Potential anti-diabetic property of the aqueous extract of the leaves of Saba senegalensis Pichon (apocynaceae) in mice

  • Authors

    • Dosso Mamadou Peleforo Gon coulibaly University
    • coulibaly Adama Peleforo Gon Coulibaly University
    • Coulibaly Ousmane Félix Houphouët-Boigny National Polytechnic Institute (INP-HB
    • Soro Doudjo Félix Houphouët-Boigny National Polytechnic Institute (INP-HB)
    • N'guessan J. David Félix Houphouët-Boigny University
  • Saba Senegalensis, Antidiabetic, Hypoglycemic, Antihyperglycemic, Mouse.
  • This study made it possible to demonstrate that Saba senegalensis has hypoglycemic and anti-hyperglyvemic effects in mice. The aqueous extract of Saba senegalensis from 75 to 250 mg / Kg bw causes a dose-dependent hypoglycemia ranging from 4.84 to 34.62% (p <0.01-0.05), in normoglycemic mice, 60 minutes after treatment. The Glucose-Induced Hyperglycemia Orally (OPGH) test showed that in the presence of Saba senegalensis aqueous extract at a concentration between 75 and 250mg/Kg bw, the glucose-induced hyperglycemic peak (3g/Kg bw) is reduced from 26.49 to 71.77% (p < 0.01-0.05), 30 minutes after treatment. Oral administration of the aqueous extract of this plant in doses up to 5000 mg / Kg bw resulted in no deaths in mice during two weeks of observation.




  • References

    1. [1] American Diabetes Association (2002). Screening for Diabetes. Diabetes. Care 4 (25) Supplement1 : S21-S24 https://doi.org/10.2337/diacare.25.2007.S21.

      [2] Dénou A, Sawadogo Y, Haïdara M. Togola A.Sanogo R. Diallo D(2016). Activité antidiabétique des racines de Zizyphus mauritiana Lam (Rhamnaceae) et des feuilles de Zizyphus mucronataWilld chez le lapin. Int. J. Multidiscip. Res. Dev. 3(6) :24-26 http://www.allsubjectjournal.com/ doi.org/10.22271/ijmrd.

      [3] Kambouche N, Merah B, Derdour A., Bellahouel S., Younos C., Soulimanl R (2011). Activité antihyperglycémiante d’un stérol β-sitoglucoside isolé de la plante Anabasis articula (Forssk) Moq. Phytothérapie 9 : 2-6 https://doi.org/10.1007/s10298-010-0603-4.

      [4] Marles JR, Fransworth NR (1994). Plants as sources of antidiabetic agents. Econ Med Plant Res (6) : 150-85.

      [5] N’Doua L A. R, Abo K.J.C, Aoussi S. Gbogbo M. Yapo A.P. Ehile E.E. (2015) Effets hypoglycémique et antihyperglycémique de l’extrait 70% de racines de Raufolvia vomitoria afzel (Apocyanaceae). European Scientific Journal 11(6) : 176-190. https://eujournal.org/index.php/esj/article/viewFil.

      [6] Arbonnier M (2002). Arbres, arbuste et lianes des zones sèches de l’Afrique de l’ouest. 2nd Ed CIRAD-France 573 p.

      [7] SARR M.G, Ndiaye N.D, Ayessou N.C, Faye P.G, Cisse M. Sakho (2018) M. Saba senegalensis : Key features and Use. Food and Nutrition Sciences (9) : 1099-1111 https://www.scirp.org/Journa https://doi.org/10.4236/fns.2018.99080.

      [8] Eklu-Natey RD, Balet A. (2018) Pharmacopée Africaine. Dictionnaire et Monographies Multilingues du potentiel Médicinal des plantes Africaines. Afrique de l’Ouest Edition d’en bas- traditions et Médecine TM : Genève volume 2.

