Green tea in medicine: a brief overview

 
 
 
  • Abstract
  • Keywords
  • References
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  • Abstract


    Over the past decades, focused interest in drugs obtained from medicinal plants has markedly increased. Since times immemorial, tea has traditionally been the most popular and widely consumed beverages in the world obtained from the extracts of leaves of the plant Camellia sinensis by the process of oxidation. It is the oldest non-alcoholic beverage containing caffeine. Among the varieties of tea manufactured, green tea is considered of utmost significance since it exerts antimicrobial, anti-cancer, antioxidant, anti-collagenase, anti-diabetic, anti-obesity and anti-hypertensive activities due to rich content of polyphenol, namely catechins, which prevent the pathogenesis of numerous disease processes and play a pivotal role as a scavenger of free radical generation. The present review discusses the botanical description, photo-chemical constituents and biological activity of green tea with clinical relevance in the various fields of medicine.


  • Keywords


    Green Tea; Camellia Sinensis; Antimicrobial; Anti-Cancer; Antioxidant; Anti-Collagenase; Anti-Diabetic; Anti-Obesity; Anti-Hypertensive; Polyphenol; Photo-Chemicals

  • References


      [1] Mahmood T, Akhtar N, Khan BA (2010). The morphology, characteristics and medicinal properties of Camellia sinensis tea. J Med Plants Res 4, 2028-33. https://doi.org/10.5897/JMPR10.010.

      [2] Cabrera C, Artacho R, Gimenez R (2006). Beneficial effects of green tea: A review. J Am Coll Nutr 25, 79-99. https://doi.org/10.1080/07315724.2006.10719518.

      [3] Narotzki B, Reznick AZ, Aizenbud D, Levy Y (2012). Green tea: A promising natural product in oral health. Arch Oral Biol 57, 429-35. https://doi.org/10.1016/j.archoralbio.2011.11.017.

      [4] Chacko SM, Thambi PT, Kuttan R, Nishigaki I (2010). Beneficial effects of green tea: A literature review. Chinese Med 5, 1-9. https://doi.org/10.1186/1749-8546-5-13.

      [5] Chan EWC, Soh EY, Tie PP, Law YP (2011). Antioxidant and antibacterial properties of green, black and herbal teas of Camellia sinensis. Pharmacognosy Res 3, 266-72. https://doi.org/10.4103/0974-8490.89748.

      [6] Katiyar SK, Raman C (2011). Green tea: A new option for the prevention or, control of osteoarthritis. Arthritis Res Ther 13, 121. https://doi.org/10.1186/ar3428.

      [7] Watanabe J, Kawabata J, Niki R (1998). Isolation and identification of acetyl-CoA carboxylase inhibitors from green tea (Camellia sinensis). Biosci Biotechnol Biochem 62, 532-4. https://doi.org/10.1271/bbb.62.532.

      [8] Sabu MC, Smitha K, Kuttan R (2002). Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes. J Ethnopharmacol 83, 109-16. https://doi.org/10.1016/S0378-8741(02)00217-9.

      [9] Yokogoshi H, Kato Y, Sagesaka YM, Matsuura T (1995). Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci Biotechnol Biochem 59, 615-8. https://doi.org/10.1271/bbb.59.615.

      [10] Hegarty VM May HM, Khaw KT (2000). Tea drinking and bone mineral density in older women. Am J Clin Nutr 71, 1003-7.

      [11] El-Beshbishy HA (2005). Hepato-protective effect of green tea (Camellia sinensis) extract against tamoxifen-induced liver injury in rats. J Biochem Mol Biol 38, 563-70.

      [12] Kuo CL, Chen TS, Liou SY, Hsieh CC (2014). Immuno-modulatory effects of EGCG fraction of green tea extract in innate and adaptive immunity via T regulatory cells in murine model. Immuno-pharmacol Immuno-toxicol 36, 364-70. https://doi.org/10.3109/08923973.2014.953637.

      [13] Kakuda T (2002). Neuro-protective effects of the green tea components theanine and catechins. Biol Pharm Bull 25, 1513-8. https://doi.org/10.1248/bpb.25.1513.

      [14] Heo JC, Kim SH, Kim TH, Lee SH (2007). An aqueous extract of green tea Camellia sinensis increases expression of TH1 cell specific anti-asthmatic markers. Int J Mol Med 22, 763-7.

      [15] Elmets CA, Singh D, Tubesing K, Matsui M, Katiyar S, Mukhtar H (2001). Cutaneous photo-protection from ultraviolet injury by green tea polyphenols. J Am Acad Dermatol 44, 425-32. https://doi.org/10.1067/mjd.2001.112919.

