Role of bone morphogenetic proteins in periodontal regeneration- a review
-
2016-08-27 
https://doi.org/10.14419/ijh.v4i2.6374
-
Bone Morphogenetic Proteins, Regeneration, Transforming Growth Factor-Î’ (TGF-Î’), Therapeutic Proteins, Tissue Engineering. -
Bone Morphogenetic Proteins (BMPs) are multifunctional growth factors and have the unique property of inducing stem and mesenchymal cell differentiation in to osteogenic cells, capable of producing bone. They are categorized under the super family Transforming Growth Factor-β (TGF-β). In the concept of tissue engineering they are the first approved therapeutic proteins to be used in conjunction with a scaffold and a biocompatible fixative device. Thus in this review the mechanism of action of BMPs is described at its cellular and molecular levels along with its potential clinical applications, utilization perspectives and scientific evidence in periodontal regeneration.
-
References
[1] Lin NH, Gronthos S&Bartold PM. (2009) Stem cells and future periodontal regeneration. Periodontology 2000. 51, 239–251.http://dx.doi.org/10.1111/j.1600-0757.2009.00303.x.
[2] Huang YH, Polimeni G, Qahash&M, Wikesjo UM. (2008) Bone morphogenetic proteins and osseointegration: current knowledge – future possibilities. Periodontology 2000. 47, 206-223.http://dx.doi.org/10.1111/j.1600-0757.2007.00240.x.
[3] Hallman M, Thor A. (2008) Bone substitutes and growth factors as an alternative ℠complement to autogenous bone for grafting in implant dentistry. Periodontology 2000. 47, 172–192.http://dx.doi.org/10.1111/j.1600-0757.2008.00251.x.
[4] Selvig KA, Sorensen RG, Wozney JM&Wikesjo UM.(2002) Bone repair following recombinant human bone morphogenetic protein-2 stimulated periodontal regeneration. Journal of Periodontology 73, (9):1020-1029.http://dx.doi.org/10.1902/jop.2002.73.9.1020.
[5] Granjeiro JM, Oliveira RC, Bustos-Valenzuela JC, Sogayar MC& Taga R. (2005)Bone morphogenetic proteins: from structure to clinical use.Brazilian Journal of Medical and Biological Research 38, (10):1463-73. http://dx.doi.org/10.1590/S0100-879X2005001000003.
[6] Sakou T. (1998) Bone Morphogenetic Proteins: From Basic Studies to Clinical ApproachesBone; 22(6), 591-603.
[7] Lee MB. (1997) Bone morphogenetic proteins: background and implications for oral reconstruction. A review.Journal of ClinicalPeriodontology24, (6):355–365.http://dx.doi.org/10.1111/j.1600-051X.1997.tb00198.x.
[8] Sakou T. (1998) Bone Morphogenetic Proteins: From Basic Studies to Clinical ApproachesBone; 22(6), 591-603.
[9] Subach S. (1997) Bone Morphogenetic Proteins. Journal of Dental Research 12,123-126.
[10] Lynch SE, Genco RJ, Marx RE.(1996). Tissue engineering, Applications in Maxillofacial Surgery and Periodontics. Quintessence publishing, p. 25-75.
[11] Setti S. Rengachary, M.D. (2002) Bone Morphogenetic Proteins: Basic Concepts.Neurosurgical Focus 13(6), 1-6.http://dx.doi.org/10.3171/foc.2002.13.6.3.
[12] Wozney JM. (1995) the potential role of bone morphogenetic proteins in periodontal reconstruction. Journal of Periodontology 66(6), 506-510. http://dx.doi.org/10.1902/jop.1995.66.6.506.
[13] Wozney JM. (1989) Bone morphogenetic proteins. Progress in growth factor research 1, 267-280.http://dx.doi.org/10.1016/0955-2235(89)90015-X.
[14] Termaat MF, Den Boer FC, Bakker FC, Patka P, Haarman H(2005) Bone morphogenetic proteins development and clinical efficacy in the treatment of fractures and bone defects. Journal of Bone & Joint Surgery.87(6):1367-1378http://dx.doi.org/10.2106/JBJS.D.02585.
