Overuse of antibiotics in high-income, middle -income, and low-income countries: patients' knowledge, attitude, behaviour, and factors affecting doctor’s prescription behaviour and attitude of prohibiting antibiotics prescription. A Systematic Review.

Authors

  • Dr. Sabita Shaha 43 High Street, Heathfield, TN21 8HU, UK

DOI:

https://doi.org/10.14419/jsc.v3i1.31232

Keywords:

Resistance, Antibiotics, Attitude, Knowledge

Abstract

Background: The excessive use of antibiotics have currently been recorded as a common phenomenon globally, and it has important public health repercussion. Consuming antibiotics every time an individual is suffering from a normal viral infection would make resistant to the antibiotics. And not be able to cure the disease, leading to harmful side effect for endorsing antibiotic resistance. The current study will be complementing all existing literature by systemic review of the available evidence on public knowledge, attitude, and behaviour regarding the misuse of antibiotics in the high, middle and low-income countries. This study also aims to investigate factors affecting physician's prescription behaviour and factors prohibiting the prescription of antibiotics. Methods: A systematic review performed through pub med, and EBSCO-HOST scientific database January 2010 to March 2020 was considered including a cross-sectional study and focus group discussion. And investigating knowledge, attitude, behaviour about antibiotic use and factors prohibiting doctor's prescription behaviour. Result: All the studies included in this review had definite objectives regarding patient, knowledge, attitude and behaviour associated with antibiotics use. These study had applied proper methodology for cross-sectional summary related to the search question. Most of the (22) reviews had appropriate methodology associated with a representative of the population. Six studies had not clear sample size and did not represent the entire population. Twenty studies had tested the validity and reliability test. A general question used by this survey categorised into four main themes. Theme: 1. Knowledge and awareness of antibiotic use, 2: attitude and behaviour related to antibiotic use, 3: knowledge and awareness of AMR and 4: factors affecting physicians prescription behaviour and attitude of prohibiting antibiotics. Conclusion: To maximise the use of surveys, the application in findings in survey and associated factors related to antibiotic use and AMR should primarily create public health intervention. A multifaceted approach is likely to improve more successful. The studies provide sufficient evidence which proves that a targeted approach in interventions has been successful in reducing antibiotic prescription and misuse.

References

Porco et al. (2012). 'When Does Overuse of Antibiotics Become a Tragedy of the Commons?' Plos One, 7(12), e46505. https://doi.org/10.1371/journal.pone.0046505. 14 SPC Journal of Social Sciences [2] 2 Leekha S, Terrell CL, Edson RS. General principles of antimicrobial therapy Mayo Clin Proc, 2011; 86(2):156-67. doi: 10.4065/mcp.2010.0636 Available at https://www.health.qld.gov.au/news-events/news/antibiotics-viruses-cold-flu. (Accessed: March 30 2020). https://doi.org/10.4065/mcp.2010.0639. [3] 3 US Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States, 2013. April 2013. https://www.cdc.gov/drugresistance/threat-report-2013/pdf/ar-threaths-2013-508.pdf (Accessed March 05 2020) [4] 4 Available at https://www.health.qld.gov.au/news-events/news/antibiotics-viruses-cold-flu. (Accessed: March 30 2020) [5] 5 Chaw P, Hopner J and Mikolajczyk R. (2018) ’The Knowledge, attitude and practice of health practitioners towards antibiotic prescribing and resistance in developing countries-A systematic review’, Wileyonlinelibrary.com,(43),606. https://doi.org/10.1111/jcpt.12730. [6] 6 Pereira JQ, Silva MT & Galvão TF. (2018). 