Pharmacokinetics of thiamphenicol in normal and pasteurella multocida infected lactating goats

  • Authors

    • Mossad Elsayed Professor of Pharmacology Deprtment, Faculty of Veterinary Medicine, Benha University
    • Ashraf Elkomy Professor of Pharmacology Deprtment, Faculty of Veterinary Medicine, Benha University
    • Faten Ibrahim Assitant Lecturer of Pharmacology Deprtment, Faculty of Veterinary Medicine, Benha University
  • Pharmacokinetics, Thiamphenicol, Pasteurella multocida, Lactating Goats.
  • The pharmacokinetic parameters of thiamphenicol following intravenous and intramuscular (single & repeated) administrations were estimated in normal and experimentally pasteurella multocida infected goats. Following a single intravenous injection of 30 mg thiamphenicol /kg b.wt. in normal goats, thiamphenicol could be detected therapeutically for 24 hours post intravenous injection. The serum concentration – time curve of thiamphenicol following intravenous injection showed that the drug obeyed a two compartments open model. The intramuscular bioavailability of thiamphenicol in normal goats was 66.63 %. Intramuscular injection of 30 mg thiamphenicol per kilogram body weight once daily for five consecutive days in normal and pastreulla multocida infected goats revealed a lower significant serum thiamphenicol concentration in pastreulla multocida infected goats compared with normal goats, also it’s found that: marked significant decrease in ( k1, K12, K21, T0.5(α) , T0.5(β), Tmax and CLtot in normal compared with infected goats, on the other hand a significant increase in Cmax,AUC, C0,B and β in normal compared with infected goats. Thiamphenicol was cleared by all clearance processes (Cltot) in the body at significant faster rates in Pasteurella multocida infected goats than in normal goats. The concentrations of thiamphenicol in milk were significantly lower in Pasteurella multocida infected goats than in normal goats. The mean peak urine concentrations of thiamphenicol were reached 4 hours after each intramuscular dose with a lower significant concentration in Pasteurella multocida infected goats than in normal goats.

  • References

    1. [1] Abd-El-Aty. A.M.; Goudah, A.; Abo, E. S. K; El Zorba H.Y;Shimoda .M and Zhou H.H ( 2004): Pharmacokinetics and bioavailability of florfenicol following intravenous, intramuscular, and oral adminsteration in rabbit. Vet Res Commun. 28: 515-524.

      [2] Abdennebi E.H; Sawchuk RJ and Stowe C.M.(1994 b): Thiamphenicol pharmacokinetics in beef and dairy cattle. J Vet Pharmacol Ther. 17(5):365-368.

      [3] Abdennebi.E.H, Stowe.C.M (1994): Pharmacokinetics and distribution of thiamphenicol in sheep given repeated intramuscular doses. Vet. Res. 25,489-494.

      [4] Abdulgafar. O;Jimoh; Shaibu.o . B; Emmanuel U. E; SolomonA.A and Vincent U. I. (2011): Comparative Pharmacokinetics of intramuscular ceftriaxone Co- administered with acetaminophen in healthy and infected sokoto Red goats. Inter. J. Pharmacol 7 (5): 623-628.

      [5] Aldana.I, Fos .D, Gonzalez B, Gazzaniga A, CeppiM, Figini PG, Zato.MA, Bruseghini.L, and Esteras A.( 1992): Oculer pharmacokinetics of thiamphenicol in rabbit Arzenimittelforschung 42 (10) 1236-1239.

      [6] Ali B.H; Al-Qarawi A.A and Hashaad M. (2003): Comparative plasma pharmacokinetics and tolerance of florfenicol following intramuscular and intravenous administration to camels, sheep and goats Vet Res Commun. 27(6):475-483.

      [7] Al-Nazawi, M.H. (2005): Pharmacokinetics and tolerance of thiamphenicol in camels and sheep. Inter.J. Pharmacol. 1 (1) 25-28.

      [8] Arret,B;Hohnson,D.P and kirshbaum,A(1971) : Outline of details for microbiological assay of antibiotics : second revision J. Pharm .Sci. 60 (11) 1689-1694.

      [9] Atef .M; El-Gendi A.Y; Aziza M.M and Abd El-Aty A.M (2000): Pharmacokinetic properties of florfenicol in Egyptian goats. Dtsch Tierarztl Wochenschr. Apr;107(4):147-150.

      [10] Baggot, J.D. (1977): Priniciple of pharmacokinetics .In principle of drug disposition in domestic animals. The physiological Basis of veterinary Clinical Pharmacology, 1st ed.WB Saunders Co. Philadelphi, PA. 168-179.