[15] Toyono T, Nakashima M, Kuhara S, Akamine A. (1997)Expression of TGF- Superfamily Receptors in Dental Pulp. Journal of Dental Research.76(9):1555-1560http://dx.doi.org/10.1177/00220345970760090701.
[16] Vukicevic S, Sampath T (2008) Bone Morphogenetic Proteins: From local to systemic therapeutics. Birkhauser: Switzerland, p 1-6.http://dx.doi.org/10.1007/978-3-7643-8552-1.
[17] Bartold PM, Xiao Y, Lyngstaadas SP, Paine ML, Snead ML.(2006) Principles and applications of cell delivery systems for periodontal regeneration. Periodontology 2000, 41: 123–135.http://dx.doi.org/10.1111/j.1600-0757.2006.00156.x.
[18] Miyaji H, Sugaya T, Miyamoto T, Kato K, Kato H. (2002) Hard tissue formation on dentin surfaces applied with recombinant human bone morphogenetic protein-2 in the connective tissue of the palate. Journal of Periodontal Research, 37(3):204–209.http://dx.doi.org/10.1034/j.1600-0765.2002.01611.x.
[19] Lieberman JR, Daluiski A, Einhorn TA. (2002) the role of growth factors in the repair of Bone. Biology and clinical applications. Journal of Bone& Joint Surgery, 84-A(6):1032-1044.
[20] Drs. Sharon R. Bannister, Chair and Douglas R. Dixon, Vice-ChairDrs. James B. Barnes, Frederick C. Bisch, Casey M. Campbell, Margaret Hill, Robert A. Faiella, Cristina Cunha Villar, and S. Jerome Zackin.(2001) Glossary of Periodontal terms (4th edition) American Academy of Periodontology.
[21] Wikesjo UM, Susin C, Qahash M, Polimeni G, Leknes KN, Shanaman RH, Prasad HS, Rohrer MD, Hall J. (2006) The critical-size supraalveolarperi-implant defect model: characteristics and use. Journal of Clinical Periodontology, 33(11):846–854.http://dx.doi.org/10.1111/j.1600-051X.2006.00985.x.
[22] Kaynak D, Meffert R, GunhanM,Gunhan O.(2005) A histopathologic investigation on effects of electrical stimulation on periodontal tissue regeneration in experimental bony defects in dogs. Journal of Periodontology, 76(12):2194-2204.http://dx.doi.org/10.1902/jop.2005.76.12.2194.
[23] Jamil A. (1985) Recombinant Human Bone Morphogenetic Protein-2 in Implant Surgery– Alveolar Ridge Augmentation. Journal of Dental Research, 11:324-329.
[24] Sigurdsson TJ, Lee MB, Kubota K, Turek TJ, Wozney JM, Wikesjo UM. (1995) periodontal repair in dogs: recombinant human bone morphogenetic protein-2 significantly enhances periodontal regeneration. Journal of Periodontology, 66(2); 131-138. http://dx.doi.org/10.1902/jop.1995.66.2.131.
[25] Giannobile WV, Ryan S, Shih MS, Su DL, Kaplan PL, Chan TC.(1998) Recombinant human osteogenic protein-1 stimulates periodontal wound healing in class III furcation defects. Journal of Periodontology, 69(2):129-137.http://dx.doi.org/10.1902/jop.1998.69.2.129.
[26] Ripamonti U, Helitosis M, Van den Heever B, Reddi AH. (1999) Bone morphogenetic proteins induce periodontal regeneration in baboon (Papioursinus). Journal of Periodontal Research; 29 (6):439-445.http://dx.doi.org/10.1111/j.1600-0765.1994.tb01246.x.
[27] King GN, Cochran DL. (2002) Factors that modulate the effects of bone morphogenetic protein-induced periodontal regeneration: A Critical Review. Journal of Periodontology, 73(8):925-936.http://dx.doi.org/10.1902/jop.2002.73.8.925.
[28] King GN, Hughes FJ. (2001) Bone morphogenetic protein-2 stimulates cell recruitment and cementogenesis during early wound healing. Journal of Clinical Periodontology, 28(5):465-475.http://dx.doi.org/10.1034/j.1600-051x.2001.028005465.x.
