Antibacterial activity of Saponaria officinalis and Zanthoxylum aramatum

  • Authors

    • Veda G Andhra University
    • Mallikarjuna Rao T Andhra University
    • Ganga Rao B Andhra University
    2016-12-07
    https://doi.org/10.14419/ijpt.v5i1.6898
  • Saponaria Officinalis, Zanthophyllum Aramatum, Roots and Antimicrobial Activity.

  • Abstract

    The present study was carried out to evaluate the antimicrobial properties of two traditional medicinal plant species Saponaria officinalis and Zanthophyllum aramatum belonging to the families Raryophyllaceae and Rutaceae. The root part was selected for the antibacterial activity, and extracts were prepared using soxhlet extraction procedure using different solvents successively. Different extracts of selected plants tested their anti-microbialproperty using agar well diffusion method at different concentration on standard human pathogenic bacterial strains. The selected plants extracts concentrated dependent bactericidal activity on tested standard bacterial strains. The zones of inhibitions were measured for each concentration of various extracts on each bacterial strain tested in a millimeter (mm). All concentrations of extracts showed minimum zone of inhibition (8mm). The chloroform extracts at 5mg/100µL showed less activity. But, as the concentration increases the bactericidal activity was increased. The extracts showed more activity at 40mg/100µL. Among two plants S. officinalis showed more antibacterial activity. In these, methanol extracts of two plants more competent results along with ciprofloxacin on tested bacterial strains. The extracts also showed more activity on gram-negativeorganisms compared to gram-positiveorganisms. The extracts showed more activity on E. coli and S. typhimurium and lower activity on C. sporogenes and S. pneumoniae. The results of the present study provide the evidence on antibacterial property of selected medicinal plants and there is a scope to further studies on isolation of antimicrobial compounds from these species.

  • References

    1. [1] Aminov RI. (2009). the role of antibiotics and antibiotic resistance in nature. Environ Microbiol, 11: 2970–2988.https://doi.org/10.1111/j.1462-2920.2009.01972.x.

      [2] AminovRustam I. (2010). A Brief History of the Antibiotic Era: Lessons Learned and Challenges for the Future. Front Microbiol, 1: 134.https://doi.org/10.3389/fmicb.2010.00134.

      [3] C. Lee Ventola, MS. (2015). The Antibiotic Resistance Crisis- Part 1: Causes and Threats. P T. 40(4): 277–283.

      [4] Claudio Gualerzi O, Brandi Letizia, FabbrettiAttilio, Pon Cynthia L (2013). Antibiotics: Targets, Mechanisms and Resistance. John Wiley & Sons. p1.

      [5] Eliopoulos GM. (2004). Current and new antimicrobial agents. Am Heart J, 147(4): 587-92.https://doi.org/10.1016/j.ahj.2003.06.006.

      [6] Ganga Rao, B. T. MallikarjunaRao, Y VenkateswaraRao. (2012). Anti-Bacterial Activity of Different extracts of Melochiacorchorifoliaand Spilanthesacmella aerial parts. Journal of Pharmacy Research (2012); 5 (6): 3022-3024.

      [7] Gootz TD. (1990). Discovery and development of new antimicrobial agents. ClinMicrobiol Rev. 3(1): 13–31.https://doi.org/10.1128/CMR.3.1.13.

      [8] Gootz, TD, Barrett, JF, Sutcliffe, JA. (1990). Inhibitory effects of quinolone antibacterial agents on eucaryotic topoisomerases and related test systems. Antimicrob. Agents Chemother, 34: 8–12.https://doi.org/10.1128/AAC.34.1.8.

      [9] Habich D, Von Nussbaum F. (2006). Platensimycin, a new antibiotic and “superbug challenger†from nature. Chem Med Chem, 1: 951–954.https://doi.org/10.1002/cmdc.200600145.

      [10] JaswantRai, GurpreetKaurRandhawa, and MandeepKaur. (2013). Recent advances in antibacterial drugs. Int J Appl Basic Med Res, 3(1): 3–10.https://doi.org/10.4103/2229-516X.112229.

      [11] JatinSrivastava, Harish Chandra, Anant R Nautiyal, Swinder JS Kalra. (2014). Antimicrobial resistance (AMR) and plant-derived antimicrobials (PDAms) as an alternative drug line to control infections. 3 Biotech. 4(5): 451–460.

      [12] Khare CP. 2007. Indian Medicinal Plants: An Illustrated Dictionary. Springer. ISBN: 978-0-387-70637.

      [13] Negi JS, Bisht VK, Bhandari AK, Singh P, Sundriyal RC. (2011). Chemical Constituents and Biological Activities of the Genus Zanthoxylum: A Review. African Journal of Pure and Applied Chemistry, 5(12): 412-416.

      [14] Phillips I. (1983). Environmental factors contributing to antibiotic resistance. Infect Control, 4 (6):448-51.https://doi.org/10.1017/S0195941700058446.

      [15] Rajbhandari KR. 2001. Ethanobotany of Nepal, Ethano botanical Society olf Nepal, Khatmmandu. P. 189.

      [16] Schelz Z, Hohmann J, Molnar J. (2010). Recent advances in research of antimicrobial effects of essential oils and plant derived compounds on bacteria. Ethnomedicine: A Source of Complementary Therapeutics, 179–201.

      [17] Singh TP & Singh OM. (2011). Phytochemical and Phar-macological Profile of Zanthoxylumarmatum DC.—An Overview. Indian Journal of Natural Products and Resources, 2(3): 275-285.

      [18] Stuart B. Levy. (2002). Factors impacting on the problem of antibiotic resistance. J AntimicrobChemother, 49 (1): 25-30.https://doi.org/10.1093/jac/49.1.25.

      [19] Sum PE & Petersen P. (1999). Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936. Bioorg Med ChemLett, 17; 9(10):1459–1462.

      [20] Tan SY &Tatsumura Y (2015). Alexander Fleming (1881-1955): Discoverer of penicillin. Singapore Medical Journal, 56(7): 366-367. https://doi.org/10.11622/smedj.2015105.

      [21] Wolff D, Witt T, Jurgens A, Gottsberger G. (2006). Nectar dynamics and reproductive success in Saponaria officinalis (Caryophyllaceae) in southern Germany. Flora. Morphologie, Geobotanik, Oekophysiologie. 201 (5): 353–364.

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  • How to Cite

    G, V., T, M. R., & B, G. R. (2016). Antibacterial activity of Saponaria officinalis and Zanthoxylum aramatum. International Journal of Pharmacology and Toxicology, 5(1), 1-4. https://doi.org/10.14419/ijpt.v5i1.6898

    Received date: 2016-10-23

    Accepted date: 2016-11-27

    Published date: 2016-12-07