'Use of antibiotics by adults: a population-based cross-sectional study'. Sao Paulo Medical Journal, 136(5), 407-413. https://doi.org/10.1590/1516-3180.2018.0168060818. [7] 7 Sukkar, E. (2013). ‘Why are there so few antibiotics in the research and development pipeline?’ The Pharmaceutical Journal, 291, 520. [8] 8 Harwood, C. ‘The rise of antibiotic resistance’ I-Sense. Available at: https://www.i-sense.org.uk/infectious-diseases/bacterial-infections/rise-antibiotic-resistance (Accessed: March 30 2020). [9] 9 O’Neill, J. The review on antimicrobial resistance: tackling drug-resistant infections globally: final report and recommendations. (2016). https://amrreview.org/sites/default/files/160518_Final%20paper_with%20cover.pdf. [10] 10 HM Government (2016). Review on antimicrobial resistance: Tackling drug-resistant infections globally. London. https://amrreview.org/sites/default/files/160525_Final%20paper_with%20cover.pdf. https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/477962/ESPAUR_Report_2015.pdf. [11] 11 Available at https://www.cidrap.umn.edu/news-perspective/2018/03/price-pay-antibiotic-resistant-infections-cost-2-billion-year (Accessed March 15 2020) [12] 12 Boseley, S. (2015) ‘Rising antibiotic resistance increasing risks of routine surgery-study’, The Guardian (UK), October 16. Available at: https://www.theguardian.com/society/2015/oct/16/antibiotic-resistance-routine-surgery-impossible-study (Accessed:30 March 2020) [13] 13 Centers for Disease Control and Prevention. Antibiotic Use in the United States, 2017: Progress and Opportunities. Atlanta, GA: US Department of Health and Human Services, CDC; 2017. Available at: https://www.cdc.gov/antibiotic-use/stewardship-report/pdf/stewardship-report.pdf [14] 14 ECDC/EMEA. Technical Report. The bacterial challenge: time to react.Sep2009.https://www.ecdc.europa.eu/sites/default/files/media/en/publications/0909 TER The Bacterial Challenge Time to React.pdf (Accessed March 05, 2020) [15] 15 US Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States, 2013. April 2013. https://www.cdc.gov/drugresistance/threat-report-2013/pdf/ar-threaths-2013-508.pdf (Accessed March 05, 2020) [16] 16 Alumran A et al., 'Antibiotic overuse in Children with Upper Respiratory tract infections in Saudi Arabia: risk factors and potential interventions' (2011) Scientific & Academic Publishing; 1(1):8-16 https://doi.org/10.5923/j.cmd.20110101.02. [17] 17 MD Rezal RS, Hassali MA, Alrasheedy AA, Saleem F, Md Yusof FA, Godman B. Physicians' knowledge, perceptions and behaviour to-wards antibiotic prescribing: a systematic review of the literature. Expert Rev Anti Infect Ther.2015:13(5):665-680. https://doi.org/10.1586/14787210.2015.1025057. [18] 18 Coxeter P, Del Mar CB, McGregor L, Beller EM, Hoffmann TC. Interventions to facilitate shared decision making to address antibiotic use for acute respiratory infections in primary care. Cochrane Database Syst Rev. 2015 (11): Cd010907. https://doi.org/10.1002/14651858.CD010907.pub2. [19] 19 Heritage J, Elliott MN, Stivers T, Richardson A, Mangione-Smith R. Reducing inappropriate antibiotics prescribing: the role of online commentary on physical examination findings. Patient Educ Couns. 