      [9] SARR OR, Fall AD, Gueye R. Diop F. Sene B. Diatta K. (2015) Evaluation de l’activité antioxydante des feuilles de Alpinia senegalensis (Sapindaceae) et de Saba senegalensis (Apocyanaceae). Int. J. Biol. Chem. Sci 9(6) : 2676-2684 https://www.ajol.info/index.php/ijbcs/article/view https://doi.org/10.4314/ijbcs.v9i6.13.

      [10] Magassouba F.B., Dialo A., Kouyaté M., Mara F. Mara O. Bangoura A. (2007) Ethnobotanical survey and antibacterial activity of some plants used in Guinean traditional medicine. J Etnopharmacol 144 :44-53. https://doi.org/10.1016/j.jep.2007.07.009.

      [11] Traore A, Ouedraogo S, Lompo M, Traoré S, Some N, Guissou IP. (2013) Ethnobotanical survey of medicinal plants used to treat gastrointestinal parasites in humain and livestock in four geographics areas of Burkina Faso (west Africa). Arch Appl Sci Res 5(6): 172-7. https://www.semanticscholar.org/paper/Ethnobotanical-survey-of-medicinal-plants-used-to-t-Traoré-Ouédraogo/.

      [12] Boamponsem GA, Johnson FS, Mahunu GK. Awiniboya S.F. (2013) Détermination of biochemical composition of Saba senegalensis (Saba fruit). Asian Journal of plant science and Research. 3(1) :31-36 https://www.imedpub.com/articles.

      [13] Masunda T.A, Mbala M.B, Kayembe S.J., Longoma B.F., Ngbolua K.N., Tshibangu D.S.T. et al. (2014) Activité anti-hyperglycémique et antiradicalaire des extraits des fruits de Raphia gentilina de Wild (Arecaceae).Int.J.Biol.Chem.Sci 8(6):2441-2451 https://www.ajol.info/index.php/ijbcs/article/view/. https://doi.org/10.4314/ijbcs.v8i6.7.

      [14] Kambouche N, Merah B, Derdour A. Bellahouel M.M, Benziane C,Younos M., et al. (2009) Etude de l’effet antidiabétique des saponines extradites d’Anabasis articula (Forssk) Moq, plante utilisée traditionnellement en Algérie. Phytothérapie 7: 197-201 · https://www.semanticscholar.org/paper/ https://doi.org/10.4314/ijbcs.v8i6.7.

      [15] Talbert M, Willoquet G, Gervais R. (2009) Le guide pharmaco clinique. Wolter Kluwer France 1090 p

      [16] Shimizu M, Kobayashi Y, Suzuki M. Satsu H. Miyamoto Y. (2000) Regulation of intestinal glucose transport by tea catechins. Biofactors 13 : 61-65. https://www.researchgate.net/publication/. https://doi.org/10.1002/biof.5520130111.

      [17] Ovaskainen ML, Torronen R, Koponen JM, Sinkko H, Hellstrom J, Reinvuo H, et al. (2008) Dietary intake and major food sources of polyphenols in finish adults. J. Mol. Sci 138 : 562-80 https://www.ncbi.nlm.nih.gov/pubmed/. https://doi.org/10.1093/jn/138.3.562.

      [18] Singh R. (2010) Antihyperglycemic effect of ethanolic extract and fractions of Anacardium Occidentale L. stem bark in streptozotocin-induced diabetic rat. Journal of Basic and Clinical Pharmacy 1(1) :16-19.

      [19] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158895/pdf/JBCP-1-16.pdf.

      [20] Clarke E.G.C, Clarke M.L. (1997) Veterinary Toxicology. Cassel and Colier Macmillan Publishers, London; pp268-277.

  • Downloads

  • How to Cite

    Mamadou, D., Adama, coulibaly, Ousmane, C., Doudjo, S., & J. David, N. (2020). Potential anti-diabetic property of the aqueous extract of the leaves of Saba senegalensis Pichon (apocynaceae) in mice. International Journal of Pharmacology and Toxicology, 8(1), 65-69. https://doi.org/10.14419/ijpt.v8i1.30635