Analgesic activity of the fractions of the aqueous extract of Ximenia Americana (Linné) (Olacaceae)

  • Authors

    • Soro tianga yaya University Felix Houphouët-Boigny (Côte D’Ivoire)
    • Zahoui Ouga Stanislas University Felix Houphouët-Boigny
    • Nene-bi Anthelme Semi University Felix Houphouët-Boigny
    2016-01-26
    https://doi.org/10.14419/ijpt.v4i1.5513
  • Ximenia Americana, Lysine Acetylsalicylate, Analgesic, Saponins.

  • Abstract

    This work is the continuation of previous work, during which we investigated the analgesic effects of aqueous extract of Ximenia americana in rats and mice. This work has shown the analgesic action of the aqueous extract of Ximenia americana, effect which seems be due to flavonoids and saponins contained in this total extract. We undertook the fractionation of the crude extract of Ximenia americana, to verify the assumption that the analgesic effect of the aqueous extract from Ximenia americana is due to flavonoids and saponins. To do this we used the fractionation method developed by wagner. This method gave us 6 fractions; we tested on rats and mice. The use of reference molecules such as morphine and phenylbutazone showed the analgesic properties of fractions F2, F4, F6 of the aqueous extract of Ximenia americana.

    Analgesic activity of the fractions of the aqueous extract of

     Ximenia Americana (Linné) (Olacaceae)

  • References

    1. [1] Alaoui K, Lagorce J F, Cherrah Y, Hassar M, Amarouch H & Roquebert J (1998) Activité analgésique et anti-inflammatoire des saponines d’Argania spinosa, in : Annales pharmaceutiques françaises, pp. 220–228.

      [2] Boullard B (2001) Plantes médicinales du Monde. Croyances et réalités. Editions ESTEM,pp. 565–566.

      [3] Chang J Y & Lewis A J (1989) Pharmacological methods in the control of inflammation. Modern Methods in Pharmacology 5, 195–212.

      [4] Collier H O J, Dinneen L C, Johnson C A & Schneider C (1968) The abdominal contraction response and its suppression by anti-nociceptive drugs in the mouse. British J. Pharmacol. Chemother 32, 295–310.http://dx.doi.org/10.1111/j.1476-5381.1968.tb00973.x.

      [5] D’Amour F E & Smith D L (1941) A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther 72, 74–79.

      [6] Deraedt R, Jougney S, Benzoni J & Peterfalvi M (1980) Release of prostaglandins E and F in algogenic reaction and its inhibition. Eur. J. Pharmacol61, 17–24.http://dx.doi.org/10.1016/0014-2999(80)90377-5.

      [7] Duarte J D G, Nakamura M & Ferreira S H (1988) Participation of the sympathetic system in acetic acid induced writhing in mice. Brazil.J. Med. Biol. Res 21, 341–343.

      [8] Dubuisson D & Dennis S G (1977) The formalin test: A quantitative study of the analgesic effect of morphine, meperidine, and brainstem stimulation in rats and cats. Pain 4, 161–174.http://dx.doi.org/10.1016/0304-3959(77)90130-0.

      [9] Gray W D, Osterberg A C & Scute J T (1970) Measurement of the analgesic efficacy and potency of pentazocine by the D’Amour and Smith method. J. Pharmacol. Exp. Ther 172, 154 –162.

      [10] Griswold D E, Marshall P, Martin L, Webb E F & Zabko-Potapovich B (1991) Analgesic activity of SK & F 105809, a dual inhibitor of arachidonic acid metabolism. Agents and Actions 32, 113–117.

      [11] Gupta M, Mazumder U K, Sambath Kumar R, Gomathi P, Rajeshwar Y, Kakoti B B & Tamil Selven V (2005) Anti-inflammatory, analgesic and antipyretic effects of methanol extract from Bauhinia racemosa stem bark in animal models. J. Ethnopharmacol 98, 267–273.http://dx.doi.org/10.1016/j.jep.2005.01.018.

      [12] Hokanson G C(1978)Acetic acid for analgesic screening. J. Nat. Prod 41, 497–498.

      [13] Kerharo J &Adam JC(1974) La pharmacopée sénégalaise traditionnelle. Plantes médicinale et toxiques. Ed. Vigot-Frères, Paris.

      [14] Koster R, Anderson M & De Beer J (1959) Acetic acid for analgesic screening. Federal Proceeding 8, 412– 417.

      [15] Mylari B L, Carty T J, Moore P F & Zembrowski W J (1990) 1,2-Dihydro-1-oxopyrrolo [3,2,1-kl] phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with anti-inflammatory activity. J. Med. Chem 33, 2019–2024.http://dx.doi.org/10.1021/jm00169a035.

      [16] Nasrin F, Hakim Md L, Pinon R M, Chakraborty M, Sarker N G & Alam K (2015) Analgesic study of methanolic extracts of loranthus europaeus leaf and stem. World journal of pharmacy and pharmaceutical sciences Volume 4, Issue 07, 11-19.

      [17] Neto A G, Costa J M L C, Belati C C, Vinholis A H C, Possebom L S, Da Silva Filho A A, Cunha W R, Carvalho J C T, Bastos J K & Silva M L A E (2005)Analgesic and anti-inflammatory activity of a crude root extract of Pfaffia glomerata (Spreng) Pedersen. J. Ethnopharmacol96, 87–91.http://dx.doi.org/10.1016/j.jep.2004.08.035.