2010; 81(1):119-125. https://doi.org/10.1016/j.pec.2009.12.005. [20] 20 Stivers T, Mangione-Smith R, Elliott MN, McDonald L, Heritage J, Why do physicians think parents expect antibiotics? What parents report vs what physicians believe. J Family Practice. 2003;52(2):140-148. [21] 21 Price EL, Mackenzie TD, Metlay JP, Camargo CA Jr, Gonzales R. A computerised education module improves patient knowledge and attitudes about appropriate antibiotic use for acute respiratory tract infections. Patient Educ Couns. 2011:85(3):493-498. https://doi.org/10.1016/j.pec.2011.02.005. [22] 22 Lee GM, Friedman JF, Ross-Degnan D, Hibberd PL, Goldmann DA. Misconceptions about colds and predictors of health service utilisation. Pediatrics. 2003; 111(2):231-236. https://doi.org/10.1542/peds.111.2.231. [23] 23 Cabral C, Ingram J, Hay AD, Horwood J. "They just say everything's a virus"-parent's judgment of the credibility of clinical communication in primary care consultations for respiratory tract infections in children: a qualitative study. Patient Educ Couns.2014; 95(2):248-253. https://doi.org/10.1016/j.pec.2014.01.010. [24] 24 McNulty, C., Nichols, T., French, D., Joshi, P., & Butler, C. (2013). Expectations for consultations and antibiotics for respiratory tract infection in primary care: The RTI clinical iceberg. British journal of General Practice, 63(612),429-436. https://doi.org/10.3399/bjgp13X669149. [25] 25 Davies, J., & Davies, D. (2010). Origins and evolution of antibiotic resistance. Microbiology and Molecular Biology Reviews, 74(3), 417-433 https://doi.org/10.1128/MMBR.00016-10. [26] 26 McNulty, C., Boyle, P., Nichols, T., Clappison, P., & Davey, P. (2007). The public’s attitudes to and compliance with antibiotics. Journal of Antimicrobial Chemotherapy, 60(Suppl. 1), 63-68. https://doi.org/10.1093/jac/dkm161. [27] 27 Ensuring access to working antimicrobials, Report 2014-2015 (2014), The House of Commons. [28] 28 WHO (2018) Report on surveillance of antibiotic consumption: 2016-2018 early implementation. Geneva: WHO [29] 29 Laxminarayan R et al. (2013) 'Antibiotic resistance-the need for global solutions' The Lancet Infectious Disease Commission, 13, 1057-1098. https://doi.org/10.1016/S1473-3099(13)70318-9. [30] 30 Department of Health (2013). UK 5 year antimicrobial resistance strategy 2013-2018. London: Department of Health. [31] 31 Anderson A. (2018). Online health information and public knowledge, attitudes, and behaviours regarding antibiotics in the UK: Multiple regression analysis of Wellcome Monitor and Eurobarometer Data. PloS one, 13(10), e0204878. https://doi.org/10.1371/journal.pone.0204878. [32] 32 Ipsos MORI. Wellcome Trust Monitor, Wave 3. 2016. London: Wellcome Trust. Available from: https://wellcome.ac.uk/sites/default/files/monitor-wave3-full-wellcome-apr16.pdf. [33] 33 TNS Opinion. Special Eurobarometer 445: Antimicrobial Resistance. 10.2875/760366 Available from:https;//ec.europa.eu/health/amr/sites/amr/files/eb445_amr_generalreport_en.pdf. Public Health England (2015). English surveillance programme for antimicrobial utilisation and resistance (ESPAUR) 2010 to 2014. London [34] 34 Gualano MR, Gili R, Scaioli G, Bert F, Siliquini R. General population’s knowledge and attitudes about antibiotics: a systematic review and metaanalysis. Pharmacoepidemiology and Drug Safety. 2014; 24: 2– https://doi.org/10.1002/pds.3716. [35] 35 McNulty CAM, Boyle P, Nichols T, Clappison P, Davey P. Don’t wear me out–the public’s knowledge of and attitudes to antibiotic use. J Antimicrob Chemother. 2007; 59: 727–738. 