Pattern of acute poisoning in teaching hospital, northwest Ethiopia
Keywords:Antidote, Management, Organophosphate, Poisoning.
Background: Acute poisoning is considered a major health problem worldwide and is a frequent cause of hospital admission. It is estimated that poisons are responsible for more than 1 million illnesses worldwide annually.
Objective: To evaluate retrospectively the pattern of acute poisoning in teaching hospital, northwest Ethiopia.
Materials and methods: This was an observational, retrospective study. The study population includes all patients who visiting Gondar teaching hospital emergency room who were diagnosed with acute poisoning from September 2010 to December 2014. All data were analyzed using SPSS 20.
Result: Acute poisoning cases constituted 0.67% of the 34320 admissions to the emergency department. Of these 233 patients, 148 (63.5%) were female and 85 (36.5%) were male.88.42% were younger than 30 years of age and the frequency of acute poisoning declined with advanced age. Organophosphates were the most frequent cause of poisoning and accounted for 89 cases (38.2%). Intentional poisoning comprised 57.5 %.83.6 %( 195 cases) of the cases were ingested orally, the mean arrival time to the emergency unit after poisoning was 4.2 hours and the average duration of hospital stay was 11.26hours. It was found that 60 % of the cases were simply received supportive therapy. The most common factors contributing to intentional poisoning was quarreled with their family (54.2%) followed by love affairs (18.4%). The mortality rate was 0.43%
Conclusions: The data observed in this hospital based shows acute poisoning remains a major public health problem with pesticide poisoning remaining the most common and therefore concerning poison.
 Pokhrel D, Pant S, Pradhan A, Mansoor S (2008) a comparative retrospective study of poisoning cases in central, zonal and district hospitals. Kathmandu university journal of science, engineering and technology I (V):40-8.
 Vivekanandan.K, Bhavya.E, K.Punitha, Anand V (2012) A study on poison cases and their management along with poison awareness educational strategies. Asian Journal of Pharmaceutical and Clinical Research 5(2).
 Lund C, Vallersnes OM, Jacobsen D, Ekeberg O, Hovda KE (2012) Outpatient treatment of acute poisonings in Oslo: poisoning pattern, factors associated with hospitalization, and mortality. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 20(1).http://dx.doi.org/10.1186/1757-7241-20-1.
 Mahabalshetti AD, Aithal KR, Patil BS, Kudari SS, Dhananjaya M (2013) Profile of acute poisoning cases at a tertiary care hospital. MedicaInnovatica 2(1).
 Peiris-John R, Kafoa B, Wainiqolo I, Reddy RK, McCaig E, Ameratunga SN (2013) Population-based characteristics of fatal and hospital admissions for poisoning in Fiji: TRIP Project-11. InjPrev 19:355-7.http://dx.doi.org/10.1136/injuryprev-2012-040651.
 Abd-Elhaleem ZAE, Muqhem BAA (2014) Pattern of acute poisoning in Al Majmaah region, Saudi Arabia. American Journal of Clinical and Experimental Medicine 2(4):79-85.
 Dines A, Archer J, Dargan P, Collignon U, Nash S (2007) Poisoning an overview of treatment. Hospital Pharmacist 14.
 Hanssens Y, Deleu D, Taqi A (2001) Etiologic and Demographic Characteristics of Poisoning: A Prospective Hospital-Based Study in Oman. Clinical Toxicology 39(4):371-80.http://dx.doi.org/10.1081/CLT-100105158.
 Tefera A, Y W (2006) the pattern of acute poisoning in a teaching hospital, north-west Ethiopia. Ethiop Med J 44(2):183-9.
 GÃ¼loÄŸlu C, Kara IH (2004) Cases of Acute Poisoning in Southeast Anatolia of Turkey. Dicle TÄ±p Dergisi 31(2):37-45.
 Hegazy R, Almalki WH, Afify RHM (2012) Pattern of Acute Poisoning in Makkah Region Saudi Arabia. The Egyptian Journal of Community Medicine 30(1).
 Hu Y-H, Chou H-L, Lu W-H, Huang H-H, Yang C-C, Yen DHT, et al (2010) Features and Prognostic Factors for Elderly With Acute Poisoning in the Emergency Department. J Chin Med Assoc73 (2):78-87.http://dx.doi.org/10.1016/S1726-4901(10)70006-X.
