Determination of serum cadmium and lead in healthy adults from the west of Algeria

  • Abstract
  • Keywords
  • References
  • PDF
  • Abstract

    Cadmium and lead are ubiquitous and non-biodegradable pollutants representing a great concern to human health. They share common environmental exposure routes through contaminated food, water, and soil. This study was conducted to determine the serum cadmium and lead levels in healthy adults. In the present work, differential pulse anodic stripping voltammetry (DPASV) using a hanging mercury drop electrode (HMDE) was used in order to determine the trace level of cadmium and lead ions in real samples.A populations of one hundred and fifteen healthy adults with a mean concentration of 0.67 ± 0.31 µg.L-1 and 53.11 ± 3.25 µg.L-1 for cadmium and lead were determined, respectively. The accuracy and precision were in agreement with the certified values for both metals by using certified reference materials. Mean serum lead and cadmiumin the current study indicates that in general the population studied here is not exposed to worrisome Pb and Cd levels.


  • Keywords

    Serum; Cadmium; Lead; Healthy Adults; DPASV.

  • References

      [1] Monisha J, Tenzin T, Naresh A, Blessy BM, Krishnamurthy NB. (2014) Toxicity, mechanism and health effects of some heavy metals. InterdiscipToxicol 7, 60–72.

      [2] Cho S, Kim YL, Kim SR, Cho DK, Kim YJ, Kang SK. (2001) Cadmium intoxication and its effects on kidney function. Korean J Nephrol 20, 1004–1013

      [3] Holdaway J, Wuyi Wang. (2018) From Soil Pollution to “Cadmium Rice” to Public Health Impacts: An Interdisciplinary Analysis of Influencing Factors and Possible Responses. J. Resour. Ecol 9, 10-21.

      [4] Jenna EF, Saiful Islam M, Masud SP, Raqib R, Sajjadur RM. (2018) Prevalence of elevated blood lead levels among pregnant women and sources of lead exposure in rural Bangladesh: A case control study. Environmental Research 166, 1-9.

      [5] Lennart H, Lars J, Bodil P, Olav A. (2004) Using environmental concentrations of cadmium and lead to assess human exposure and dose. Journal of Exposure Science & Environmental Epidemiology 14, 416–423.

      [6] Wu X, Liang Y, Jin T, Ye T, Kong Q, Wang Z, et al. (2008) Renal effects evolution in a Chinese population after reduction of cadmium exposure in rice. Environ Res 108, 233–238.

      [7] Yabe J, Nakayama SMM, Ikenaka Y, Yohannes YB, Bortey-Sam N, Kabalo AN, et al (2018) Lead and cadmium excretion in feces and urine of children from polluted townships near a lead-zinc mine in Kabwe, Zambia. Chemosphere 202, 48-55.

      [8] Fariborz S, Abasalt B (2016) Lead exposure and neurodegenerative diseases. Der Pharmacia Lettre 8; 14-18.

      [9] Lidsky TI, Schneider JS (2003) Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain 126, 5-19.

      [10] Garza A, Vega R, Soto E (2006) Cellular mechanisms of lead neurotoxicity. J. Exp. Clin. Res 12, 57-65

      [11] Eshraghi A, Imen S, Vojdanparast M, Khameneh Bagheri R, Jalalyazdi M. (2017) Correlation between Serum Lead Level and Coronary Slow Flow Phenomenon. Patient Saf Qual Improv 5, 471-474.

      [12] Chen X, Zhou H, Li X, Wang Z, Zhu G, Jin T (2015) Effects of lead and cadmium co-exposure on hemoglobin in a Chinese population. Environ Toxicol Pharmacol 39,758-763.

      [13] Nasiruddin MR, Jitbanjong T, Masudur R (2018) Toxicodynamics of Lead, Cadmium, Mercury and Arsenic- induced kidney toxicity and treatment strategy: A mini review. Toxicology Reports 5, 704-713.

      [14] Kim NH, Hyun YY, Lee KB, Chang Y, Ryu S, Oh KH, Ahn C (2015) Environmental heavy metal exposure and chronic kidney disease in the general population. J Korean Med Sci 30, 272-277.

      [15] Lee MS, Park SK, Hu H, Lee S (2011) Cadmium exposure and cardiovascular disease in the 2005 Korea National Health and Nutrition Examination Survey. Environ Res 111, 171-176.

      [16] Srivastava RK, Pandey P, Rajpoot R, Rani A, Dubey RS (2014) Cadmium and lead interactive effects on oxidative stress and antioxidative responses in rice seedlings. Protoplasma 251, 1047-1065.

      [17] Mohammed AA, Mohd NMH, Abd Wahid H, Mohd YMS, Mohd AR (2016) The detrimental effects of lead on human and animal health. Vet World. 9, 660–71.

      [18] Jung KS, Kim NS, Ahn SC, Lee BK (2012) Relationship between urine cadmium and bone mineral density of residents around abandoned metal mines. Korean J Environ Health Sci 38, 323–31.

      [19] Andjelkovic M, Djordjevic AB, Antonijevic E (2019) Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney. Int J Environ Res Public Health 16, 274-294.

      [20] Checconi P, Sgarbanti R, Celestino I, Limongi D, Amatore D, Iuvara A, et al (2013) The environmental pollutant cadmium promotes influenza virus replication in MDCK cells by altering their redox state. Int J Mol Sci 14, 4148–62.

      [21] Hambach R, Lison D, D'Haese PC, Weyler J, De Graef E, De Schryver A, et al (2013) Co-exposure to lead increases the renal response to low levels of cadmium in metallurgy workers. Toxicol Lett 222, 233–38.

      [22] Kim Y, Ha EH, Park H, Ha M, Kim Y, Hong YC, et al (2013) Prenatal lead and cadmium co-exposure and infant neurodevelopment at 6 months of age: the Mothers and Children's Environmental Health [MOCEH] study. Neurotoxicology 35, 15–22.

      [23] Attar T, Harek Y, Larabi L (2013) Determination of Zinc levels in Healthy Adults from the West of Algeria by Differential Pulse Anodic Stripping Voltammetry. Journal of advances in chemistry 6, 855-60.

      [24] Attar T, Harek Y, Larabi L (2012) Dosage du cadmium et du plomb dans le sang humain par voltamètrie à redissolution anodique. Ann Biol Clin 70, 595-8. DOI : 10.1684/abc.2012.0738

      [25] Attar T, Harek Y, Larabi L (2013) Determination of Ultra Trace Levels of Copper in Whole Blood by Adsorptive Stripping Voltammetry. Journal of the Korean Chemical Society 57, 568-73.

  • The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader).

    If you would like more information about how to print, save, and work with PDFs, Highwire Press provides a helpful Frequently Asked Questions about PDFs.

    Alternatively, you can download the PDF file directly to your computer, from where it can be opened using a PDF reader. To download the PDF, click the Download link above.




Article ID: 29769
DOI: 10.14419/jes.v1i2.29769

Copyright © 2012-2015 Science Publishing Corporation Inc. All rights reserved.