Ethno medicinal, phytochemical and pharmacological aspects of solanum incanum (lin.)
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2014-03-05 https://doi.org/10.14419/ijpt.v2i2.1454 -
Abstract
Solanum incanum is used in Africa and other parts of world as a folklore remedy for various ailments that include; sore throat, angina, stomach ache, ear inflammation, snake bites, wounds, liver disorders, skin ailments (ringworm), warts, inflammatory conditions, painful periods and fever.
Phytochemical studies of this herb indicate that it contains substances such as steroidal alkaloids, glyco-alkaloids, antioxidants (flavonoids and chlorogenics), saponins and even carcinogenic substances. The herbal extract posses’ antinociceptive, antipyretic, anti-spasmolytic, orexic, anorexic, hypoglycemic, antimicrobial, anti-schistosomal, anti-fungal, and anti-cancer activity.
The herb is therefore likely to be a major source of novel, affordable and effective therapeutic substances against myriad ailments afflicting people in the world.
This review explores the phyto-pharmacological effects of the S. incanum and compiles vital information that may assist researchers on what is known about this herb and gaps for further investigation.
Keywords: Anticancer, Antimicrobial, Antinociceptive, Antipyretic, Solanum Incanum.
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References
- Alamri SA and Moustafa .F (2012), Antimicrobial properties of 3 medicinal plants from Saudi Arabia against some clinical isolates of bacteria, Saudi Med. J. 33(3) (272-277.
- Anaso H U and Ouzo (1990), Relationship and Classification among Solanum incanum Complex, Cytologia (55) 1-14.
- Assefa A, Urga K, and Guta A, et al. (2006), Spasmolytic Activity of the Aqueous Root Extract of Solanum incanum, Solanaceae., Ethiop J Biol Sci (5) 2.
- Auta R and Ali I (2011), Nutritional and chemical value of Solanum incanum (bitter garden egg), Intern. J. Trop. Med. Pub. Health 1(1) 96-107.
- Britto SJand Senthinkumar S (2001), Antimicrobial activities of Solanum incanum leaf extract, Asian J. Microbio. Biotechn. Environ. Sci. 3(1-2) 65-66.
- Bussmann RW, Gilbreath GG, Solio J, et al. (2006), Plant use of the Maasai of Sekenani valley Maasai Mara, J. Ethnobiol. And Ethnomed. (2) 22.
- Chia-Hua L, Li-Feng L, Li-Yen S, Yu-Sheng H, Li-Ching C,.Kou-Wha K (2004), Action of solamargine on TNFs & cisplatin-resistant human lung cancer cells, Biochem Biophys Res. comm. 322(3)751-758.
- Ding X, Zhu F, Li min, Gao S (2012), Induction of apoptosis in human hepatoma SMMC-7721 cells by solamargine from Solanum nigrum, J. Ethnopharm. 139(2) 599- 604.
- Dold A P and Cocks ML (2000), The medical use of some weeds, problem and alien plants in the Graham’s town and Peddie district of Eastern Cape S.A, S. A. J. Sci. 96467- 473.
- Eltayeb EA, Al-Ansari, Roderick JG (1997), Changes in steroidal alkaloid Solasodine during development of Solanum nigrum & Solanum incanum, Phytochemistry 46(3) 489– 494.
- Hsu SH, Tsai SH, Lin CN, Yen MH, Kuo KW (1996), Solamargine purified from Solanum incanum Chinese herb triggers gene expression of human TNFR I which may lead to cell apoptosis, Biochem. Biophys. Res. Comm. 229(1) 1-5.
- Kokwaro J O (1993), Medicinal plants of East Africa, 2nd Edition East Africa Literature Bureau, Nairobi, 222-223.
- Kupchan SM, Barbouti ST, Knox JK, Laucam CA (1965), BetaSolamarine; tumour inhibitor isolated from Solanum dulcamara, Science 150(3705) 827-1828.
- Kuo KW, Hsu SH, LiYP, et al. (2000), anticancer activity evaluation of the Solanum glycoalkaloid solamargine. Trig gering apoptosis in human hepatoma cells, Biochem. Pharmacology 60(12) 865-73.
- Le Bars D, Gozariu Mand Caddens (2001), Animal model of nociception, Pharmacol. Rev. (53) 597-652.
- Lin C, Lu C, Cheng M, Gan K, Won S (1990), The Cytotoxic principles of Solanum incanum, Natural Prod. 53(2) 513–16.
- Li-Feng L, Chia-Hua L, Shiu L, Wei-Ling L, Chih-Chao L, Kou-Wha K (2004), Action of solamargine on human lung Can-cer cells--enhancement of the susceptibility of cancer cells to TNFs, FEBS Letters 577(1-2) 67-74.
- Matu E.N (2008), Solanum incanum L, PROTA (Plant Resources of Tropical Africa), Wageningen Netherlands, Prota-base.