10.1093/jac/dkl558 https://doi.org/10.1093/jac/dkl558. [36] 36 Fredericks I, Hollingworth S, Pudmenzky A, Rossato L, Syed S, Kairuz T. Consumer knowledge and perceptions about antibiotics and upper respiratory tract infections in a community pharmacy. Int J Clin Pharm. 2015; 37: 1213–1221. 10.1007/s11096-015-0188- y https://doi.org/10.1007/s11096-015-0188-y. [37] 37 PavydÄ— E, Veikutis V, MaÄiulienÄ— A, MaÄiulis V, Petrikonis K, StankeviÄius E. Public Knowledge, Beliefs and Behavior on Antibiotic Use and Self-Medication in Lithuania. Int J Environ Res Public Health. 2015; 12: 7002–7016. 10.3390/ijerph120607002 https://doi.org/10.3390/ijerph120607002. [38] 38 Kim SS, Moon S, Kim EJ. Public Knowledge and Attitudes Regarding Antibiotic Use in South Korea. J Korean Acad Nurs. 2011;41(6): 742–749. 10.4040/jkan.2011.41.6.742 https://doi.org/10.4040/jkan.2011.41.6.742. [39] 39 Jamhour A, El-Kheir A, Salameh P, Hanna PA, Mansour H. Antibiotic knowledge and self-medication practices in a developing country: A crosssectional study. Am J Infect Control. 2017;45: 384–388. 10.1016/j.ajic.2016.11.026 https://doi.org/10.1016/j.ajic.2016.11.026. SPC Journal of Social Sciences 15 [40] 40 Centers for Disease Control and Prevention. Antibiotic Use in the United States, 2017: Progress and Opportunities. Atlanta, GA: Centers for Disease Control and Prevention;2017 [41] 41 Riggs KR, Ubel PA, Saloner B. Can appeal to patient altruism reduce overuse of health care services? An experimental survey. J Gen Intern Med.2017;32(7):732-738. https://doi.org/10.1007/s11606-017-4002-5. [42] 42 Coxeter PD, Mar CD, Hoffmann TC. Parents’ expectations and experiences of antibiotics for acute respiratory infections in primary care. Ann Family Med. 2017;15(2):149-154 https://doi.org/10.1370/afm.2040. [43] 43 Feldman, MD. Altruism and medical practice. J Gen Intern Med.2017;32(7):719-720. https://doi.org/10.1007/s11606-017-4067-1. [44] 44 Guidos RJ, Infectious Diseases Society of America. Combating antimicrobial resistance: policy recommendations to save lives. Clin infect Dis. 2011;52(Suppl 5): S397-S428 https://doi.org/10.1093/cid/cir153. [45] 45 Centers for Disease Control and Prevention. The core elements of antibiotic stewardship for nursing homes. 2017. https://www.cdc.gov/longtermcare/prevention/antibiotic-stewardship.html.Accessed March 11, 2020 [46] 46 Sanchez GV, Fleming-Dutra KE, Roberts RM, Hicks LA. Core elements of outpatient antibiotic stewardship. MMWR Recommend Rep. 2016; 65(6):1-12 https://doi.org/10.15585/mmwr.rr6506a1. [47] 47 Centers for Disease Control and Prevention. Core elements of hospital antibiotic stewardship programs. 2015. https://www.cdc.gov/antibioticuse/healthcare/implementation/core-elements.html.Accessed March 11, 2020 [48] 48 Boivin A, Lehoux P, Lacombe R, Burgers J, Grol R. Involving patients in setting priorities for healthcare improvement: a cluster randomised trial. Implement Sci. 2014;9:24. https://doi.org/10.1186/1748-5908-9-24. [49] 49 Carman KL, Dardess P, Maurer M, et al. Patient and family engagement: a framework for understanding the elements and developing interventions and policies. Health Aff (Project Hope).2013;32(2):223-231. https://doi.org/10.1377/hlthaff.2012.1133. [50] 50 Domecq JP, Prutsky G, Elraiyah T, et al. Patient engagement in research: a systematic review. BMC Health Services Res. 2014;14:89. https://doi.org/10.1186/1472-6963-14-89. [51] 51 Ewers T. Knobloch MJ, Safdar N. Antimicrobial stewardship: the role of the patient. Curr Treat Options Infect Dis. 2017;9(1):92-103. https://doi.org/10.1007/s40506-017-0106-z. [52] 52 WHO (2015) Global Action Plan on