Tissue distribution of sulphadimidine sodium in non-starved and starved grower turkeys (meleagris gallopavo)

 
 
 
  • Abstract
  • Keywords
  • References
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  • Abstract


    Background: The use of veterinary drugs in food-producing animals has potential to generate residues in edible tissues and posses health hazard to consumers especially when the withdrawal period is not observed.

    Objectives: The study was conducted to determine the tissue residue and withdrawal period of sulphadimidine in non-starved and starved grower turkeys following a single intramuscular administration.

    Methods: Forty two turkeys of both sexes and 12 weeks old weighing 1.57±0.2 kg were divided into two groups of twenty one each. One group was administered a single intramuscular dose of sulphadimidine sodium (100mg/kg body weight). The other group was kept off-feed for 48 hours before drug administration. Three turkeys each were sacrificed from the starved and non-starved group and two grammes (2g) of tissue sample were harvested from selected tissues.

    Results: The results showed that the drug residues persisted in all the tissues of turkeys sampled for up to thirty (30) days after drug administration. The starved turkeys maintained consistently higher concentrations of the drug in the tissues than fed ones. Sulphadimidine residue was significantly increased (p<0.05) between days 3 to 6 in the spleen of non-starved turkeys. However, the concentrations in the spleen decreased significantly (p<0.05) between days 6 to 10 and 25 to 30.

    Conclusion: Sulphadimidine residue persisted in the tissues of non-starved and starved turkeys for up to 30 days after intramuscular injection. This should be given due consideration in the estimation of the withdrawal period for the drug, since sulphadimidine residue in meat > 0.2 ppm is unsafe for human consumption.


  • Keywords


    Maximum Residue Limit; Sulphadimidine; Grower Turkeys; Hypersensitivity.

  • References


      [1] Baggot JD (2001) the Physiological Basis of Veterinary Clinical Pharmacology, Blackwell Science, Oxford.

      [2] Bevill RF, Sharma RM, Meachum SH, Bourne, D.W & Dittert, L.W (1977). Disposition of sulphonamides in food-producing animals: concentrations of sulfamethazine and its metabolites in plasma, urine, and tissues of lambs following intravenous administration. American Journal of Veterinary Research, 38(7):973-977.

      [3] Bratton AC & Marshal EK (1939). A new coupling component for sulphonamide determination. Journal of Biology and Chemistry, 128: 537-550.

      [4] Caloin M (2004). Modeling of lipid and protein depletion during total starvation. American Journal of Physiology, 287: E790–E798. http://dx.doi.org/10.1152/ajpendo.00414.2003.

      [5] Carriciolo, EA, Toop E & Grenni P (2015). Pharmaceuticals in the environment: Biodegradation and effects on natural microbial communities. A review. Journal of Pharmaceutical and Biomedical Analysis, 106(1): 25-36.

      [6] CIOMS (2012). http://www.cioms.ch/index.php/12-newsflash/326-cioms-and-iclas-release-the-new-international-guiding-principles-for-biomedical-research-involving-animals. Accessed 12th May, 2016.

      [7] Codex Alimentarius (1996). Bulletin of Ministry of Agriculture of the Slovak Republic, XXVII: part 14: 271-295.

      [8] Council Regulation (1990). Community Procedure for the establishment of maximum residue limits of veterinary medicinal products in food stuffs of animal origin. Official Journal of European Communities. 224: 1-8.

      [9] Duffee NE, Bevill RF, Thurmon JC, Luther HG, Nielsen DE & Hacker FE (1984). Pharmacokinetics of sulphadimidine in male, female and castrated male swine. Journal Veterinary Pharmacology and Therapeutics, 7: 203-211. http://dx.doi.org/10.1111/j.1365-2885.1984.tb00901.x.

      [10] Etuk EU, Umarudeen AM, Onyeyili PA & Elsa TA (2006). Effect of short term starvation on the plasma kinetics of sulphadimidine in rabbits. International Journal of Pharmacology, 2(3): 331-334. http://dx.doi.org/10.3923/ijp.2006.331.334.

      [11] FAO/WHO (1992). A second meeting of the joint FAO/WHO expert committee on food additives. Code of Federal Regulations 21: 365.

      [12] Garcia-Galan, M.J, Diaz-cruz, M.S & Barcelo, D (2008). Identification and determination of metabolites and degradation products of sulphonamide antibiotics. Trends in Analytical Chemistry 27: 1008-1022. http://dx.doi.org/10.1016/j.trac.2008.10.001.

      [13] Geertsma MF, Nouws JFM, Grondel JL, Aerts ML, Vree TB & Kan CA. (1987). Residues of sulphadimidine and its metabolites in eggs following oral sulphadimidine medication of hens. Veterinary Quarterly, 1:67-75. http://dx.doi.org/10.1080/01652176.1987.9694077.

      [14] Gravetter FJ & Wallnau LB. (2004). Statistics for the Behavioural Sciences, 6th ed, Thomson Wadsworth Belmonth USA.

