Myocardial ischemia: narrative drug targets and management by ethnobotanicals

  • Authors

    • Amna batool Phd scholor,department of pharmacy,Govt college University ,Faislabad Sargodha
    • Umme hasan Phd scholor , FACULTY OF PHARMACY UNIVRSITY OF SARGODHA-PAKISTAN Phd Scholor,UNIVRSITY OF SARGODHA-PAKISTAN
    • Farah abid Phd scholor,FACULTY OF PHARMACEUTICAL SCIENCES, GOVT COLLEGE UNIVERSITY FAISLABAD-PAKISTAN
    • Ambreen Utra Phd scholor,FACULTY OF PHARMACY UNIVRSITY OF SARGODHA-PAKISTAN
    • Umer maqsood Phd scholor,FACULTY OF PHARMACY UNIVRSITY OF SARGODHA-PAKISTAN
    • Bushra Shaukat Phd scholor,FACULTY OF PHARMACEUTICAL SCIENCES, GOVT COLLEGE UNIVERSITY FAISLABAD-PAKISTAN
    2017-02-09
    https://doi.org/10.14419/ijpt.v5i1.7098
  • Cardiac Ischemia, Atherosclerosis, Treatment Protocol, Novel Drug Targets.

  • Abstract

    Cardiac ischemia is characterized by imbalance between oxygen demand and its supply to myocardium owing to atherosclerotic plaques, which results in moderate to severe damage to heart function. Ischemic heart disease leads to cardiac arrhythmia and heart failure. Various therapeutic interventions, including lifestyle modification, pharmacological treatment options and surgical procedures are available. Besides these therapies, ischemic patients have to suffer from cardiac events repeatedly. Therefore, novel treatment modalities directed towards LDL cholesterol synthesis, oxidation of LDL, monocyte/macrophage recruitment, foam cells, platelet aggregation, cytokines and extracellular matrix comprising of smooth muscle cells have been found to be the promising targeted therapies. Moreover, drugs of ethnobotanical origin might be safer, effectual and economic, thus improving the quality of life.

  • References

    1. [1] Bhatti IP, Lohano HD, Pirzado ZA, & Jafri IA (2006) A logistic regression analysis of the Ischemic Heart Disease Risk. Journal of Applied Sciences 6, 785-788. https://doi.org/10.3923/jas.2006.785.788.

      [2] Barman NR, Nandy S, Datta R, & Kar PK (2013) Cardioprotective effect of ethanolic extract of Urtica parviflora Roxb. Against isoproterenol induced myocardial infarction in rats. Indian journal of pharmacology 45, 513-516. https://doi.org/10.4103/0253-7613.117782.

      [3] Beaulah A, Mohamed SA & Sivakumar V (2014) Cardioprotective activity of methanolic extract of Croton sparciflorus on isoproterenol induced myocardial infarcted wistar albino rats. Journal of Medicinal Plants 2, 01-08.

      [4] Calvez V, Ebde A, Meunier N, & Raoult A (2009) Mathematical modelling of the atherosclerotic plaque formation. In ESAIM: Proceedings 28, 1-12. https://doi.org/10.1051/proc/2009036.

      [5] Chhabria MT & Brahmkshatriya PS (2006) Novel targets for the treatment of atherosclerosis. Current Opinion in Investigational Drugs 7, 820-825.

      [6] Erdmann E. (2009). Safety and tolerability of beta-blockers: prejudices and reality. European Heart Journal 11, A21–A25 doi:10.1093/eurheartj/sup001

      [7] Gibbons RJ, Abrams J, Chatterjee K, Daley J, Deedwania PC, Douglas JS & O'Rourke RA (2003) ACC/AHA 2002 guideline update for the management of patients with chronic stable angina. Journal of the American College of Cardiology 41, 159-168. https://doi.org/10.1016/S0735-1097(02)02848-6.

      [8] Gauthaman KK, Saleem MT, Thanislas PT, Prabhu VV, Krishnamoorthy KK, Devaraj NS & Somasundaram JS (2006) Cardioprotective effect of the Hibiscus rosa sinensis flowers in an oxidative stress model of myocardial ischemic reperfusion injury in rat. BMC Complementary and Alternative Medicine 6, 1-8. https://doi.org/10.1186/1472-6882-6-32.

      [9] Gomathi R, Vijipriya M, & Usha K (2014) Cardio protective effect of ethanolic extract of Medicago sativa stem on isoproterenol induced myocardial infarction in Wistar Albino rats. International Journal of Pharmacy and Pharmaceutical Sciences 6, 839-842.