      [18] Nguemfoa E L,Dimoa T, Azebaze A G B, Asongalem E A, Alaoui K, Dongmoe A B, Cherrah Y & Kamtchouing P (2007) Anti-inflammatory and anti-nociceptive activities of the stem bark extracts from Allanblackia monticola STANER L.C. (Guttiferae). J. Ethnopharmacol. 114, 417–424.http://dx.doi.org/10.1016/j.jep.2007.08.022.

      [19] Ojewole J A O (2007) Analgesic, anti-inflammatory and hypoglycemic effects of Rhus chirindensis (Baker F.) [Anacardiaceae] stem-bark aqueous extract in mice and rats. J. Ethnopharmacol 113, 338–345.http://dx.doi.org/10.1016/j.jep.2007.06.025.

      [20] Rajkumar G & Sellamuthu M, (2015) Analgesic and acetylcholinesterase inhibition potential of polyphenols from Scolopia crenata (Flacourtiaceae): An endemic medicinal plant of India. Industrial Crops and Products 73, 134–143http://dx.doi.org/10.1016/j.indcrop.2015.03.090.

      [21] Rioja I, Terenci M C, Ubeda A, Molina P, Tarraga A, Gonzalez-Tejero A & Alcaraz M J (2002) A pyrroloquinazoline derivative with anti-inflammatory and analgesic activity by dual inhibition of cyclo-oxygenase-2 and 5-lipoxygenase. Eur. J. Pharmacol 434, 177–185.http://dx.doi.org/10.1016/S0014-2999(01)01539-4.

      [22] Rosland J H, Tjolsen A, Maehle B & Hole K (1990) The formalin test in mice: Effect of formalin concentration. Pain 42, 235–242.http://dx.doi.org/10.1016/0304-3959(90)91167-H.

      [23] Sayyah M A, Hadidi N B & Kamalinejad M B (2004) Analgesic and anti-inflammatory activity of Lactuca sativa seed extract in rats. J. Ethnopharmacol 92, 325–329.http://dx.doi.org/10.1016/j.jep.2004.03.016.

      [24] Shibata M, Ohkubo T, Takahashi H & Inoki R (1989) Modified formalin test: characteristic biphasic pain response. Pain 38, 347–352.http://dx.doi.org/10.1016/0304-3959(89)90222-4.

      [25] Soro T Y, Traore F & Sakande J (2009) Activité analgésique de l’extrait aqueux de Ximenia americana (Linné) (Olacaceae). C. R. Biologies 332, 371–377.http://dx.doi.org/10.1016/j.crvi.2008.08.022.

      [26] Tjolsen A, Berge O G, Hunskaar S, Rosland J H & Hole K (1992) The formalin test: an evaluation of the method. Pain 51, 5–17.http://dx.doi.org/10.1016/0304-3959(92)90003-T.

      [27] Trongsakul S, Panthong A, Kanjanapothi D & Taesotikul T (2003) the analgesic, antipyretic and anti-inflammatory activity of Diospyros variegata Kruz. J. Ethnopharmacol 85, 221–225.http://dx.doi.org/10.1016/S0378-8741(03)00020-5.

      [28] Trongsakul S, Panthong A, Kanjanapothi D, & Taesotikul T (2003) the analgesic, antipyretic and anti-inflammatory activity of Diospyros variegata Kruz. J. Ethnopharmacol. 85, 221–225.http://dx.doi.org/10.1016/S0378-8741(03)00020-5.

      [29] Vasudevan M, Gunnam K K & Parle M (2007) Anti nociceptive and anti-inflammatory effects of Thespesia populnea bark extract. J. Ethnopharmacol 109, 264–270.http://dx.doi.org/10.1016/j.jep.2006.07.025.

      [30] Wagner H (1983) Drogen analyse, dünschicht chromatographische analyse von arzneidrogen. Springer Verlag Berlin heidelberg, New York.

      [31] Youmbie D D B, Dzeufiet D P D, Nkwengoua E, Mezui C & Dimo T (2015) Anti-inflammatory and anti-nociceptive effects of the stem bark aqueous extract of rauwolfia vomitoria (apocynaceae). World journal of pharmacy and pharmaceutical sciences, Volume 4, Issue 07, 90-112.

      [32] Young H, Luo Y, Cheng H, Hsieh W, Liao J & Peng W (2005)Analgesic and anti-inflammatory activities of [6]-gingerol. J. Ethnopharmacol 96, 207–210.http://dx.doi.org/10.1016/j.jep.2004.09.009.

      [33] Zirihi G N (2006) Etudes botanique, pharmacologique et phytochimique de quelques plantes médicinales anti-paludiques et/ou immunogènes utilisées chez les Bété du département d’issia, dans l’ouest de la Côte d’Ivoire, Thèse de Doctorat d’Etat ès science, Université Abidjan – Cocody.

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  • How to Cite

    tianga yaya, S., Ouga Stanislas, Z., & Anthelme Semi, N.- bi. (2016). Analgesic activity of the fractions of the aqueous extract of Ximenia Americana (Linné) (Olacaceae). International Journal of Pharmacology and Toxicology, 4(1), 1-6. https://doi.org/10.14419/ijpt.v4i1.5513

    Received date: 2015-11-06

    Accepted date: 2015-11-29

    Published date: 2016-01-26