Investigation on protective effects of Cressa cretica extract in scopolamine- induced memory impairment

 
 
 
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  • Abstract


    The present study was undertaken to investigate the effects of Cressa cretica on learning and memory in mice. Elevated plus maze and passive avoidance paradigm were utilized to test learning and memory. Two doses (200 and 400 mg/kg, p.o.) of ethanolic extract were administered for 28 successive days in separate group of animals. The dose of 400?mg/kg p.o. of CCE (Cressa cretica extract) significantly improved learning and memory of mice. Furthermore, this dose significantly reversed the amnesia induced by Scopolamine (0.4 mg/kg, i.p.). To find out the mechanism by which CCE exerts nootropic activity, the effect of CCE on whole brain AChE activity was also estimated. CCE also decreased whole brain acetyl cholinesterase activity. Antioxidant properties and presence of flavonoids in Cressa cretica may be contributing to memory enhancement effect. Here, Piracetam (200 mg/kg, i.p) was used as a standard nootropic agent. Hence Cressa cretica appears to be a promising candidate for improving memory and it would be worthwhile to explore the potential of this plant in the management of dementia and Alzheimers disease. However, further studies are necessitated to identify the exact mechanism of action.

    Keywords: Cressa cretica, Alzheimers disease, Central nervous system (CNS), Elevated plus maze, Passive avoidance apparatus.

  • References


      Chaudhary S, Khosa RL, Priyank & Rani S (2012), A report on Pharmacognostical and quality control parameters of stem and root of Cressa cretica Linn, Convolvulaceae. Journal of Pharmacy Research 5(1) 616-621.
    1. Chaudhary S & Khosa RL (2010), Evaluation of antidiabetic activity of Cressa cretica Linn in alloxan induced diabetes in rats. Pharmacologyonline 31, 81-188.
    2. Dhingra D, Parle M & Kulkarni SK (2004), Memory enhancing activity of Glycyrrhiza glabra in mice. Journal of Ethnopharmacology 91, 361365.
    3. Gupta RS & Kachhawa JBS (2006), Effect of Cressa cretica Linn. methanolic extract on testicular function of albino rats. Pharmaceutical Biology 44(5), 382-88.
    4. Kulkarni PD, Ghaisas MM, Chivatbe ND & Sankpal PS (2011), Memory enhancing activity of Cissampelos pariera in mice. International Journal of Pharmacy and Pharmaceutical Sciences 3, 206-211.
    5. Papandreou MA, Tsachaki M, Efthimiopoulos S, Cordopatis P, Lamari FN & Margarity M (2011), Memory enhancing effects of saffron in aged mice is correlated with antioxidant protection. Behavioural Brain Research 219, 197204.
    6. Priyashree S, Jha S & Pattanayak SP (2012), Bronchodilatory and mast cell stabilising activity of Cressa cretica L.: evaluation through in vivo and in vitro experimental models. Asian Pac J Trop Med. 5(3), 180-6.
    7. Rani S, Chaudhary S, Singh P, Mishra G, Jha KK & Khosa RL (2011), Cressa Cretica Linn: An Important Medicinal Plant-A Review on Its Traditional Uses, Phytochemical and Pharmacological Properties. Journal of Natural Product and Plant Resources 1(1), 91-100.
    8. Shahat AA & Nazif MN (2005), Flavonoids from Cressa cretica, Qatar University.Science.Journal, 25, 72-77.
    9. Suganthi G, Sripathy SK & Manian K (2008), HPTLC and Antibacterial analysis of extracts of Cressa cretica Linn. Ancient Science of Life 27(3), 114.
    10. Sunita P, Jha S & Pattanayak SP (2011), Anti-inflammatory and In-vivo Antioxidant Activities of Cressa cretica Linn, a Halophytic Plant. Middle-East Journal of Scientific Research 8(1), 129-140.
    11. Sunita P, Jha S & Pattanayak SP (2009), In-vitro Antitussive Activity of Cressa cretica Linn. Using Cough Model in Rodents. Pharmacognosy Research 1, 3, 152156.
    12. Xu J, Rong S, Xie B, Sun Z, Zhang L, Wu H, Yao P, Zhang X, Zhang Y & Liu L (2009), Rejuvenation of antioxidant and cholinergic systems contributes to the effect of procyanidins extracted from the lotus seedpod ameliorating memory impairment in cognitively impaired aged rats. European Neuropsychopharmacology 19, 851860.

 

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Article ID: 1387
 
DOI: 10.14419/ijpt.v2i1.1387




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