[29] King GN, Hughes FJ. (1999) Effects of occlusal loading on ankylosis, bone, and cementum formation during bone morphogenetic protein-2-Stimulated periodontal regeneration in vivo. Journal of Periodontology, 70(10):1125-1135.http://dx.doi.org/10.1902/jop.1999.70.10.1125.
[30] Ripamonti U, Renton L. (2006) Bonemorphogenetic proteins and the induction of periodontal tissue regeneration. Periodontology 2000, 41:73-87.http://dx.doi.org/10.1111/j.1600-0757.2006.00155.x.
[31] Wikesjo UME, Xiropaidis AV, Thomson RC, Cook AD, Selvig KA, Hardwick WR. (2003) Periodontal repair in dogs: space providing ePTFE devices increase rhBMP-2 induced bone formation. Journal of Clinical Periodontology, 30(8):715-725.http://dx.doi.org/10.1034/j.1600-051X.2003.00364.x.
[32] Wikesjo UM, Sorensen RG, Kinoshita A, Jian Li X, Wozney JM. (2004) Journal of Clinical Periodontology, 31(8):662-70.http://dx.doi.org/10.1111/j.1600-051X.2004.00541.x.
[33] Odajima T, Morita M, Kawanami M, Kato H.(2005) Journal of Periodontal Research, 40 (4):299-305.http://dx.doi.org/10.1111/j.1600-0765.2005.00794.x.
[34] Position paper (1996).The potential role of growth and differentiation factors in periodontal regeneration. Journal of Periodontology, 67(5):545-553.
[35] Yang L, Zhang Y, Dong R, Peng L, Liu X, Wang Y, Cheng X. (2010) Effects of adenoviral-mediated co-expression of bone morphogenetic protein-7 and insulin-like growth factor-1 on human periodontal ligament cells. Journal of Periodontal Research, 45(4):532-40.
[36] Li YF, Yan FH, Zhong Q, Zhao X. (2010) Effect of hBMP-7 gene modified bone marrow stromal cells on periodontal tissue regeneration, Zhonghuayixuezazhi 25; 90(20):1427-30.
[37] Lee J, Stavropoulos A, Susin C, Wikesjo UM. (2010) periodontal regeneration: focus on growth and differentiation factors. Dental Clinics of North America., 54(1):93-111. http://dx.doi.org/10.1016/j.cden.2009.09.001.
[38] Ripamonti U, Petit JC. (2009) Bone morphogenetic proteins, cementogenesis, myoblastic stem cells and the induction of periodontal tissue regeneration. Cytokine &Growth Factors Reviews, 20(5-6):489-99.http://dx.doi.org/10.1016/j.cytogfr.2009.10.016.
[39] Jung RE, Windisch SI, Eggenschwiler AM, Thoma DS, Weber FE, Hammerle CH. (2009) a randomized-controlled clinical trial evaluating clinical and radiological outcomes after 3 and 5 years of dental implants placed in bone regenerated by means of GBR techniques with or without the addition of BMP-2. Clinical Oral Implants Research, 20(7):660-6.http://dx.doi.org/10.1111/j.1600-0501.2008.01648.x.
[40] Wikesjo UM, Qahash M, Huang YH, Xiropaidis A, Polimeni G, Susin C. (2009) Bone morphogenetic proteins for periodontal and alveolar indications; biological observations - clinical implications Orthodontics and Craniofacial Research, 12(3):263-70.http://dx.doi.org/10.1111/j.1601-6343.2009.01461.x.
[41] Wikesjo UM, Qahash M, Polimeni G, Susin C, Shanaman RH, Rohrer MD, Wozney JM, Hall J. (2008) Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-2: histologic observations. Journal of Clinical Periodontology, 35(11):1001-10.http://dx.doi.org/10.1111/j.1600-051X.2008.01321.x.
-
Downloads
-
-
How to Cite
Potharaju, S. P., Prathypaty, S. K., Chintala, R. K., Yendluri, D. B., & Kolliboyana, J. K. S. (2016). Role of bone morphogenetic proteins in periodontal regeneration- a review. International Journal of Health, 4(2), 141-144. https://doi.org/10.14419/ijh.v4i2.6374
