Potential anti-diabetic property of the aqueous extract of the leaves of Saba senegalensis Pichon (apocynaceae) in mice

Authors

  • Dosso Mamadou Peleforo Gon coulibaly University
  • coulibaly Adama Peleforo Gon Coulibaly University
  • Coulibaly Ousmane Félix Houphouët-Boigny National Polytechnic Institute (INP-HB
  • Soro Doudjo Félix Houphouët-Boigny National Polytechnic Institute (INP-HB)
  • N'guessan J. David Félix Houphouët-Boigny University

DOI:

https://doi.org/10.14419/ijpt.v8i1.30635

Published:

2020-05-16

Keywords:

Saba Senegalensis, Antidiabetic, Hypoglycemic, Antihyperglycemic, Mouse.

Abstract

This study made it possible to demonstrate that Saba senegalensis has hypoglycemic and anti-hyperglyvemic effects in mice. The aqueous extract of Saba senegalensis from 75 to 250 mg / Kg bw causes a dose-dependent hypoglycemia ranging from 4.84 to 34.62% (p <0.01-0.05), in normoglycemic mice, 60 minutes after treatment. The Glucose-Induced Hyperglycemia Orally (OPGH) test showed that in the presence of Saba senegalensis aqueous extract at a concentration between 75 and 250mg/Kg bw, the glucose-induced hyperglycemic peak (3g/Kg bw) is reduced from 26.49 to 71.77% (p < 0.01-0.05), 30 minutes after treatment. Oral administration of the aqueous extract of this plant in doses up to 5000 mg / Kg bw resulted in no deaths in mice during two weeks of observation.

 

 

 


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