The effectiveness of platelet concentrations in periodontal surgeries

 
 
 
  • Abstract
  • Keywords
  • References
  • PDF
  • Abstract


    Platelets release several growth factors which stimulate tissue regeneration. Several techniques for platelet concentrates such as platelet rich plasma (PRP), plasma rich in growth factors (PRGF), platelet rich fibrin (PRF) and concentrated growth factors (CGF) have been introduced in dental surgeries for the prevention of hemorrhage and acceleration of tissue regeneration. However, a fabricating growth factors-enriched bone graft matrix which is called “sticky bone” has been demonstrated to provide stabilization in bony defects. In this article, we presented the method of preparing and utilizing CGF and sticky bone and evaluate the effect of CGF mixed with bone graft and CGF barrier membrane in periodontal surgeries.

    Methodology: We used websites such as PubMed, Scopus, and ISI Web of knowledge to get related articles about this subject. The research process involved specific key words " concentrated growth factor”- “Platelet rich fibrin”- growth factors-enriched bone graft” - “sticky bone” to find more articles which published from 2007 to March 2018.

    Results: We reviewed 48 articles, 43 articles were excluded. Only five articles have been conducted. Original human studies and case report were included.

    Conclusion: We concluded that the use of sticky bone and CGF is effective in bone grafting and implant.

     

     


  • Keywords


    Concentrated Growth Factors; Platelet Rich Fibrin; Ridge Augmentation; Growth Factors-Enriched Bone Graft; Sticky Bone. Guided Bone Regeneration

  • References


      [1] Sohn DS..Utilization of Autologous Concentrated Growth Factors (CGF) Enriched Bone Graft Matrix (Sticky Bone) and CGF-Enriched Fibrin Membrane in Implant Dentistry. The Journal of Implant & Advanced Clinical Dentistry.2015; 7:10:11-29.

      [2] Kshirsagar JT, Innovation in regeneration – Concentrated growth factor, International Journal of Applied Dental Sciences 2017; 3(2): 206-208.

      [3] Kingsley CS. Blood coagulation; evidence of an antagonist to factor VI in platelet-rich human plasma. Nature. 1954; 173:723–724. https://doi.org/10.1038/173723a0.

      [4] Matras H. [Effect of various fibrin preparations on reimplantations in the rat skin] Osterr Z Stomatol. 1970; 67:338–359.

      [5] Choukroun J, Adda F, Schoeffer C, Vervelle A. PRF: An opportunity in perio implantology. Implantodontie. 2000; 42:55–62.

      [6] Bernardi S, Mummolo S, Tecco S, Continenza MA & Marzo G. Histological characterization of Sacco has concentrated growth factors membrane. Int. J. Morphol.2017, 35(1):114-119. https://doi.org/10.4067/S0717-95022017000100019.

      [7] Aghaloo TL, Moy PK. Which hard tissue augmentation techniques are the most successful in furnishing bony support for implant placement? Int J Oral Maxillofac Implants.2007; 22:49-70.

      [8] Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF) Trends Biotechnol 2009 27:158–167. https://doi.org/10.1016/j.tibtech.2008.11.009.

      [9] Sohn DS, Moon JW, Moon YS, Park JS, Jung HS. The use of concentrated growth factors (CGF) for sinus augmentation. J Oral Implant. 2009; 38:25–38.

      [10] Mishra A, Harmon K, Woodall J, Vieira A. Sports medicine applications of platelet rich plasma. Curr Pharm Biotechnol. 2012; 13:1185–1195. https://doi.org/10.2174/138920112800624283.

      [11] DeLong JM, Russell RP, Mazzocca AD. Platelet-rich plasma: the PAW classification system. Arthroscopy. 2012; 28:998–1009. https://doi.org/10.1016/j.arthro.2012.04.148.

      [12] Tunalı M, Özdemir H, Küçükodacı Z, Akman S, Fıratlı E. In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): a new platelet concentrate. Br J Oral Maxillofac Surg. 2013; 51:438–443. https://doi.org/10.1016/j.bjoms.2012.08.003.

