Peripheral giant cell granuloma: a case repo

  • Authors

    • Saad Shahnawaz Ahmed Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad
    • Hira Zaman Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad
    • Fahad Bin Abrar Islamabad Medical and Dental College
    • Sadia Khalid Shifa International Hospital
  • Anesthesia, Excisional Biopsy, Giant Cell, Granuloma, Lesion
  • Peripheral giant cell granuloma (PGCG) is a common benign gingival lesion in the oral cavity of unknown origin, believed to be stimulated by local irritation or chronic trauma. It is also known as giant cell epulis, giant cell reparative granuloma, or giant-cell hyperplasia, presenting as purplish-red soft tissue nodule clinically and histologically consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells. This case report describes a 40 year old male previously reported with peripheral giant cell granuloma 2 years back which on excision reoccurred after 3-4 months and persistently growing since then. The gingival lesion between his maxillary central incisors was excised and the Biopsy specimen sent in 10% formalin to histopathological lab and was diagnosed as PGCG. There was good healing of tissue of the surgical site during the 9 months follow-up.

  • References

    1. [1] Pour MAH, Rad M, Mojtahedi A. A Survey of Soft tissue Tumor-Like Lesions of Oral Cavity: A Clinicopathological Study. Iran J Pathol. 2008; 3: 81-7.

      [2] Neville B.W., Damm D.D., Allen C.M. and Bouquot J.E.Oral and Maxillofacial Pathology, Pennysylvania: W B Saunders Company, 2004; 449-50.

      [3] Aslan M, Kaya GS, Day E, Demirci E. A Peripheral giant cell granuloma in early age (case report). Ataturk Univ Dis Hek Fak Derg 2006; 16(3):61-4.

      [4] Etoz OA, Demirbas AE, Bulbul M, Akay E. The peripheral giant cell granuloma in edentulous patients. Report of three unique cases. Eur J Dent. 2010; 4:329–33.

      [5] D. G. Olmedo, M. L. Paparella, D. Brandizzi, and R. L.Cabrini. Reactive lesions of peri-implant mucosa associated with titanium dental implants: a report of 2 cases.Int J Oral Maxillofac Surg.2010; 39(5): 503–7.

      [6] I. Dojcinovic, M. Richter, and T. Lombardi. Occurrence of a pyogenic granuloma in relation to a dental implant. J. Oral Maxillofac. Surg. 2010; 68 (8):1874–6.

      [7] Ga’ndara JM, Pacheco JL, Ga’ndara P, et al. Granuloma perife’rico de ce’lulas gigantes. Revisio’n de 13 casos clı’nicos. Med Oral Med Oral Patol Oral Cir Bucal. 2002; 7:254–9.

      [8] Motamedi, M.H.K., Eshghyar, N., Jafari, S.M., Lassemi, E., Navi, F., et al. (2007) Peripheral and Central Giant Cell Granulomas of the Jaws: A Demographic Study. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 103, e39-e43.

      [9] Pogrel AM. The diagnosis and management of giant cell lesions of the jaws. Ann Maxillofac Surg 2012; 2:102-6.

      [10] Gandara RJM, Carneiro PM, Gandara VP, Carrion BA, Garcia GA, Grana P, Martin. Peripheral giant cell granuloma. Review of 13 cases. Med Oral. 2002; 7(4): 254-59.

      [11] Muratakgül H., Güngrmü M., and Harorli A. Peripheral giant cell granuloma: A clinical and radiological study.Fundamentals of Radiology and Radiodiagnostics in Dentistry, 2004; 16: 59-63

      [12] Kumar A, Singh VP and Shah P. Peripheral Giant Cell Granuloma: a Case Report. J Dent App. 2014; 1 (3): 43-5.

      [13] Ragezi JA, Sciubba JJ, Jordan RC. Oral pathology: Clinico-pathological considerations. 4th ed. Philadelphia: W B Saunders. 2003:115-6.

      [14] Pen˜ arrocha-Diago.M , Cervera-Ballester.j , Maestre-Ferrı´n.L , Pen˜ arrocha-Oltra.D. Peripheral Giant Cell Granuloma Associated With Dental Implants: Clinical Case and Literature Review.journal or oral implantology. 2012;38:(1):527-32

      [15] Pirih, F., Barroso, A.D., Tatarakis, N., Cordell, K., McCauley, L. and Edwards, P. A Case Report of a Peripheral Giant Cell Granuloma in a Patient on Forteo. Open Journal of Stomatology. 2015; 5, 147-51

      [16] Fraser, W.D. (2009) Hyperparathyroidism. The Lancet, 374, 145-58.

      [17] Grand E, Burgener E, Samson J, Lombardi T. Post-traumatic development of a peripheral giant cell granuloma in a child. Dent Traumatol. 2008; 24:124–6.

      [18] Mannem S, Chava VK. Management of an unusual peripheral giant cell granuloma: A diagnostic dilemma. Contemp Clin Dent. 2012; 3:93-6

      [19] Shadman N, Ebrahimi SF, Jafari S, Eslami M. Peripheral giant cell granuloma: A review of 123 cases. Dent Res J (Isfahan) .2009;6:47–50

      [20] Chaparro-Avendano AV, Berini-Aytes L, Gay-Escoda C. Peripheral giant cell granuloma. A report of five cases and review of the literature. Med Oral Patol Oral Cir Bucal. 2005; 10 (1):53–7. [PubMed].

  • Downloads

  • How to Cite

    Ahmed, S. S., Zaman, H., Bin Abrar, F., & Khalid, S. (2016). Peripheral giant cell granuloma: a case repo. International Journal of Dental Research, 4(2), 44-46.