In vitro cytotoxic activity of aqueous extract of Delonix elata (L.) gamble (fabaceae) leaves on mcf-7 & hep g-2 cell lines

  • Authors

    • Phani Kumar Kola Uiversity College of Pharmaceutical Sciences, Acharya Nagrjuna University, Guntur, A.P, India
    • Shyam Prasad K Uiversity College of Pharmaceutical Sciences, Acharya Nagrjuna University, Guntur, A.P, India
    • Lakshmi Sudeepthi N K.V.S.R Siddhartha College of Pharmaceutical Sciences, Vijayawada, Krishna District, AP, India.
    • R.CH.Sekhara Reddy D Uiversity College of Pharmaceutical Sciences, Acharya Nagrjuna University, Guntur, A.P, India
    • Abdul Rahaman Sk Nirmal College of pharmacy, Atmakur, Guntur, AP, India
    • Madan Ranjith P NRI College of pharmacy, Pothvarappadu, Agiripalli, Krishna District, AP,India.
  • To investigate, in vitro cytotoxic effect of aqueous extract of Delonix elata leaves belongs to family Fabaceae. The dried Delonix elata leaf extract was used to determine the qualitative preliminary phytochemical analysis and in vitro cytotoxic assay against breast cancer (MCF-7) & Hepatic cancer (HepG2) cells by using MTT assay method.  Phytochemical evaluation revealed the presence of flavonoids, tannins, phenolic compounds, steroids and saponins and this result was supported by IR data, which exhibits anticancer activity against breast and hepatic cancer cell lines. So the current investigation showed that Delonix elata leaf extract possesses the dose dependent cytotoxic activity against breast and hepatic cancer cell lines.

    Keywords: Delonix elata, Aqueous Extract, Flavonids, MCF-7 & Hep G2 Cell Line.

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    Kola, P. K., K, S. P., N, L. S., D, R. R., Sk, A. R., & P, M. R. (2014). In vitro cytotoxic activity of aqueous extract of Delonix elata (L.) gamble (fabaceae) leaves on mcf-7 & hep g-2 cell lines. International Journal of Pharmacology and Toxicology, 2(2), 70-75.