      [15] Gutierrez IR, Watanabe N, Harter T, Glaser, B & Radke M. (2010). Effect of sulphonamide antibiotics on microbial diversity and activity in a Californian Mollic Haploxeralf. Journal of Soils Sediment 10: 537-544. http://dx.doi.org/10.1007/s11368-009-0168-8.

      [16] Heath GE, Kline DA, Bamess CJ & Showalter DH (1975) Elimination of sulphamethazine from edible tissues, blood, urine and feces of turkey poults. American Journal of Veterinary Research, 36: 913-197.

      [17] Hervant F & Renault D (2002). Long-term fasting and realimentation in hypogean and epigean isopods: a proposed adaptive strategy for groundwater organisms. Journal of Experimental Biology, 205: 2079–2087.

      [18] Kan CA & Petz M. Residues of veterinary drugs in eggs and their distribution between yolk and white. Journal of Agricultural and Food Chemistry, 48: 6397-6403. http://dx.doi.org/10.1021/jf000145p.

      [19] Kennedy DG, Cannavan A & Mccracken RJ (2000). Regulatory problems caused by contamination, a frequently overlooked cause of veterinary drug residues. Journal of Chromatography A, 882: 37-52. http://dx.doi.org/10.1016/S0021-9673(00)00320-4.

      [20] Liu F, Ting GG, Tao R, Zhao JI, Yang JF & Zhao LF (2009). Effects of six selected antibiotics on plant growth and soil microbial and enzymatic activities. Environmental pollution 157: 1636-1642. http://dx.doi.org/10.1016/j.envpol.2008.12.021.

      [21] Lüders H, Lai KW, Hinz KH (1974). Blood and tissue content of sulfamethazine and sulfaquinoxaline in broilers following medication with drinking water. A combination to mass medication in poultry. Zentralbl. Vetmed. B, 21, 110-118. http://dx.doi.org/10.1111/j.1439-0450.1974.tb00472.x.

      [22] Nouws JFM, Geertsma MF, Grondel JL, Aerts MML, Vree TB & Kan CA (1988). Plasma disposition and renal clearance of sulphadimidine and its metabolites in laying hens. Research in Veterinary Science, 44: 202-207.

      [23] NRAAVCA (2000). Sulfonamides review Final Report, publication archive. 2000: 1-42.

      [24] Olasehinde EF, Hassan N, Adenuga OS, Hiraki K & Sakugaw, H. (2013). Hydroxy radical mediated degradation of diuron in river water. Journal of American Science 9:29-34.

      [25] Onyeyili PA, Egwu GO, Apampa OA, Ameh J (1997). Elimination of sulphadimidine from edible tissues and blood of guinea fowl, domestic chickens and ducks, Bulletin of African Animal Health and Production, 45:225-229.

      [26] Onyeyili PA, Ogundele OO & Sanni S (2000). Effect of starvation on the elimination kinetics of sulphadimidine in Broiler chickens. Nigerian Journal of Experimental and Applied Biology, 1: 25-28.

      [27] Righter HF, Worthington JM & Mercer, H.D (1971). Tissue-residue depletion of Sulfamethazine in calves and chickens. American Journal Veterinary Research, 32(7): 1003-1006.

      [28] Salinas F, Mansilla E & Nevado JJB (1990). Derivative spectrophotometric determination of sulphonamides by Bratton-Marshall reaction. Analytica Chemica Acta, 233:289-294. http://dx.doi.org/10.1016/S0003-2670(00)83490-X.

      [29] Sandhu HS & Rampal S (2006). Essentials of Veterinary Pharmacology and Therapeutics, Kalyani publishers, New Delhi, India.

      [30] Shoaf SE, Schwark WS & Guard CL (1987). The effect of age and diet on sulfadizine/trimethoprim disposition following oral and subcutaneous administration to calves. Journal of Veterinary Pharmacology Therapeutics, 10(4): 331-345. http://dx.doi.org/10.1111/j.1365-2885.1987.tb00110.x.

      [31] Wang T, Hung CCY & Randall DJ (2006). The comparative physiology of food deprivation: from feast to famine. Annual Review of Physiology, 68: 223–251. http://dx.doi.org/10.1146/annurev.physiol.68.040104.105739.

      [32] Watanabe N, Bergamaschi BA, Laftin KA, Meyer MT & Hartner T. Use and environmental occurrence of antibiotics in free stall dairy farms with manure forage fields. Environmental Science and Technology, 44:6591-6600. http://dx.doi.org/10.1021/es100834s.

      [33] Weiss C, Conte, A, Milandri, C, Scortichini, G, Semprini, P, Usberti, R & Migliorati, G. (2007). Veterinary drugs residue monitoring in Italian poultry: Current strategies and possible developments. Food Control, 18: 1068-1076. http://dx.doi.org/10.1016/j.foodcont.2006.07.011.


 

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Article ID: 6513
 
DOI: 10.14419/ijpt.v4i2.6513




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