Antipyretic, analgesic and anti-inflammatory activity of the methanol Mimosa himalayana extract

  • Authors

    • Md. Hossain Department of PharmacySouthern University BangladeshMehedibag-4000, Chittagong
    • Md. Bashar Department of PharmacySouthern University BangladeshMehedibag-4000, Chittagong
    • Mohammed Ibrahim Department of PharmacySouthern University BangladeshMehedibag-4000, Chittagong
    • Muhammad Islam Department of PharmacySouthern University BangladeshMehedibag-4000, Chittagong
    2017-03-07
    https://doi.org/10.14419/ijm.v5i1.7331
  • Medicinal Plant, Phytochemical Screening, Pharmacological Activities.
  • The aim of the study was to evaluate antipyretic, analgesic and anti-inflammatory activities of the methanol extract of Mimosa himalayana Gamble (Fabaceae) along with a preliminary phytochemical screening. The antipyretic and analgesic effects were tested in Swiss mice, while anti-inflammatory in egg albumin, taking paracetamol, diclofenac sodium and acetyl salicylic acid as standards, respectively. The results suggest that, the crude stem extract of M. himalayana revealed the presence of alkaloids, glycosides, saponins and gums. It exhibited antipyretic and analgesic activity at 200 and 400 mg/kg, while anti-inflammatory at 40, 80 and 160 µg/mL in the test systems. The activities were significant (p <0.05) in comparison to the negative control group with a high dose/concentration-mediated higher response manner. We suppose the alkaloids and glycosides may contribute its anti-inflammatory potential, which may link to the antipyretic and analgesic effects of the M. himalayana. In conclusion, M. himalayana may be one of the best sources of plant-based medicines, especially anti-inflammatory agents.

  • References

    1. [1] http://www.zipcodezoo.com/Key/Plantae/Fabaceae_Family.asp.

      [2] http://zipcodezoo.com/Plants/M/Mimosa_himalayana/Default.asp.

      [3] Mahmood A, Mahmood A, Qureshi RA. Antimicrobial activities of three species of family mimosaceae. Pak J Pharm Sci 2012; 25:203-206.

      [4] Rao VR, AroraRK. Rationale for conservation of medicinal plants. pp. 7-22 in Batugal PA et al. (Eds.) Medicinal Plants Research in Asia. Vol 1: the Framework and Project Work Plans. International Plant Genetic Resources Institute (IPGRI), KualaLumpur. 2014

      [5] Islam MT, Mata AMOF, Aguiar RPS, Paz MFCJ, Alencar MVOB, Melo-Cavalcante AAC. Therapeutic potential of essential oils focusing on diterpens. Phytother Res 2016a; 30:1420-1444. https://doi.org/10.1002/ptr.5652.

      [6] Evans WC, Trease WC. Pharmacognosy. London: WB Saunders Ltd. 2002; pp. 32, 33, 95-99, 512, 547.

      [7] Ali M. Text Book of Pharmacognosy. New ed. CBS Publishers and Distributors. New Delhi, India. 2009; pp. 96, 97, 140, 283.

      [8] Sultana N, Islam MT, Alencar MVOB, Silva SWC, Chowdhury MU, Melo-Cavalcante AAC, Freitas RM. Phyto-pharmacological screenings of two Rubiaceae family plants. Afric J Pharm Pharmacol 2015; 9:775-782. https://doi.org/10.5897/AJPP2015.4313.

      [9] Pourmotabbed A, Farshchi A, Ghiasi G, Khatabi PM. Analgesic and anti-inflammatory activity of Teucriumchamaedrysleaves aqueous extract in male rats. Iranian J Basic Med Sci 2010; 13:119-125.

      [10] Ripon SS, Mahmood A, Chowdhury MMU, Islam MT. Evaluation of antioxidant, anti-inflammatory capacities and a possible anti-atherothrombosis activity of the methanol leaf extract of Clerodenrum viscosum. Adv Biomed Pharm 2016; 3:366-372. https://doi.org/10.19046/abp.v03i06.02.

      [11] Clark WG. Mechanism of antipyretic action. General Pharmacology: The Vascular System 1979; 10:71-77. https://doi.org/10.1016/0306-3623(79)90038-7.

      [12] Islam MT, Alencar MVOB, Mata AMOF, Paz MFCJ,Matos LA, Sousa JMC, Melo-Cavalcante AAC. Coffee: A health fuel-blot popular drinking. Int J Pharm PharmSci 2016b; 8:1-7. https://doi.org/10.22159/ijpps.2016v8i12.14510.

      [13] Musa YM, Haruna AK, Ilyas M, Yaro AH, Ahmadu AA, Usman H. Phytochemical, analgesic and anti-inflammatory effects of the ethylacetate extract of the leaves of Pseudocedrella kotschyii. Afr J Trad Compliment Alt Med 2008; 5:92-96. https://doi.org/10.4314/ajtcam.v5i1.31261.

      [14] Nur T, Islam MT, Alam S, M. Chowdhury MMU, Melo-Cavalcante AAC, Freitas RM. Pharmacological investigations of organic crude fractions of Dysophylla auricularia. Orient Pharm Exp Med 2015; 15:207-215. https://doi.org/10.1007/s13596-015-0190-x.

      [15] Sidaye RV, Dhanawade AE, Mansha K, Aishwarya G. Synthesis anti-microbial and antimycobacterial activity of nicotinic-acid hydrazide derivatives. Curr Pharm Res 1973; 1:135-139.

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    Hossain, M., Bashar, M., Ibrahim, M., & Islam, M. (2017). Antipyretic, analgesic and anti-inflammatory activity of the methanol Mimosa himalayana extract. International Journal of Medicine, 5(1), 87-89. https://doi.org/10.14419/ijm.v5i1.7331