Pharmacological evaluation of oxazine sulfonamide derivatives for anti-inflammatory, analgesic and antipyretic activities

  • Authors

    • Shailaja Ande Jawaharlal Nehru Technological university, Hyderabad.
    • khadar Shaik Jawaharlal Nehru Technological university, Hyderabad.
    • Ravi Dharmoji Jawaharlal Nehru Technological university, Hyderabad.
    • Nisa Firdouse Jawaharlal Nehru Technological university, Hyderabad.
    • Anjum Mohd Jawaharlal Nehru Technological university, Hyderabad.
    • Sowmya Yelwarthi Jawaharlal Nehru Technological university, Hyderabad.
    2016-06-08
    https://doi.org/10.14419/ijpt.v4i2.6123
  • Analgesic, Ant-Pyretic, Anti-Inflammatory, Oxazine Sulphonamide Derivatives, Yeast, Carrageenan, Plethysmometer.
  • Oxazine heterocyclic compound containing one oxygen and one nitrogen atom. They possess different pharmacological activities like anticancer, anti-ulcer, antifungal, antithrombotic, antihypertensive, analgesic, anti-inflammatory etc. Oxazine Sulphonamide derivatives were investigated for anti-inflammatory, analgesic and anti-pyretic activities. It was evaluated for anti-inflammatory activity by carrageenan induced paw edema in rats using Plethysmometer and it also shows significant analgesic effect in male Albino mice. Antipyretic activity was also investigated.

  • References

    1. [1] Albert.Meyers, AikoNabeya, H.WayneAdickes, J. MichealFitzpatrick, G. Ray Malone, and leve R. Politzerpp 1969, Aldehydes from dihydro-1,3-oxazines. II. Synthesis of. Alpha.Beta. -Unsaturated aldehyde and their C-1 deuterated derivatives, J. Am.Chem. Soc 764-767.

      [2] Basudeb, A; Sukhendu, M.;Dutta, P.K.; Chowdhury,C. 2004. Synette, 14, 2449.

      [3] BencsicsS, Elenkov IJ, Vizi EJ. 1995. Alpha 2-, alpha 2A-, alpha 2B/2C-adrenoceptor subtype antagonist prevent lipopolysaccharide-induced fever response in rabbits. Brain Res; 705:302-306.http://dx.doi.org/10.1016/0006-8993(95)01154-4.

      [4] B lettes, E.;Lockhart, B.; Lestage, P.; Schwendimann, L.; Gressens,P.; Fleury,, M-B.; Largeron, M.2005 J. Med. Chem. 48,1282.

      [5] Breder CD, Dinarello CA, Saper CB.1988, Interleukin-1 immunoreactive innervations of the human hypothalamus. Science; 240:321-324.http://dx.doi.org/10.1126/science.3258444.

      [6] Buckman, B.O; Mohan, R.; KOovakkat,DS.1998, Bioorg. Med. Chem. Lett.,8, 2235.http://dx.doi.org/10.1016/S0960-894X(98)00386-2.

      [7] Burke W.J.Am. Chem.Soc 1954;76;1677.http://dx.doi.org/10.1021/ja01635a065.

      [8] C.A Winter, E. Risley, and G. Nuss, “Carrageenan-induced edema in hind aw of the rat as an assay for imflmmatory drugs,†Proceedings of the societyfor Experimental Biology and Medicine, vol.111, pp.544-547,1962.http://dx.doi.org/10.3181/00379727-111-27849.

      [9] Chiu, H. I.; Lin C.; Cheng, C. Y.; Tsai, M. C.; Yu, H.C. 2001 Bioorg. Med. Chem. Lett., 9, 383.http://dx.doi.org/10.1016/S0968-0896(00)00260-1.

      [10] Chiistie, R.M., Agyako, C.K., Mitchel, 1995 Dyes pigments, 29, 241.http://dx.doi.org/10.1016/0143-7208(95)00049-L.

      [11] David,M., Aroff, M.D., Eric, G., Neilson, M.D.,2001. Antipyretics: Mechanism of Action and Clinical Use in Fever Supression.