Antimicrobial Resistance.Geneva: WHO [53] 53 Norwegian Ministry of Health and Care Services (2015) National Strategy against antibiotic resistance 2015-2020. Available at: https://www.regjeringen.no/en/dokumenter/national-strategy-against-antibiotic-resistance/id2424598 (Accessed: March 10 2020) [54] 54 European Commission (2017) The new EU One Health Action Plan against AMR. Available at:https://ec.europa.eu/health/amr/sites/health/files/antimicrobial_resistance/docs/amr_2017_action-plan.pdf (Accessed at March 12 2020) [55] 55 The European Commission (2016) Special Eurobarometer 445-April 2016. Brussels: European Commission, Available at https://ec.europa.eu/health/amr/sites/amr/files/eb445_amr_generalreport_en.pdf (Accessed: March 10 2020) [56] 56 Available at https://www.nhs.uk/news/medication/global-antibiotic-use-has-increased-sparking-fears-worldwide-resistance/ (Accessed July 30 2020) [57] 57 Norton Amy. (2018) Health Day News) Available at https://www.webmd.com/drug-medication/news/20181005/half-of-antibiotics-given-with-no- -infection-noted#1 (Accessed at July 30 2020) [58] 58 Laxminarayan R et al. (2013) 'Antibiotic resistance-the need for global solutions' The Lancet Infectious Diseases Commission, 13, 1057-1098. https://doi.org/10.1016/S1473-3099(13)70318-9. [59] 59 Nair M, Tripathi S, Mazumdar S, Mahajan R, Harshana A, Pereira A, et al. (2019) Knowledge, attitudes, and practices related to antibiotic use in Paschim Bardhaman District: A survey of healthcare providers in West Bengal, India. PLOS ONE 14(5):e0217818. https://doi.org/10.1371/journal.pone.0217818. [60] 60 Ahmed, S.M., Naher, N., Hossain, T. et al. Exploring the status of retail private drug shops in Bangladesh and action points for developing an accredited drug shop model: a facility-based cross-sectional study. J of Pharm Policy and Pract 10, 21 (2017). https://doi.org/10.1186/s40545-017- 0108-8. [61] 61 The Drugs and Cosmetics Act and Rules.2016. In Ministry of Health & Family Welfare, Government of India [Internet]. Available at (https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf Accessed March 05, 2020. [62] 62 Mate I, Come CE, Gonçalves MP, Cliff J, Gudo ES (2019) Knowledge, attitudes and practices regarding antibiotic use in Maputo City, Mozambique. PLOS ONE 14(8): e0221452. https://doi.org/10.1371/journal.pone.0221452. [63] 63 O’Neill J. Antimicrobial Resistance: Tackling a crisis for the health and wealth of nations. UK: Wellcome Trust, 2014. [64] 64 A. Cox et al.Antibiotic Stewardship in low- and middle-income countries: the same but different? Clinical Microbiology and infection 23 (2017) 812-818. https://doi.org/10.1016/j.cmi.2017.07.010. [65] 65 Radyowijati A, Haak H. Improving antibiotic use in low-income countries: an overview of evidence on determinants. Soc Sci Med 2003; 57:733- 44. https://doi.org/10.1016/S0277-9536(02)00422-7. [66] 66 McDonnell Norms Group, Antibiotic overuse: the influence of social norms. J Am Coll Surg 2008; 207: 265-75. [67] 67 Sumpradit N, Chongtrakul P, Anuwong K, et al. Antibiotics Smart Use: a workable model for promoting the rational use of medicines in Thailand. Bull World Health Organ 2012; 90:905-13. https://doi.org/10.2471/BLT.12.105445. [68] 68 Masiero G, Filippini M, Ferech M, Goossens H. Socioeconomic determinants of outpatient antibiotic use in Europe. Int J Public Health 2010; 55: 469-78. https://doi.org/10.1007/s00038-010-0167-y. [69] 69 Mintzes B. Pharmaceutical promotion and prevention of antibiotic resistance. Mastering anti-infective therapies. Paris: 2005. [70] 70 US Centers for Disease