      [10] He H, Xu J, Xu Y, Zhang C, Wang H, He Y & Yuan D (2012) Cardioprotective effects of saponins from Panax japonicus on acute myocardial ischemia against oxidative stress-triggered damage and cardiac cell death in rats. Journal of ethnopharmacology 140, 73-82. https://doi.org/10.1016/j.jep.2011.12.024.

      [11] Karthikeyan K, Bai BS, Gauthaman K, Sathish KS, & Devaraj SN (2003) Cardioprotective effect of the alcoholic extract of Terminalia arjuna bark in an in vivo model of myocardial ischemic reperfusion injury. Life sciences 73, 2727-2739. https://doi.org/10.1016/S0024-3205(03)00671-4.

      [12] Kurian GA, Suryanarayanan S, Raman A, & Padikkala J (2010) Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts. Chinese medicine 5, 2-7 https://doi.org/10.1186/1749-8546-5-3.

      [13] Libby P & Theroux P (2005) Pathophysiology of coronary artery disease. Circulation 111, 3481-3488. https://doi.org/10.1161/CIRCULATIONAHA.105.537878.

      [14] Levchenko TS, Hartner WC, Verma DD, Bernstein EA & Torchilin VP (2010) ATP-loaded liposomes for targeted treatment in models of myocardial ischemia. Liposomes: Methods and Protocols, Pharmaceutical Nanocarriers 1, 361-375. https://doi.org/10.1007/978-1-60327-360-2_25.

      [15] Mohanty I, Arya DS, Dinda A, Joshi S, Talwar KK & Gupta SK (2004) Protective effects of Curcuma longa on ischemia-reperfusion induced myocardial injuries and their mechanisms. Life sciences 75, 1701-1711. https://doi.org/10.1016/j.lfs.2004.02.032.

      [16] Murray CJ & Lopez AD (1996) Evidence-based health policy--lessons from the Global Burden of Disease Study. Science 274, 740-743. https://doi.org/10.1126/science.274.5288.740.

      [17] Ojha SK, Bharti S, Joshi S, Kumari S & Arya DS (2012) Protective effect of hydroalcoholic extract of Andrographis paniculata on ischaemia-reperfusion induced myocardial injury in rats. The Indian journal of medical research 135, 414-421.

      [18] Pragada RR, Veeravalli KK, Chowdary KPR & Routhu KV (2004) Cardioprotective activity of Hydrocotyle asiatica L. in ischemia-reperfusion induced myocardial infarction in rats. Journal of ethnopharmacology93,105-108. https://doi.org/10.1016/j.jep.2004.03.025.

      [19] Prince P & Rajadurai M (2005) Preventive effect of Aegle marmelos leaf extract on isoprenalineâ€induced myocardial infarction in rats: biochemical evidence. Journal of pharmacy and pharmacology 57, 1353-1357. https://doi.org/10.1211/jpp.57.10.0015.

      [20] Rajak S, Banerjee SK, Sood S, Dinda AK, Gupta YK, Gupta SK & Maulik SK (2004) Emblica ofï¬cinalis causes myocardial adaptation and protects against oxidative stress in ischemicâ€reperfusion injury in rats. Phytotherapy Research 18, 54-60. https://doi.org/10.1002/ptr.1367.

      [21] Ramachandra Y, Ashajyothi C & Padmalatha R (2012) Cardio protective effect of aegle marmelos on isoproterenol induced myocardial infarction in rats. International journal of Biology, Pharmnacy and Applied sciences 1, 718-729

      [22] Ramadoss S, Kannan K, Balamurugan K, Jeganathan NS & Manavalan R (2012) "Efficacy of Cardioprotective Effects in Ethanolic Extract of Sida Rhombifolia Linn. On Isoproterenol-Induced Myocardial Infarction in Albino Rats. Research Journal of Pharmaceutical, Biological and Chemical Sciences 3, 488-493.

      [23] Rao PR, Kumar VK, Viswanath RK & Subbaraju GV (2005) Cardioprotective activity of alcoholic extract of Tinospora cordifolia in ischemia-reperfusion induced myocardial infarction in rats. Biological and Pharmaceutical Bulletin 28, 2319-2322. https://doi.org/10.1248/bpb.28.2319.

      [24] Shen JG & Zhou DY (1995) Efficiency of Ginkgo biloba extract (EGb 761) in antioxidant protection against myocardial ischemia and reperfusion injury. Biochemistry and molecular biology international 35, 125-134

      [25] Pepine CJ & Nichols WW (2007) the pathophysiology of chronic ischemic heart disease. Clinical cardiology 30, I-4. https://doi.org/10.1002/clc.20048.

