Severe Ulcerative Colitis Flare Unmasking Factor VII Deficiency

  • Authors

    • Paul Muna Aguon Banner University Medical Center - Phoenix
    • Tyler Aasen Banner University Medical Center - Phoenix
    • Kaivan Salehpour Banner University Medical Center - Phoenix
    • Scott Mcshane Lankenau Medical Center
    2018-02-07
    https://doi.org/10.14419/ijm.v6i1.8840
  • Gastrointestinal Bleeding, Ulcerative Colitis, Factor VII Deficiency.

  • We present a 22-year-old male with severe bleeding from Ulcerative Colitis. Workup revealed anemia and elevated prothrombin time, with subsequent mixing study and clotting factor levels revealing factor VII deficiency. Bleeding disorders such as Factor VII deficiency may exacerbate the degree of hemorrhage in inflammatory bowel disease flares, making prompt recognition of underlying coagulopathies crucial.

  • References

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      [2] Mariani G, Bernardi F. Factor VII Deficiency. Seminars in Thrombosis and Hemostasis 2009; 35: 400-406. https://doi.org/10.1055/s-0029-1225762.

      [3] Lapecorella M, Mariani G. Factor VII deficiency: defining the clinical picture and optimizing therapeutic options. Haemophilia 2008; 14(6): 1170-1175. https://doi.org/10.1111/j.13652516.2008.01844.x.

      [4] Sevenet P, Kaczor DA, Depasse F. Factor VII Deficiency: From Basics to Clinical Laboratory Diagnosis and Patient Management. Clin Appl Thromb Hemost 2016. https://doi.org/10.1177/107 6029616670257.

      [5] Freeney M, Talbot R, Worsley A, Snook J. Crohn’s disease and inherited coagulopathy: two case reports. Ital J Gastroenterol Hepatol 1998; 30(4): 442.

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  • How to Cite

    Muna Aguon, P., Aasen, T., Salehpour, K., & Mcshane, S. (2018). Severe Ulcerative Colitis Flare Unmasking Factor VII Deficiency. International Journal of Medicine, 6(1), 11-12. https://doi.org/10.14419/ijm.v6i1.8840