Control and Prevention (2013). Antibiotic resistance threats in the United States, US. Available at: https://www.cdc.gov/drugresistance/threat-report-2013/pdf/ar-threaths-2013-508.pdf (Accessed March 05, 2020) [71] 71 Morgan Dj, Okeke IN, Laxminarayan R, Perencevich EN, Weisenberg S. Non-prescription Antimicrobial use worldwide: a systematic review. Lancet Infect Dis 2011; 11:692-701. https://doi.org/10.1016/S1473-3099(11)70054-8. [72] 72 Planta MB. The role of poverty in antimicrobial resistance. J Am Board Fam Med 2007; 20: 533-39. https://doi.org/10.3122/jabfm.2007.06.070019. [73] 73 Minzi O, Manyilizu V. Application of basic pharmacology and dispensing practice of antibiotics in accredited drug –dispensing outlets in Tanzania. Drug Healthc Patient Saf 2013; 5: 5-11. [74] 74 WHO (2012) the Pursuit of Responsible Use of Medicines. Geneva: WHO [75] 75 Norwegian Ministry of Health and Care Services (2016) National Campaign against antibiotic resistance. Available at: https://www.regjeringen.no/no/aktuelt/nasjonal-kampanje-mot-antibiotikaresistens/id2500135/ (Accessed: March 10 2020). [76] 76 Available at: http://prisma-statement.org/documents/PRISMA%202009%20flow%20diagram.pdf [77] 77 Jairoun A, Hassan N, Ali A, Jairoun O, Shahwan M, Hassali M. (2019). 'University students’ knowledge, attitudes, and practice regarding antibiotic use and associated factors: a cross-sectional study in the United Arab Emirates', Int J Gen Med, 12, 235-246. https://doi.org/10.2147/IJGM.S200641. [78] 78 Waaseth, M., Adan, A., Røen, I. L., Eriksen, K., Stanojevic, T., Halvorsen, K. H., Garcia, B. H., Holst, L., Ulshagen, K. M., Blix, H. S., Ariansen, H., & Nordeng, H. (2019). 'Knowledge of antibiotics and antibiotic resistance among Norwegian pharmacy customers - a cross-sectional study'. BMC public health, 19(1), 66. https://doi.org/10.1186/s12889-019-6409-x. [79] 79 Al E, AA Albarraq and MA Abdallah. (2016). 'Saudi Parents' knowledge, Attitudes and Practices on Antibiotic Use for Upper Respiratory Tract Infections in Children: A population –based Survey; Taif, Kingdom of Saudi Arabia'. The Journal of Medical Research. 2. 99-103. [80] 80 Agarwal S, Yewale V. N & Dharmapalan D. (2015). 'Antibiotics Use and Misuse in Children: A Knowledge, Attitude and Practice Survey of Parents in India'. Journal of clinical and diagnostic research: JCDR, 9(11), SC21–SC24. https://doi.org/10.7860/JCDR/2015/14933.6819. 16 SPC Journal of Social Sciences [81] 81 Suaifan G, Shehadeh M, Darwish D, Ijel H, Yousef A and Darwish R. (2012).'A cross-sectional study on knowledge, attitude and behavior related to antibiotic use and resistance among medical and non-medical university students in Jordan'. African journal of pharmacy and pharmacology. 6(10), 763-770 https://doi.org/10.5897/AJPP12.080. [82] 82 Voidăzan, S., Moldovan, G., Voidăzan, L., Zazgyva, A., & Moldovan, H. (2019). 'Knowledge, Attitudes And Practices Regarding The Use Of Antibiotics. Study on the General Population Of MureÅŸ County, Romania'. Infection and drug resistance, 12, 3385–3396. https://doi.org/10.2147/IDR.S214574. [83] 83 Aljayyousi GF, Abdel-Rahman ME, El- Heneidy A, Kurdi R, Faisal E. (2019). 'Public practices on antibiotic use: A cross-sectional study among Qatar University students and their family members'. PLOS ONE 14(11): e0225499. https://doi.org/10.1371/journal.pone.0225499. [84] 84 MaziÅ„ska, B., Strużycka, I., & Hryniewicz, W. (2017). 'Surveys of public knowledge and attitudes with regard to antibiotics in Poland: Did the European Antibiotic Awareness Day campaigns change attitudes?'