Dimethylnitrosamine (DMN) pre-treated rats and protective effect of Vernonia amygdalina post-treatment on liver function

  • Authors

    • Usunomena Usunobun benson idahosa university, benin city, edo state, nigeria
    • Gabriel Anyanwu 2Department of Biochemistry, Bingham University, Karu, Nasarawa State, Nigeria.
    2016-05-03
    https://doi.org/10.14419/ijpt.v4i1.6065
  • Dimethylnitrosamine, Pre-treatment, Post-treatment, Vernonia amygdalina.

  • Abstract

    Background: Liver disease and toxicity is common, especially with many drug treatments. The effect of Vernonia amygdalina ethanolic leaf extract post-treatment on rats pre-treated with dimethylnitrosamine (DMN) was evaluated.

    Methods: Male wistar rats were orally administered DMN (single dose of 25 mg/kg) on first day and thereafter post-treated with 100 and 200mg/kg ethanolic leaf extract of Vernonia amygdalina for seven days. Analysis of serum concentrations of albumin, total protein, total bilirubin and glucose were carried out.

    Results: Administration of DMN alone to rats significantly increased glucose and total bilirubin concentration (P < 0.05) in the serum while it significantly reduced (P<0.05) serum total protein and albumin concentrations when compared with controls. However, post-treatment of DMN administered rats with 100 and 200 mg/kg ethanolic extract leaf of Vernonia amygdalina significantly (P<0.05) reversed these changes in a concentration dependent manner.

    Conclusion: In conclusion ethanolic leaf extract of Vernonia amygdalina have a potent hypoglycaemic and hepatoprotective action against dimethylnitrosamine-induced liver damage in rats may be due to its antioxidant properties.

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  • How to Cite

    Usunobun, U., & Anyanwu, G. (2016). Dimethylnitrosamine (DMN) pre-treated rats and protective effect of Vernonia amygdalina post-treatment on liver function. International Journal of Pharmacology and Toxicology, 4(1), 74-77. https://doi.org/10.14419/ijpt.v4i1.6065

    Received date: 2016-04-01

    Accepted date: 2016-04-27

    Published date: 2016-05-03