 SB K, SB A (2005) A study of poisoning cases in emergency Kathmandu Medical College Teaching Hospital. Kathmandu University Medical Journal 3(12):388-91.
 Cheung CY, Tat FH, Keung LC, Hon TS, Kwok NH, Yee SM, et al (2005) A prospective epidemiological study of acute poisoning in Hong Kong. Hong Kong jemergmed 12:156-61.
 B.R.Sharma, D.Harish, A.K.Sharma, Bangar S, Gupta M, Gupta N, et al (2010) Toxicological emergencies and thier management at different health care levels in Northern India-An overview. Journal of pharmacology and Toxicology 5(7):418-30.
 Singh OG, Singh AM (2014) Trends of poisoning cases in Melmaruvathur region of Tamil Nadu: A retrospective study of 3 years. IAIM 1(4):27-31.
 UB G, Tadvi NA, Hussain S (2015) A comparative overview of poisoning in multidimentional perspective. Int J Med Res Health Sci 4(1):203-7.http://dx.doi.org/10.5958/2319-5886.2015.00033.8.
 Moazzam M, Al-Saigul AM, Naguib M, Alfi MAA (2009) Pattern of acute poisoning in AlQassim region: a surveillance report from Saudi Arabia, 1999â€“2003. Eastern Mediterranean Health Journal 15(4).
 Jalali A, Savari M, Dehdardargahi S, Azarpanah A (2012) The Pattern of Poisoning in Southwestern Region of Iran: Envenoming as the Major Cause. Jundishapur J Nat Pharm Prod 7(3):100-5.http://dx.doi.org/10.17795/jjnpp-3504.
 Maharani B, Vijayakumari N (2013) Profile of poisoning cases in a Tertiary care Hospital, Tamil Nadu,India. Journal of Applied Pharmaceutical Science3 (01):091-4.http://dx.doi.org/10.7324/japs.2013.30117.
 Mar H, Mhi S, Mr a, Mg M, Ms I, Mz U, et al (2008) Clinico-epidemiological pattern of poisoning in a tertiary level hospital. J Dhaka Med Col17 (2):111-5.
 F K, Wv H, P P (2006) Reaching for the bottle of pesticide--a cry for help. Self-inflicted poisonings in Sri Lanka. SocSci Med 62(7):1710-9.http://dx.doi.org/10.1016/j.socscimed.2005.08.020.
 Singh DP, Aacharya RP (2006) Pattern of poisoning cases in Bir Hospital. Journal of Institute of Medicine 28(1):3-6.
 Kishore PV, Palaian S, Paudel R, Mishra D, Ojha P, Alam K, et al (2008) Pattern of poisoning cases in a teaching hospital in Western Nepal. Journal of Institute of Medicine30 (1):26-34.
 AHujA H, mAtHAi AS, PAnnu A, ArorA r (2015) Acute Poisonings Admitted to a Tertiary Level Intensive Care Unit in Northern India: Patient Profile and Outcomes. Journal of Clinical and Diagnostic Research9 (10).
 S B, P P, D S, NK B, AK D, GS S, et al (2009) Clinical profile and outcome of children presenting with poisoning or intoxication: a hospital based study. Nepal Med Coll J11 (3):170-5.
 Pillay V (2008) Current Views on Antidotal Therapy in Managing Cases of Poisoning and Overdose. JAPI 56.
 Albertson TE, Owen KP, Sutter ME, Chan AL (2011) Gastrointestinal decontamination in the acutely poisoned patient. International Journal of Emergency Medicine4 (65).http://dx.doi.org/10.1186/1865-1380-4-65.
 Harish D, Chavali KH, Singh A, Kumar A (2011) Recent Advances in the Management of Poisoning Cases. J Indian Acad Forensic Med33 (1).
 Greene SL, Dargan PI, Jones AL (2005) Acute poisoning: understanding 90% of cases in a nutshell. Postgrad Med J 81:204-16.http://dx.doi.org/10.1136/pgmj.2004.024794.
 Hanssens o, Deleu D, Y AT (2001) Etiologic and Demographic Characteristics of Poisoning: A Prospective Hospital-Based Study in Oman Clinical Toxicology39 (4):371-80.