. PloS one, 12(2), e0172146. https://doi.org/10.1371/journal.pone.0172146. [85] 85 Shah, P., Shrestha, R., Mao, Z., Chen, Y., Chen, Y., Koju, P., Liu, X., & Li, H. (2019). 'Knowledge, Attitude, and Practice Associated with Antibiotic Use among University Students: A Survey in Nepal'. International journal of environmental research and public health, 16(20), 3996. https://doi.org/10.3390/ijerph16203996. [86] 86 McNulty CAM, Collin SM, Cooper E, et al. (2019). 'Public understanding and use of antibiotics in England: findings from a household survey in 2017'. BMJ Open 9:e030845. https://doi.org/10.1136/bmjopen-2019-030845. [87] 87 Cheng, J, Coope, C, Chai, J, et al. (2018). 'Knowledge and behaviors in relation to antibiotic use among rural residents in Anhui, China'. Pharmacoepidemiol Drug Saf. 27: 652– 659. https://doi.org/10.1002/pds.4429. [88] 88 Hajjar W, Alnassar S, Al-Khelb S, Al-Mutairi S, Al-Refayi N & Meo S. A. (2017). 'Antibiotics use and misuse in upper respiratory tract infection patients: Knowledge, attitude and practice analysis in University Hospital, Saudi Arabia'. JPMA. The Journal of the Pakistan Medical Association, 67(9), 1387–1392. https://doi.org/10.21474/IJAR01/3322. [89] 89 Ramchurren K, Balakrishna Y & Mahomed S. (2018).' Patients' knowledge, attitudes and practices regarding antibiotic use at a regional hospital in KwaZulu-Natal, South Africa 2017'. Southern African Journal of Infectious Diseases. https://doi.org/10.1080/23120053.2018.1516393. [90] 90 Teck KC, Ghazi HF, Bin Ahmad MI, et al. (2016). 'Knowledge, Attitude, and Practice of Parents Regarding Antibiotic Usage in Treating Children's Upper Respiratory Tract Infection at Primary Health Clinic in Kuala Lumpur, Malaysia: Pilot Study'. Health Serv Res Manag Epidemiol. 3:1-8 https://doi.org/10.1177/2333392816643720. [91] 91 Wang W, Wang X, Hu Y J, Wu D, Lu J, Xu Y, Sun C & Zhou X. (2019). 'The Misconception of Antibiotic Equal to an Anti-Inflammatory Drug Promoting Antibiotic Misuse among Chinese University Students'. International journal of environmental research and public health, 16(3), 335. https://doi.org/10.3390/ijerph16030335. [92] 92 . Omulo S, Thumbi SM, Lockwood S, Verani JR, Bigogo G, et al. (2017) 'Evidence of superficial knowledge regarding antibiotics and their use: Results of two cross-sectional surveys in an urban informal settlement in Kenya'. PLOS ONE 12(10): e0185827. https://doi.org/10.1371/journal.pone.0185827. [93] 93 Kurdi S, Faran A, Eareeni E, Alhalal N, Joseph R, Wali H and Alshayban D. (2019). 'Assessment of Knowledge and Attitude Toward the New Antibiotic Dispensing Law and its Effect on Antibiotic Use in Saudi Arabia'. Saudi Pharmaceutical Journal. 28(2020) 58-67 https://doi.org/10.1016/j.jsps.2019.11.005. [94] 94 Jairoun, A., Hassan, N., Ali, A. et al. (2019). 'Knowledge, attitude and practice of antibiotic use among university students: a cross sectional study in UAE'. BMC Public Health 19, 518 (2019). https://doi.org/10.1186/s12889-019-6878-y. [95] 95 Hu Y, Wang X, Tucker JD, Little P, Moore M, Fukuda K & Zhou X. (2018). 'Knowledge, Attitude, and Practice with Respect to Antibiotic Use among Chinese Medical Students: A Multicentre Cross-Sectional Study'. International Journal of Environmental Research and Public Health. 15(6):1165. https://doi.org/10.3390/ijerph15061165. [96] 96 Zajmi, D., Berisha, M., Begolli, I., Hoxha, R., Mehmeti, R., Mulliqi-Osmani, G., Kurti, A., Loku, A., & Raka, L. (2017). 