tegumental responses to in vitro treatment with the sulphoxide metabolite of the experimental fasciolicide compound alpha. Parasitology 133(2), 195-208. http://dx.doi.org/10.1017/S0031182006000114.

      [23] Mooney L, Good B, Hanrahan JP, Mulcahy G & de Waal T (2009) The comparative efficacy of four anthelmintics against a natural acquired Fasciola hepatica infection in hill sheep flock in the west of Ireland.Veterinary Parasitology 164(2-4), 201-205. http://dx.doi.org/10.1016/j.vetpar.2009.05.017.

      [24] Nwosu CO, Eneme TA, Onyeyili PA, Ogugbuaja VO (2007) Toxicity and anthelmintic efficacy of crude aqueous of extract of the bark of Sacoglottisgabonensis.Fitoterapia, 79(2), 101-5.

      [25] Okaiyeto SO, Salami OS, Dnbirni SA, Allam L & Onoja II (2012) Clinical, Gross and Histopathological Changes Associated with Chronic Fascioliasis Infection in a Dairy Farm. Journal of Veterinary Advance 2(8), 444-448.

      [26] Ozung PO, Owa PU & Oni KO (2011) An Assessment of the Prevalence of Fascioliasis of Ruminants in Ikom Abattoir of Cross River State, Nigeria. Continental Journal of Veterinary Science 5 (1), 1-5.

      [27] Okoli IC (2001) Analysis of abattoir records for Imo State, Nigeria, 1995-1999: I: Disease incidence in cattle, sheep and goats. International Journal of Agriculture and Rural Development 2, 97-103.

      [28] Paraud C, Gaudin C, Pors I & Chartier C (2009) Efficacy of oxy­clozanide against the rumen fluke Calicophorondaubneyi in experimentally infected goats. Veterinary Journal 180 (2), 265-7. http://dx.doi.org/10.1016/j.tvjl.2008.01.002.

      [29] Prasad KD & Bharti P (2001) Assessment of oxyclozanide efficacy against chronic natural fascioliasis or paramphistomiasis in cattle and buffaloes. Journal of Research of Birsa Agricultural University 13(2), 245-248.

      [30] Phiri AM, Phiri IK, Chotaa & Monrad J (2007) Trematode infections in freshwater snails and cattle from the Kafue wetlands of Zambia during a period of highest cattle–water contact. Journal of Helminthology 81, 85–92.http://dx.doi.org/10.1017/S0022149X07387786.

      [31] Qadir ANMA (1981). A preliminary study on the epidemiology of Fascioliasis in goats. Bangladesh Veterinary Journal15, 13-17.

      [32] Queiroz GR, Filho LFCC, Zanluchi AT, Junior FABM & Okano W (2013) Effect of dilatation of the cerebral ventricles after the administration of nitroxynil in swiss albine mice du­ring organogenesis. Archives of Veterinary Science 18(1), 23-28.

      [33] Rahman A, Ali KM & Rahman A (1972) Incidence of diseases of cattle in Mymensingh. Bangladesh Veterinary Journal 6, 25-30.

      [34] Rahman MH & Razzak A (1973) Incidence of helminth parasites infecting cattle in the Kotwali thana of Comilla. First Bangladesh Veterinary Conference, Bangladesh Agricultural University, Mymensingh, Bangladesh.

      [35] Rapic D, Dzakula N, Sakar D & Richards RJ (1988) Comparative efficacy of triclabendazole, nitroxynil and rafoxanide against immature and mature Fasciola hepatica in naturally infected cattle in Yugoslavia. Veterinary Record 122(3), 59-62. http://dx.doi.org/10.1136/vr.122.3.59.

      [36] Ratnaparkhi MR, Shastri SR & Jamkhedkar PP (1993) Efficacy of Disodia® (pfizer) against fascioliasis in cattle, buffaloes and goats under field condition. Indian Veterinary Journal 70(2), 157-159.

      [37] Ratnaparkhi MR, Shastri UV, Narladkar BW, Digraskar SU &Degloorkar NM (1992) A note on efficacy of some flukicides against Fasciola infection in domestic animals. Indian Journal of Veterinary Medicine 12(1), 20.

      [38] Richards RJ, Bowen FL, Essenwein F, Steiger RF & Buscher G (1990) The efficacy of triclabendazole and other anthelmintics against Fasciola hepatica in controlled studies in cattle. Veterinary Record126 (9), 213-216.

      [39] Rodistis OM, Gay CC, Blood DC & Hincheliff KW (2000) Veterinary Medicine.9th end. Harcourt Publishers Ltd. London. pp. 1339-1342.

      [40] Roy RM & Sukhla SS (1971) Oxyclozanide-Activity against fasciola gigantica in naturally infected buffalo, cattle, sheep and goats. Journal of Tropical Animal Health and Production 3(1), 26-31

      [41] Sahoo N, Mohanty TN, Patra BK, Mallick HN & Samal S (2002) Efficacy of oxyclosanide, closantel and triclabendazole against Fasciola infeciton in cattle a field trial in rainfed area of Orissa. Indian Veterinary Journal 79(8), 774-775.

      [42] Saiful M, Mostofa M, Rafiq K & Lucky NS (2003) Comparative efficacy of Albendazole and Ivermectin against gastrointestinal nematodiasis in Goats. Bangladesh Journal of Animal Science 32(1-2), 121-130.

      [43] Samad MA (1996) Poshupalon o chikissavidya (In Bengali), 1st edition, LE Publications, Dhaka, Bangladesh.

      [44] Sanchez AE, Ibarra VF, Perez TJ & Casas CE (1988) Evaluation of weight gain in sheep infected experimentally with Fasciola hepatica and treated with triclabendazole. Veterinaria Mexico journal 19(2), 145-149.

      [45] Schwabe CW (1984) Veterinary Medicine and Human Health, 3rd edn, Williams and Wilkins, Baltimore, pp. 472-85.

      [46] Shahiduzzaman AKM, Talukder MH & Rahman MH (1999) Ecology of reparasitic stages of Strongyles of ruminants in Bangladesh. Bangladesh Veterinary Journal 33(3-4), 93-97.

      [47] Soulsby EJL (1986) Helminth, Arthropod and Protozoa of Domesticated Animals. 7th edn, Bailliere and Tindall, PA, London, pp. 763-766.

      [48] Talukder S, Bhuiyan MJ, Hossain MM, Uddin MM, Paul S & Howlader MMR (2010) Pathological Investigation of Liver Fluke Infection of Slaughtered Black Bengal Goat in a selected Area of Bangladesh. Bangladesh Journal of Veterinary Medicine 8 (1), 35 – 40.

      [49] Valero MA, Santana M, Morales M, Hernandez JL & Santiago M (2003) Risk of Gallstone Disease in Advanced Chronic Phase of Fascioliasis. An Experimental Study in a Rat model. Journal of Infectious Diseases 188, 787 – 793. http://dx.doi.org/10.1086/377281.

      [50] Waruiru RM, Weda EH & Munyua WK (1994) the efficacy of triclabendzole and oxyclozanide against Fasciola gignatica in naturally infected dairy cattle in Kenya. Animal Health and Production in Africa 42(3), 205-209.

      [51] Widjajanti S, Estuningshih SE & Suharyanta (2001). Antibody response of cattle infected with Fasciola gigntica and the effect of triclabendazole treatment. J IIum Tern dan Vet, 6(4), 266-269.

      [52] World Health Organization (2006) Animal Production and Health Paper no. 78 United States of America.




Article ID: 4486
DOI: 10.14419/ijbr.v3i1.4486

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