Bioavailability, pharmacokinetics and tissue residues of cephradine (Atocef Forte®) in healthy and colisepticemic broiler chickens

  • Authors

    • Mohamed Aboubakr professor of pharmacology
    • Mohamed Elbadawy professor of pharmacology
  • Pharmacokinetics, Tissue Residues, Cephradine, Chickens, Bioavailability.
  • The pharmacokinetics (after single intravenous and oral dose) and tissue residues (orally and daily for five days) of cephradine (20 mg/kg b.wt.) were investigated in healthy and experimentally E.coli infected broiler chickens. Following single intravenous injection to healthy chickens, cephradine obeyed a two compartments open model and the elimination half-life (t1/2β), volume of distribution (Vdss) and total body clearance (CLtot) of cephradine were 2.93 h, 321.5 ml/kg and 0.08 L/h/kg, respectively. Following single oral administration of cephradine to healthy chickens, the peak serum concentration (Cmax) of it was 26.7 µg/mL and achieved (Tmax) at 2.41 h. The oral bioavailability of cephradine was 87.7%. Cephradine was assayed in kidney, liver, heart, gizzard, spleen, breast muscle, thigh muscle and skin after 24, 48, 72, 96 and 120 h after last dose. On conclusion, cephradine is a good choice for treatment of colisepticemia in chickens due to its higher oral bioavailability and distribution.

  • References

    1. [1] Aboubakr M (2016) Bioavailability and pharmacokinetics of cefotaxime in Muscovy ducks. International Journal of Pharmacology and Toxicology. 4 (1), 93-95.

      [2] Arret B., Johnson D.P., Kirshbaum A. (1971) Outline of details for microbiological assay of antibiotics: Second revision. Journal of Pharmaceutical Science. 60(11):1689-1694.

      [3] Baggot J.D. (1978 b) some aspects of clinical pharmacokinetics in veterinary medicine II. Journal of Veterinary Pharmacology and Therapeutics. II: 111-118.

      [4] Baggot J.D. (1978 a) some aspects of clinical pharmacokinetics in veterinary medicine I. Journal of Veterinary Pharmacology and Therapeutics. I: 5-18.

      [5] Dumka V.K.; Dinakaran V.; Ranjan B. and Rampal S. (2013) Comparative pharmacokinetics of cefquinome following intravenous and intramuscular administration in goats. Small Ruminant Research. 113(1): 237-277.

      [6] El - Gendy A.A.M., Tohamy M.A., Ismail M. (2007) Comparative pharmacokinetic and renal clearance study of ceftiofur in cross breed Freisian and buffalo calves. Beni-Suef Veterinary Medical Journal. 17(1): 69-77.

      [7] El -Sayed M.G., Atef M., El-Komy A.A. (1994) Disposition kinetics of cephradine in normal and Escherichia coli infected goats .DtschTierarztlWochenschr. 101 (2): 56-60.

      [8] EL-Sayed M, Aboubakr M, Rabea S. (2016) Pharmacokinetics and tissue residues of cephradine in healthy and experimentally Salmonella entretidis infected broiler chickens. World Journal of Pharmacy and Pharmaceutical Sciences. 6(6): 61-74.

      [9] Foord RD. (1969) Cephalexin-bacteriology, pharmacology and toxicology. Proceedings of a symposium on the clinical evaluation of cephalexin. Royal Society of Medicine London, PP 3.

      [10] Griffeth RS. (1983) the pharmacology of cephalexin. Postgard Med. J. 59: 16-27.

      [11] Griffith RS. and Black H. R. (1970) Cephradine Med. Clin. North America. 54: 1229.

      [12] Henry M.M., Morris D.D., Lakritz J., Aucoin D. (1992) Pharmacokinetics of cephradine in neonatal foals after single oral dosing. Equine Veterinary Journal. 24(3): 242-243.

      [13] Kumar S. Srivastava A.K., Dumka V.K., Kumar N, Raina R.K. (2010) Plasma pharmacokinetics and milk levels of ceftriaxone following single intravenous administration in healthy and endometritic cows. Vet. Res. Commun. 34(6): 503-510.

      [14] Martindale, the extra pharmacopoeia, by James E F. Renolds, Royal. Pharmaceutical Society, London. 30th Edition; 1993.

      [15] Rattie E.S., Bernardo P.D., Ravin L.J. (1976) Pharmacokinetic interpretation of cephradine levels in serum after intravenous and extravascular administration in humans. Antimicrobial Agents and Chemotherapy. 10(2): 283-287.

      [16] Rebuelto M., Albarellos G., Ambros L.; Kreil V., Montoya L., BonafineR.,Otero P. , Hallu R. (2002) Pharmacokinetics of ceftriaxone administered by intravenous, intramuscular or subcutaneous routes to dogs. J.Vet. Pharmacol. and Therap. 25 (1): 73-76.

      [17] Ritchel W.A. (1973) Angewandtebiophomazie, wissenschoftlicheverlaggesellschoft.mbtt, Stuttgart. Pp.533.

      [18] Roberts D.H., Kandall M.J., Jack D.B., Welling P.G. (1981) Pharmacokinetics of cephradine given intravenously with and without probencid. Br. J. Clin. Pharmac. 11: 561-564.

      [19] Shalaby, M.A., Goudah A., Gihan M. Kamel, Hassan A. Shaheen . (2014) Disposition kinetics of cefquinome in healthy rabbits following intramuscular and oral administration.World journal of pharmacy and pharmaceutical sciences. 4(1): 263-274.

      [20] Shen J, Wu X, Hu D and Jiang H (2002). Pharmacokinetics of florfenicol in healthy and Escherichia coli-infected broiler chickens. Research in Veterinary Science, 73(2): 137-140.

      [21] Snedecor G.W., Cokran W.G. (1980) Statistical methods. 7th Ed. Iowa State University Press. Ames. Iowa, U.S.A, pp; 39-63.

      [22] Tohamy M.A. (2008) Pharmacokinetic of ceftiofur sodium administered concomitantly with dipyrone in healthy and feverish cows. Journal of Egypt Society of Pharmacology and Experimental Therapeutics. 29(2): 539-550.

      [23] Weliky I., Gadebusch H.H., Kripalani K., Arnow P., Schreiber C. (1974) Cephradine : Absorption, Excretion, and Tissue distribution in animals of a new cephalosporin antibiotic. Antimicrobial Agents and Chemotherapy. 5(1): 49-54.

      [24] Wise R. (1990) the pharmacokinetics of oral cephalosporins. A review. Journal of Antimicrobial Chemotherapy. 26: 13-20.

      [25] Xie W., Zhang X., Wang T., Du S. (2013) Pharmacokinetic analysis of cefquinome in healthy chickens Br. Poult. Sci. 54(1): 81-86.

      [26] Yuan L. ,Sun J. , Wang R. , Sun L. , Zhu L. , Luo X. , Fang B. , Liu Y. (2011) Pharmacokinetics and bioavailability of cefquinome in healthy ducks. American Journal of Veterinary Research, 72 (1): 122-126.

  • Downloads

  • How to Cite

    Aboubakr, M., & Elbadawy, M. (2017). Bioavailability, pharmacokinetics and tissue residues of cephradine (Atocef Forte®) in healthy and colisepticemic broiler chickens. International Journal of Pharmacology and Toxicology, 5(1), 57-60.