'Public knowledge, attitudes and practices regarding antibiotic use in Kosovo'. Pharmacy practice, 15(1), 827. https://doi.org/10.18549/PharmPract.2017.01.827. [97] 97 Yezli S, Yassin S,Mushi A,Maashi F, Aljabri N, Mohamed G, Bieh K, Awam A & Alotaibi B. (2019). 'Knowledge, attitude and practice (KAP) survey regarding antibiotic use among pilgrims attending the 2015 Hajj mass gathering'. Travel Medicine and Infectious Disease,28 (March-April), Pages 52-58. https://doi.org/10.1016/j.tmaid.2018.08.004. [98] 98 Mate I, Come CE, Gonçalves MP, Cliff J, Gudo ES. (2019). 'Knowledge, attitudes and practices regarding antibiotic use in Maputo City, Mozambique'. PLOS ONE 14(8): e0221452. https://doi.org/10.1371/journal.pone.0221452. [99] 99 Rutschmann OT, Domino ME. Antibiotics for upper respiratory tract infections in ambulatory practice in the United States, 1997-1999: does physician specialty matter? J Am Board Fam Pract 2004; 17:196–200. https://doi.org/10.3122/jabfm.17.3.196. [100] 100 Britten N, Ukoumunne O. The influence of patients' hopes of receiving a prescription on doctors' perceptions and the decision to prescribe: a questionnaire survey. BMJ 1997; 315: 1506–1510. https://doi.org/10.1136/bmj.315.7121.1506. [101] 101 Kotwani A, Wattal C, Katewa S, Joshi P C and Holloway K. (2010). 'Factors influencing primary care physicians to prescribe antibiotics in Delhi India'. Family practice. 27. 684-90. 10.1093/fampra/cmq059. https://doi.org/10.1093/fampra/cmq059. [102] 102 Jelinek GA, Neate SL. (2009). ‘The influence of the pharmaceutical industry in medicine’, J Law Med, 17,216-23. [103] 103 Choi, K. H., Park, S. M., Lee, J. H., & Kwon, S. (2012). 'Factors affecting the prescribing patterns of antibiotics and injections', Journal of Korean medical science, 27(2), 120–127. https://doi.org/10.3346/jkms.2012.27.2.120. [104] 104 Pearce N.(2012). ‘Classification of epidemiological study designs’. Int J Epidemiol. 41: 393–397. pmid:22493323 https://doi.org/10.1093/ije/dys049. [105] 105 Parulekar MS, Rogers CK. (2018). ‘Polypharmacy and Mobility. In: Geriatric Rehabilitation’. Elsevier; p. 121–9. https://doi.org/10.1016/B978-0-323-54454-2.00009-1. [106] 106 Wang J. Sheng Y, Ni J, Zhu J, Zhou Z, Liu T, Zhang X & Zhao Q. (2019). 'Shanghai Parents' Perception and Attitude towards the Use of Antibiotics On Children: A Cross-Sectional Study'. Infection and drug resistance, 12, 3259–3267. https://doi.org/10.2147/IDR.S219287. [107] 107 World Health Organization. Global action plan on antimicrobial resistance [Internet]. Geneva; 2015. https://www.who.int/antimicrobial-resistance/global-action-plan/en/ (Accessed: August 24 2020) [108] 108 Alhomoud, F., Aljamea, Z. & Basalelah, L. (2018). “Antibiotics kill things very quickly†- consumers’ perspectives on non-prescribed antibiotic use in Saudi Arabia. BMC Public Health 18, 1177. https://doi.org/10.1186/s12889-018-6088-z. [109] 109 Sakeena, M., Bennett, A. A., Carter, S. J., & McLachlan, A. J. (2019). 'A comparative study regarding antibiotic consumption and knowledge of antimicrobial resistance among pharmacy students in Australia and Sri Lanka'. PloS one, 14(3), e0213520. https://doi.org/10.1371/journal.pone.0213520. [110] 110 Haenssgen MJ, Charoenboon N, Zanello G, et al. (2019). 'Antibiotic knowledge, attitudes and practices: new insights from cross-sectional rural health behaviour surveys in low-income and middle-income South-East Asia' BMJ Open:9:e028224. https://doi.org/10.1136/bmjopen-2018- 028224

1Porco et al. (2012). 'When Does Overuse of Antibiotics Become a Tragedy of the Commons?' Plos One, 7(12), e46505. https://doi.org/10.1371/journal.pone.0046505.
14 SPC Journal of Social Sciences
[2] 2 Leekha S, