Anti-inflammatory potentials, membrane stabilizing and xanthine oxidase inhibitory activities of Clerodendrum volibule ethanolic leaf extract on carragenaan- induced inflammation in rats

  • Authors

    • Olarenwaju Olufunmilayo. Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife,
    • OLOGE Mary Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin.
    • Oyemitan Idris Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife,
    • AKOMOLAFE Rufus Department of Physiological Sciences, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife,
    • Akinpelu Bola Department of Biochemistry, Faculty of Sciences, Obafemi Awolowo University, Ile-Ife,
    • Apata Joseph Department of Biochemistry, Faculty of Sciences, Obafemi Awolowo University, Ile-Ife,
    • IWALEWA EZEKIEL OLUGBENGA Dept of Pharmacology and Therapeutics, College of Medicine University of Ibadan, Nigeria
    2018-01-16
    https://doi.org/10.14419/ijpt.v6i1.8410
  • Antiinflammatory, Clerodendrum volibule, lipoxygenase, rats, xanthine oxidase.

  • The folkloric use of Clerodendrum volubile P Beauv (Verbenaceae) for treatment of inflammatory conditions in the Southern part of Nigeria has been reported. The anti-inflammatory action of the ethanolic leaf extract on carrageenan-induced rat paw oedema, lipoxygenase and xanthine oxidase inhibitory effects, and membrane stabilizing potential were evaluated. The extract reduced carrageenan-induced rat paw oedema in a dose dependent manner compared to control group. C. volubile inhibited xanthine oxidase activity in a dose - dependent manner; at 0.5 mg/ml it exhibited maximum inhibitory activity of 95.48% while the standard drug, allopurinol exhibited 70 % inhibition. The extract significantly inhibited lipoxygenase activity, with highest activity at 0.4 mg/ml while Quercetin showed maximum inhibition of the enzyme at 0.1 mg/ml. The extract and Acetaminophen exhibited maximum membrane stabilizing activity of 91.85 ± 0.50% and 94.32 ± 0.32% at 2.5 mg/ml respectively. These findings provide justification for the traditional use of C. volubile in inflammatory conditions.

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    Olufunmilayo., O., Mary, O., Idris, O., Rufus, A., Bola, A., Joseph, A., & EZEKIEL OLUGBENGA, I. (2018). Anti-inflammatory potentials, membrane stabilizing and xanthine oxidase inhibitory activities of Clerodendrum volibule ethanolic leaf extract on carragenaan- induced inflammation in rats. International Journal of Pharmacology and Toxicology, 6(1), 7-11. https://doi.org/10.14419/ijpt.v6i1.8410