      [11] Baggot, J.D (1978a) some aspect of clinical pharmacokinetics in veterinary medicine I J.Vet.Pharm.Ther. 1: 5-18

      [12] Baggot, J.D (1978b) some aspect of clinical pharmacokinetics in veterinary medicine II. J.Vet.Pharm.Ther. 1: 111-118.

      [13] Baggot .J.D. (1980): Distribution of antimicrobial agents in normal and diseased animals. J.A.V.M.A. 19 (76): 1085-1090.

      [14] Bennett .J.V; Brodie, J.L; Benner, E and Kibry, W (1966): Simplified accurate method for antibiotic assay for clinical specimen. Appl. Microbial 14: 170-175.

      [15] Bogzil,A.H and Tohamy, M.A (2015) Pharmacokinetics and bioavailability of Thiamphenicol glycinate HCl in male goats. IJDDHR 5(1):849-854.

      [16] Birdane Y.o and Birdane F.M (2015): Pharmacokinetics of florfenicol following intravenous and intramuscular adminsteration in dogs. Veterinaria Medicina 60(6): 323-329.

      [17] Castells G, Capece .B, Pérez B, Martì G, Arboix M, Cristòfol C. (2001): Allometric analysis of thiamphenicol disposition among seven mammalian species J Vet Pharmacol Ther. 24(3) 193-197.

      [18] El-Banna H.A and El-Zorba H.Y (2011) Pharmacokinetics of florfenicol (Water soluble formulation) in healthy and Pasteurella infected broiler chickens. World Rural Observ 3(1):13-19.

      [19] El-Sayed, M.G.; Atef, M. and El-Komy, A.A. (1994): Disposition kinetic of cephradine in normal and Escherichia coli infected goats. Dtsch.Tierarztl. Wochenschr. 101(2): 56-60.

      [20] El-Sayed. M.G.; Hatem. M.E. and El-Komy, A.A. (1989): Disposition kinetic of gentamicin in normal and endometric cow using microbiological assay. Dtsch.Tierarztl. Wochenschr. 96(8): 412-415.

      [21] Etuk. E.U and Onyeyili P.A. (2006): The effect of Salmonella infection on the plasma kinetic of chloramphenicol in the sokoto red goats. Inter. J. Pharmacol. 2(1): 28-32.

      [22] Gilman, A.G.; Goodman. L.S. and Ghman, A, (1980): Goodman and Gilman’s: The pharmacological basis of therapeutics, 6th ed. (New York, MacMillian), pp. 21.

      [23] Grove .D.C and Randall W.A (1955): Assay methods of antibiotics. Medical encyclopedia ,New York79 (12) 259-32

      [24] Haddad, N. S.; Pedersoli, W. M.; Ravis, W. R.; Fazeli, M. H. and Carson Jr, R. L. (1985): Pharmacokinetics of gentamicin at steady-state in ponies: serum, urine, and endometrial concentrations. Am. J. Vet. Res. 46(6): 1268-1271.â€

      [25] Intorre L;Mengozzi,.G; Bertini. S; Fabbrini. M;Soldani. G and Secchiari. P (1997): Pharmacokinetics of thiamphenicol in the preruminant calf. Atti della Societa vol 51:249-250.

      [26] Jianzhong.S; Fung .K.F; Chen .Z; Zeng. Z and Zhang .J (2003): Pharmacokinetics of florfenicol in healthy pigs and in pigs experimentally infected with Actinobaccilus pleuropneumoniae. Antimicrob. Ag .chemother. 47(2) 820-823.

      [27] Jianzhong.S; Xiubo.L; Haiyang.J and Walter.H.H (2004): Bioavailability and pharmacokinetics of florfenicol in healthy sheep. J Vet Pharmacol Ther 27(3): 163–168.

      [28] Jianzhong.S, Zeng. Z, Chen .Z, Liu JJ, and Fung .K.F (2006): Pharmacokinetics of florfenicol in pigs following intravenous, intramuscular or oral adminsteration and the effects of feed intake on oral dosing J .Vet. Pharmacol Ther 29,153-156.

      [29] Li. S,Maxwell, R.J. and Shadwell, RJ,( 2002): Solubility of amphenicol bacteriostats in CO2. Fluid Phase Equilibria 198:67–80.

      [30] Lohani M; Ahmad A.H; Singh K.p and Sheetal V (2010): Pharmacokinetics and residual studies of florfenicol following multiple dose oral administration in Poultry. J. Appl. Anim. Res. 38: 9-12.

