Dry gangrene of lower limbs in a child: an adverse drug reaction to chloramphenicol

  • Authors

    • Tanvir Samra PGIMER CHANDIGARH
    • Lalita Chaudhary
    • Ranvinder Kaur
    2014-10-23
    https://doi.org/10.14419/ijpt.v2i2.3299
  • Drug induced vasculitis is a potentially life and limb threatening complication which can be precipitated by intake of virtually any pharmaceutical agent. It is a diagnosis of exclusion as definitive diagnostic and laboratory criteria have not been defined. Withdrawal of the offending agent is the definitive therapy but use of antithrombotic, vasodilatory and anti-inflammatory agents has been proven to be beneficial. We report a case of dry gangrene of bilateral lower limbs and digits of the upper limb due to DIV secondary to the intake of chloramphenicol in a child diagnosed with typhoid fever.

    Keywords: Adverse Drug Reaction; Dry Gangrene; Chloramphenicol; Typhoid Fever; Drug Induced Vasculitis.

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    Samra, T., Chaudhary, L., & Kaur, R. (2014). Dry gangrene of lower limbs in a child: an adverse drug reaction to chloramphenicol. International Journal of Pharmacology and Toxicology, 2(2), 101-103. https://doi.org/10.14419/ijpt.v2i2.3299