      [26] Saini HK, Xu YJ, Arneja AS, Tappia PS & Dhalla NS (2005) Pharmacological basis of different targets for the treatment of atherosclerosis. Journal of cellular and molecular medicine 9, 818-839. https://doi.org/10.1111/j.1582-4934.2005.tb00382.x.

      [27] Singhal A & Lucas A (2004) early origins of cardiovascular disease: is there a unifying hypothesis? The Lancet 363, 1642-1645. https://doi.org/10.1016/S0140-6736(04)16210-7.

      [28] Tomkin GH & Owens D (2012) LDL as a cause of atherosclerosis. The Open Atherosclerosis & Thrombosis Journal 5, 13-21 https://doi.org/10.2174/1876506801205010013.

      [29] Sudhakumari A, Javed A, Jaiswal M & Talkad MS (2012) Cardioprotective Effects in Methanolic Extract of Evolvulus Alsinoides Linn on Isoproterenol-Induced Myocardial Infarction in Albino Rats. International Journal of Basic Medical Sciences and Pharmacy (IJBMSP) 2, 53-57.

      [30] Thippeswamy BS, Thakker SP, Tubachi S, Kalyani GA, Netra MK, Patil U & Veerapur VP. (2009). Cardioprotective effect of Cucumis trigonus Roxb on isoproterenol-induced myocardial infarction in rat. American journal of pharmacology and toxicology 4, 29-37. https://doi.org/10.3844/ajptsp.2009.29.37.

      [31] Velavan S, Selvarani S & Adhithan a (2009) Cardioprotective effect of Trichopus zeylanicus against myocardial ischemia induced by isoproterenol in rats. Bangladesh Journal of Pharmacology 4, 88-91. https://doi.org/10.3329/bjp.v4i2.1824.

      [32] Wilson HM, Barker RN & Erwig LP (2009) Macrophages: promising targets for the treatment of atherosclerosis. Current vascular pharmacology 7, 234-243. https://doi.org/10.2174/157016109787455635.

      [33] Yusuf S, Reddy S, Ôunpuu S & Anand S (2001) Global burden of cardiovascular diseases part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation 104, 2746-2753. https://doi.org/10.1161/hc4601.099487.

      [34] Yagi A, Fujimoto K, Tanonaka K, Hirai K & Takeo S (1989) Possible aktive components of Tan-Shen (Salvia miltiorrhiza) for protection of the myocardium against ischemia-induced derangements. Planta medica 55, 51-54. https://doi.org/10.1055/s-2006-961824.

      [35] Yamashiro S, Noguchi K, Matsuzaki T, Miyagi K, Nakasone J, Sakanashi M & Aniya Y (2003) Cardioprotective effects of extracts from Psidium guajava L. and Limonium wrightii, Okinawan medicinal plants, against ischemia-reperfusion injury in perfused rat hearts. Pharmacology 67, 128-135. https://doi.org/10.1159/000067799.

      [36] Zhao BL, Jiang W, Zhao Y, Hou JW & Xin WJ (1996) Scavenging effects of salvia miltiorrhiza on free radicals and its protection for myocardial mitochondrial membranes from ischemia-reperfusion injury. Biochemistry and molecular biology international 38, 1171-1182.

      [37] Zhou JY, Fan Y, Kong JL, Wu DZ & Hu ZB (2000) Effects of components isolated from Astragalus membranaceus Bunge on cardiac function injured by myocardial ischemia reperfusion in rats]. Zhongguo Zhong yao za zhi= Zhongguo zhongyao zazhi= China journal of Chinese materia medica 25, 300-302.

      [38] Ziaee M, Khorrami A, Ebrahimi M, Nourafcan H, Amiraslanzadeh M, Rameshrad M & Garjani A (2015) Cardioprotective effects of essential oil of Lavandula angustifolia on isoproterenol-induced acute myocardial infarction in rat. Iranian journal of pharmaceutical research: IJPR 14, 279-289.

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  • How to Cite

    batool, A., hasan, U., abid, F., Utra, A., maqsood, U., & Shaukat, B. (2017). Myocardial ischemia: narrative drug targets and management by ethnobotanicals. International Journal of Pharmacology and Toxicology, 5(1), 23-30. https://doi.org/10.14419/ijpt.v5i1.7098

    Received date: 2016-12-13

    Accepted date: 2017-01-11

    Published date: 2017-02-09