      [31] Lobell R.D; Varma K.J; Johnson J.C; Sams R.A; Gerken D.F and Ashcraft S.M (1994): Pharmacokinetics of florfenicol following intravenous and intramuscular doses to cattle. J. Vet. Pharmacol. Ther. Aug; 17 (4): 253-258.

      [32] Mengozzi G; Intorre L; Bertini S; Giorgi M; Secchiari PLand Soldani G (2002): A comparative kinetic study of thiamphenicol in pre-ruminant lambs and calves. Res Vet Sci. 2002 Dec;73(3):291-295.

      [33] Mestorino .N; Landoni M.F; Alt M and Errecalde J.O (1993): The pharmacokinetics of thiamphenicol in lactating cows. Vet Res Commun 17(4):295-303.

      [34] Mestorino O.N, Errecalde J.O. (1998): Chloramphenicol pharmacokinetics after intravenous and intramuscular administration in sheep Zentralbl Veterinarmed A;45(3):175-180.

      [35] Murray. R (1984): Creatinin .kaplane etal .Clinc Chem Ther .C.V Mosby Co .S Louis.Toronto.Princeton1261-1266 and 418. Zentralbl Veterinarmed A;45(3):175-180.

      [36] Perez R; PalmaC; Drapela C; Espinosa. A and Penaillo A.K (2015): Pharmacokinetics of florfenicol after intravenous admnisteration in Escherichia coli lipopolysaccharide induces endotoxaemic sheep. J Vet Pharmacol Ther.38 (2) 144-149.

      [37] Sanders P;Guillot P and Mourot D ( 1988): Pharmacokinetics of a long-acting chloramphenicol formulation administered by intramuscular and subcutaneous routes in cattle. J Vet Pharmacol Ther Jun; 11 (2):183-190.

      [38] Snedecor, G.W and Cokran, W.G (1980): Statistical method 7th Ed. TheIowastate university press,Ames,Iowa,USA39-63.

      [39] Tohamy M.A and Radi A.M (2008): Bioavailability and pharmacokinetics of florfenicol in healthy foals J. Egypt. Soc. Pharmacol. Exp. Ther 29(.2) 529-537.

      [40] Turton, J.A., Havard, A.C., Robinson, S.; Holt, D.E.; Andrews, C.M.; Fagg, R. and Williams, T.C, 2000: Anassessment of chloramphenicol and thiamphenicol in the induction of aplastic anaemia in the BALB/c mouse. Food Chem Toxicol 38:925–938.

      [41] Turton, J.A.; Andrews, C.M.; Havard, A.C.; Robinson, S.; York, M.; Williams, T.C. and Gibson, F.M, (2002): Haemotoxicity of thiamphenicol in the BALB/c mouse and Wistar Hanoverrat. Food Chem Toxicol 40:1849–1861.

      [42] Tullio, V.; Cuffini, A.; Mandras, N.; Roana, J.; Banche, G.;Ungheri, D. and Carlone N (2004) : Influence of thiamphenicol on the primary functions of human polymorphonuclear leucocytes against Streptococcus pyogenes. Int J Antimicrob Agents 24:381–385.

      [43] Verma, S;Ahmad, A.H; Rahal, Aand Singh, K.P (2009): Pharmacokinetics of florfenicol following single dose intravenous and intramuscular administration in goats. Appl. Anim. Res., 36: 93–96.

      [44] Wesongah.J.O; Murilla.G.O; Guantai.A.N and Mdachi.R.E (2009): Pharmacokinetics of Chloramphenicol in Sheep after intramuscular adminsteration. East and Central African Journal of Pharmaceutical Sciences Vol. 12 :3-7

      [45] Yang B; Yang L;Jianheng Z;Jing Z;Jiake H; Di Zhao; Pengfei S, andXijing C (2011): Pharmacokinetics of the prodrug thiamphenicol glycinate and its active parent compound thiamphenicol in beagle dogs following intravenous administration. Xenobiotica, 2011; 41(3): 226–231.

      [46] Zamir .S.M, and Shafarin .M.S. (2007): Response of goats to the different routes of infection by Pasteurella multocida B: 2. J. Animal .vet. Advance. 6(3):340-343.

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    Elsayed, M., Elkomy, A., & Ibrahim, F. (2017). Pharmacokinetics of thiamphenicol in normal and pasteurella multocida infected lactating goats. International Journal of Pharmacology and Toxicology, 5(2), 61-71.