Assessment and comparison of the levels of N-nitrosonornicotine and 4-(n-methyl-n –nitrosamino) -1-(3-pyridyl)-1-butanone in the saliva of tobacco chewers and non- chewers -a hospital based study

 
 
 
  • Abstract
  • Keywords
  • References
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  • Abstract


    Background: Studies estimating the Tobacco- specific nitrosamines, (TSNA’s) which are the strongest carcinogens in the saliva of

    tobacco users and tobacco quitters, are limited.

    Objectives: To assess and compare the levels of N- nitrosamines (NNN, NNK) in the saliva of tobacco chewers and non -chewers

     including those who have quit the habit of tobacco use.

    Methods: The study included 120 patients who were divided into three groups of 40 each: Group I- Smokeless tobacco chewers

    Group II- Tobacco chewers who have completely stopped the habit at least 2 weeks prior to sample collection and

    Group III- non-chewers. The salivary levels of two tobacco specific nitrosamines; NNN & NNK levels were estimated in the three study groups. Statistical analysis was done by Kruskal– Wallis, one-way analysis of variance (ANOVA) test, Mann-Whitney U test. (p-value < 0.05 was considered to be statistically significant)

    Results: In Group I, the mean level of NNN was 651.84 ± 359.78 and mean level of NNK was 168.32 ± 131.83. In Group II, the mean level of NNN was 119.52 ± 95.05 and mean level of NNK was 42.78 ± 43.19. In Group III, the mean level of NNN was 3.44 ±6.55 and mean level of NNK was 1.98 ± 3.68. There was a statistical difference in the 3 groups with respect to mean levels of NNN and NNK.

    Conclusion: The study indicated that salivary tobacco-specific nitrosamines are elevated in tobacco chewers. Saliva can be used to detect TSNA’s and screen for TSNA’s during each patient’s de-addiction process.

     

     


  • Keywords


    NNK; NNN; Saliva; Smokeless Tobacco; Tobacco-Specific Nitrosamines (TSNA’s).

  • References


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Article ID: 11943
 
DOI: 10.14419/ijdr.v6i2.11943




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