      [16] Hirano R, Momiyama Y, Takahashi R, Taniguchi H, Kondo K, Nakamura H, et al (2002). Comparison of green tea intake in Japanese patients with and without angiographic coronary artery disease. Am J Cardiol 90, 1150-3. https://doi.org/10.1016/S0002-9149(02)02787-X.

      [17] Horiba N, Maekawa Y, Ito M, Matsumoto T, Nakamura H (1991). A pilot study of Japanese green tea as a medicament with antibacterial and bactericidal effects. J Endod 17, 122-4. https://doi.org/10.1016/S0099-2399(06)81743-7.

      [18] Kumar B, Gupta SK, Nag TC, Srivastava S, Saxena R (2012). Green tea prevents hyperglycemia-induced retinal oxidative stress and inflammation in streptozotocin-induced diabetic rats. Opthalmic Res 47, 103-8. https://doi.org/10.1159/000330051.

      [19] Suganuma M, Saha A, Fujiki H (2011). New cancer treatment strategy using combination of green tea catechins and anti-cancer drugs. J Japanese Cancer Assoc 102, 317-23. https://doi.org/10.1111/j.1349-7006.2010.01805.x.

      [20] Alappat B, Jaclyn A, Truong SC (2015). Anti-cancer and Antioxidant Properties of Flavoured Green Tea Extracts. J of Agriculture and Life Sciences 2, 15-24.

      [21] Ullah N, Ahmad M, Aslam H, Tahir MA, Aftab M, Bibi N, et al (2016). Green tea phyto-compounds as anti-cancer: A review. Asian Pac J Trop Dis 6, 330-6. https://doi.org/10.1016/S2222-1808(15)61040-4.

      [22] Khan N, Afaq F, Saleem M, Ahmad N, Mukhtar H (2006). Targeting Multiple Signalling Pathways by Green Tea Polyphenol-Epigallo-catechin-3-Gallate. Cancer Res 66, 2500-5. https://doi.org/10.1158/0008-5472.CAN-05-3636.

      [23] Call TG, Shanafelt TD (2009). Phase I trial of daily oral polyphenol in patients with asymptomatic stage of chronic lymphocytic leukemia. J Clin Oncol 27, 3808-14. https://doi.org/10.1200/JCO.2008.21.1284.

      [24] Suyama E, Tamura T, Ozawa T, Suzuki A, Iijima Y, Saito T (2011). Re-mineralization and acid resistance of enamel lesions after chewing gum containing fluoride extracted from green tea. Aust Dent J 56, 394-400. https://doi.org/10.1111/j.1834-7819.2011.01359.x.

      [25] Chaterjee P, Chandra S, Dey P, Bhattacharya S (2012). Evaluation of anti-inflammatory effects of green tea and black tea: A comparative in-vitro study. J Adv Pharm Technol Res 3, 136-8. https://doi.org/10.4103/2231-4040.97298.

      [26] Sakanaka S, Okada Y (2004). Inhibitory effects of green tea polyphenols on the production of a virulence factor of the periodontal disease causing anaerobic bacterium Porphyromonas gingivalis. J Agric Food Chem 52, 1688-92. https://doi.org/10.1021/jf0302815.

      [27] Lee YL, Hong CY, Kok SH, Hou KL, Lin YT, Chen MH (2009). An extract of green tea, Epigallocatechin-3-gallate reduces peri-apical lesions by inhibiting cysteine-rich 61 expression in osteoblasts. J Endod 35, 206-11. https://doi.org/10.1016/j.joen.2008.11.015.

      [28] Yun JH, Pang EK, Kim CS, Yoo YJ, Cho KS, Chai JK (2004). Inhibitory effects of green tea polyphenol epigallo-catechin-gallate on the expression of matrix metalloproteinase-9 on the formation of osteoclasts. J Periodont Res 39, 300-7. https://doi.org/10.1111/j.1600-0765.2004.00743.x.

      [29] Grover HS, Deswal H, Bharadwaj A (2015). Green tea as an alternative therapy in medicine and dentistry: A review. Int Ayurved Med J 3, 516-23.

      [30] Awadalla HI, Ragab MH, Bassuoni MW, Fayed MT (2011). A pilot study of the role of green tea use on oral health. Int J Dent Hyg 9, 110-6. https://doi.org/10.1111/j.1601-5037.2009.00440.x.

      [31] Nugala B, Namasi A, Emmadi P, Krishna PM (2012). Role of green tea as an antioxidant in periodontal disease: The Asian paradox. J Indian Soc Periodontol 16, 313-6. https://doi.org/10.4103/0972-124X.100902.


 

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Article ID: 7752
 
DOI: 10.14419/ijdr.v5i2.7752




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