      [13] Mourão CF, Valiense H, Melo ER, Mourão NB, Maia MD. Obtention of injectable platelets rich-fibrin (i-PRF) and its polymerization with bone graft: technical note. Rev Col Bras Cir. 2015; 42:421–423. https://doi.org/10.1590/0100-69912015006013.

      [14] Anitua E, Tejero R, Zalduendo MM, Orive G. Plasma rich in growth factors promotes bone tissue regeneration by stimulating proliferation, migration, and autocrine secretion in primary human osteoblasts. J Periodontol. 2013; 84:1180–1190. https://doi.org/10.1902/jop.2012.120292.

      [15] Rosenkranz S, Kazlauskas A. Evidence for distinct signaling properties and biological responses induced by the PDGF receptor alpha and beta subtypes. Growth Factors. 1999 16(3):201-216. https://doi.org/10.3109/08977199909002130.

      [16] Anitua E, Alonso R, Girbau C, Aguirre JJ, Muruzabal F, Orive G. Antibacterial effect of plasma rich in growth factors (PRGF ®-Endoret®) against Staphylococcus aureus and Staphylococcus epidermidis strains. Clin Exp Dermatol.2012 Aug 37(6):652-7. https://doi.org/10.1111/j.1365-2230.2011.04303.x.

      [17] Rodella LF, Favero G, Boninsegna R, et al. Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction. Microsc Res Tech. 2011 74 (8):772-777. https://doi.org/10.1002/jemt.20968.

      [18] Plachokova AS, Nikolidakis D, Mulder J, Jansen JA, Creugers NH. Effect of platelet-rich plasma on bone regeneration in dentistry: a systematic review. Clincal Oral Implants Res. 2008 19 (6):539-45. https://doi.org/10.1111/j.1600-0501.2008.01525.x.

      [19] Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, and Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85 (6):638-46 https://doi.org/10.1016/S1079-2104(98)90029-4.

      [20] Upadhayaya V, Arora A, Goyal A. Bioactive Platelet Aggregates: Prp, Prgf, Prf, Cgf And Sticky Bone .JDMS 2017;16(5):5-11

      [21] Kim JY , Rehabilitation of A Non-Restorable Maxillary Central Incisor Tooth for Function and Esthetic Utilizing An Immediate Placement and Provisionalization Protocol, Global Dental Implant Academy.2016;1(1):1-4.

      [22] Sohn DS. Lecture titled with sinus and ridge augmentation with CGF and AFG, Symposium on CGF and AFG. Tokyo, June 6; 2010.

      [23] Bozkurt Dog an S, O€ngo€z Dede F, Ballı U, Atalay EN, Durmu slar MC. Concentrated growth factor in the treatment of adjacent multiple gingival recessions: a split mouth randomized clinical trial. J Clin Periodontol. 2015; 42:868-875. https://doi.org/10.1111/jcpe.12444.

      [24] Wang HL1, Al-Shammari K. HVC ridge deficiency classification: a therapeutically oriented classification. Int J Periodontics Restorative Dent. 2002 22 (4):335-343.

      [25] Sohn DS, Heo JU, Kwak DH et al. Bone regeneration in the maxillary sinus using an autologous fibrin-rich block with concentrated growth factors alone. Implant Dent.2011; 20(5):389-395. https://doi.org/10.1097/ID.0b013e31822f7a70.

      [26] Gupta V., Bains B.K., Singh G.P., Mathur A., Bains R. Regenerative potential of platelet rich fibrin in dentistry: literature review. Asian. J. Oral. Health. Allied. Sci. 2011; 1:22–28.

      [27] Ayoub AH, Ramadan OR, Agbor MA. Tissue Engineering, Platelets Concentrates and it’s Role in Dental Implant Treatment. EC Dental Science 2016; 5(1):969-980.

      [28] Qiao J, Duan J, Zhang Y, Chu Y, Sun C. The effect of concentrated growth factors in the treatment of periodontal intrabony defects. Future Science OA.2016 2 (4):FS136.


 

View

Download

Article ID: 12414
 
DOI: 10.14419/ijdr.v6i2.12414




Copyright © 2012-2015 Science Publishing Corporation Inc. All rights reserved.