Comparative parasitological and electron microscopic studies on the effects of Nitazoxanide and Praziquantel in Schistosoma mansoni-infected mice

  • Authors

    • Hend A. El-Taweel Department of Medical Parasitology, Medical Research Institute, Alexandria University, Alexandria, Egypt.
    • Mona H. El-Sayad
    • Sahar A. Abu Helw
    • Mohammad A. Al-Kazzaz
    2016-11-26
    https://doi.org/10.14419/ijpt.v4i2.6822
  • Antischistosomal, Electronmicroscopy, Nitazoxanide, Parasitological, Praziquantel, Schistosoma.

  • Abstract

    This study was designed to evaluate antischistosomal activity of Nitazoxanide (NTZ) in Schistosoma mansoni-infected mice compared to Praziquantel (PZQ). Fifty four infected mice were recruited into 3 groups, each of 18 mice. Group 1 was infected non-treated control. Group 2 was infected and then treated with PZQ 500 mg for two days, and group 3 was infected and treated with NTZ 100 mg/kg for seven days. Efficacy of drugs was assessed by Parasitological, and scanning electron microscopic studies. PZQ reduced (4.9%, 22.5% and 50.7%) of faecal eggs, (22%, 22.6% and 55.1%) of intestinal eggs, (20.4%, 44.3% and 46.7%) of hepatic egg counts and (27%, 45.1% and 64.9%) of total worm load whereas, NTZ reduced (4.9%, 22.5% and 50.7%),of faecal eggs, (22%, 22.6% and 55.1%) of intestinal eggs ,(20.4%, 44.3% and 46.7%) of hepatic egg counts and (27%, 45.1% and 64.9%) of total worm load at 1, 2 and 4 WPT, respectively. The percentages of dead eggs were more than 80% after PZQ treatment and only 30% after NTZ at 4 WPT. PZQ showed extensive tegumental damages in male and female worms more than NTZ at 2 WPT. Our findings concluded that Nitazoxanide showed weaker antischistosomal activity in animal models than praziquantel.

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    A. El-Taweel, H., H. El-Sayad, M., A. Abu Helw, S., & A. Al-Kazzaz, M. (2016). Comparative parasitological and electron microscopic studies on the effects of Nitazoxanide and Praziquantel in Schistosoma mansoni-infected mice. International Journal of Pharmacology and Toxicology, 4(2), 228-234. https://doi.org/10.14419/ijpt.v4i2.6822

    Received date: 2016-10-03

    Accepted date: 2016-11-17

    Published date: 2016-11-26