- Mbaya B and Muhammed S (1976), Antibiotic action of Solanum incanum L., Anti-microb. Agents Chemother. (6) 920-927.
- Michaud WA, Nichols AC, Mrozl EA et al. (2009), Bcl-2 blocks cisplatin-induced apoptosis and predicts poor outcome following chemoradiation treatment in advanced oropharyngeal squamous cell carcinoma, Clin. Cancer Res. 15(5) 1645-54.
- Muchika S, Kutima HL, Maranga RO and Yole DS (2011), An ti-schistosomal effects of Solanum incanum and Carica pa paya crude extracts on the parasite Schistosoma mansoni invivo and in vitro, Intern. J. Trop. Med. (7) 2.
- Musabayane CT, Bwititi, PT and Ojewole JA (2006), Ef-fects of oral administration of some herbal extracts on food consumption and blood glucose levels in normal and strepto zotocin-treated diabetic rats, Methods find Exper. Clin Pharma-col. 28(4) (223-228.
- Mwonjoria, JK, Kariuki H and Waweru FN (2011), the antinociceptive antipyretic effects of Solanum incanum (Lin.) in animal models, Intern. J. Phytopharm. 2(1) 22-26.
- Roddick JG, Rijneberg AL,Weissenberg M (1990), Membrane disrupting properties of the steroidal glycoalkaloids solasomine and solamargine, Phytochemistry 29(5) 1513-1518.
- Ross JS and Fletcher A (1998), The HER-2/neu oncogene in breast cancer: prognostic factor, predictive factor, and target for therapy, Stem cells 16(6) 413-28.
- Salah W, Miller NJ, Pagauga G et al. (1995), Polyphenolic flavornols as scavenger of aqueous phase radicals and Chain breaking antioxidants, Arch. Biochem. Bio. 2 339-346.
- Shiu LY, Chang LC, Liang CH, Huang YS, Sheu HM, and Kuo KW (2007), Solamargine induces apoptosis and sensitizes breast cancer cells to cisplatin, Food chem. Toxic. 45(11) 2155–2164.
- Shiu LY, Liang CH, Huang YS, Sheu HM, Kuo KW (2008), down regulation of Her2/neu receptor by solamargine en hances anticancer drug-mediated cytotoxicity in breast cancer cells with high expressing Her2/neu, Cell Biol. Toxic. 24(1) 1-10.
- Sun L, Zhao Y, Yuan H, Li X, Cheng A, Hongxiang L (2011), Solamargine, a steroidal alkaloid glycoside, induces oncosis in human K562 leukemia and squamous cell carcinoma KB cells, Cancer Chemother. Pharm. 67(4) 813-821.
- Taye B, Giday M, Animut A, Seid A (2011), Antimicrobial activity of selected plants in traditional treatment of wounds in Ethiopia, Asian Pacific J. Trop. Bio Med. 370- 375
- Thaiya AG, Nyaga PN, Maribei,JM, Nduati D, Mbuthia PG and Ngatia TA (2010), Experimental Solanum incanum L. poisoning in goats [abstract], Bull. Animal Health Prod. Africa (58) 1.
- Uchenna OV, Chinwe OE, Ijeoma EO, Ezenduka PO (2009) Investigation of the effect of Solanum incanum on postprandial blood glucose concentration of normoglycemic Nigerians, Pakistan J Nutri. (8) 1631-1635.
- Weiya XC, Jin-Shing, X, Zhou et al. (2004), Phosphorylation / cytoplasmic localization of p21Cip1/WAF1 is associated with her2/neu over- expression and provides a novel combination predictor for poor prognosis in breast Cancer patients, Clin. Cancer Res. (10) 3815-3824.
- Xia L, Zho Y, Mei J, Liu S, CUI min, Lou Hong X (2011), Induction of actin disruption and down regulation of P-glycoprotein expression by solamargine in multiple drugs resistant K562/A02 cells, Chin. Med. J. 124(13) 2038-2044.
- Yun-lian L, Wan-yi W, Kuo YH (2000) Non-steroidal constituents from Solanum incanum, Chin. Chem. Soc. (47) 247- 251.
- Zhou Y, Gao W, Likenfeng (2008), Chinese herbal medicine in treatment of liver cancer, Asian J Trad. Med. (1) 1-11.
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How to Cite
Mwonjoria, J. K., Ngeranwa, J. J., Kariuki, H. N., Githinji, C. G., Sagini, M. N., & Wambugu, S. N. (2014). Ethno medicinal, phytochemical and pharmacological aspects of solanum incanum (lin.). International Journal of Pharmacology and Toxicology, 2(2), 17-20. https://doi.org/10.14419/ijpt.v2i2.1454Received date: 2013-10-28
Accepted date: 2013-11-24
Published date: 2014-03-05