      [12] I. Posadas, M. Bucci, F. Roviezzo et al., “Carrageenan-induced mouse paw oedema is biphasic, age-weight fependant and displays differential nitric oxide cuclooxygenase-2 expression,†British journal of pharmacology, vol. 142, no. 2, pp. 331-338, 2004

      [13] Jahnke K, thiel E, Bechrakis NE,2008 “ Ifosamide or trofosfamide on patients with intraocular lymphomaâ€. J. Neurooncol.93 (2): 213-217.http://dx.doi.org/10.1007/s11060-008-9761-8.

      [14] Kajino, N.; Shibouta; Nishikawa, K.; Meguro, K. 1991 Chem. Pharm. Bull. 11 2896.http://dx.doi.org/10.1248/cpb.39.2896.

      [15] Katsure, Y.; Nishino, S., Takasugi, H. 1991 Chem. Pharm. Bull. 11, 293.

      [16] Li S, Ballou LR, Morham SG.2001 Cyclooxygenase-2 mediates the febrile response of mice to interleukin-1 beta. Brain Res; 910:163-173.http://dx.doi.org/10.1016/S0006-8993(01)02707-X.

      [17] Li S, Sehic E, Wang Y. 1999 Relationship between complement andthe febrile response of guinea pigs to systemic Endotoxin. Am J Physiol; 277:1635-1645A.

      [18] M. Harsh, Inflammation and Healing, Jaypee publication, 2002.

      [19] Nair, M.G.; Saltor, O. C.; Kisliuk, R. L.; Gaumont, Y. 1983, J. Med Chem. 26 1164. http://dx.doi.org/10.1021/jm00362a015.

      [20] Organic synthesis, Coll Vol. 6, p.905 (1988): Vol. 51, p.24 (1971).

      [21] Rawlins, M., 1973. Mechanism of salicylate –induced antpyresis. S Karger AG, 311.

      [22] ShaliniDalal, MD, and Donna S. Zhukovsky, MD, FACP2006. Pathophysiology of Fever.

      [23] Sharma Sakshy, Hullatti KK. Sachin Kumar, Tiwari KR. Brijesh. Comparative antioxidant activity of Cuscutareflexa and Cassythafiliformis. Journal of Pharmacy Research 2012; 5(1), 441-443.

      [24] Sheth UK, Dadkar NK, Kamath NG. Selected topics inexperimentalpharmacology. Vol 5, Kothari Book Depot,Bombay, India, 1972, 63.

      [25] Shilpkar P. an alternate use of calotropisgigantea: biomethanation. Current science 2007, 92(4); 435-437.

      [26] Tripathi KD. Essentials of Medical Pharmacology. 5th Ed. New Delhi: Jaypee Brothers Medical Publishers; 2003.

      [27] Warrier, P.K., V.P.K Nambiar, and C. Mankutty 1994. Indian Medicinal Plants. Oriet Longman; Chennai, India p. 341â€345.

      [28] Vizi ES. 1988, Receptor- mediated local fine-tuning by noradrenergic innervations of neuroendocrine and immune systems. Ann N Y AcadSci; 851: 388-396.http://dx.doi.org/10.1111/j.1749-6632.1998.tb09012.x.

      [29] Watikins LR, Maier SF, Goehler LE. 1995, Cytokine-to-brain communication: a review and analysis of alternative mechanisms. Life Science;57:1011-1026http://dx.doi.org/10.1016/0024-3205(95)02047-M.

      [30] Zhou, D. H.; Berger, J.; Clerk, D,; Sethofer, S.G.; Krauss, N. e,;Brothers, J. M.; Martin, TR. S.; Misner, D. L.; Schwabd, D,; Alexandrovad, L.2007, Bioorg. Med. ChemLett. 17, 3504.http://dx.doi.org/10.1016/j.bmcl.2006.12.093.

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    Ande, S., Shaik, khadar, Dharmoji, R., Firdouse, N., Mohd, A., & Yelwarthi, S. (2016). Pharmacological evaluation of oxazine sulfonamide derivatives for anti-inflammatory, analgesic and antipyretic activities. International Journal of Pharmacology and Toxicology, 4(2), 111-114. https://doi.org/10.14419/ijpt.v4i2.6123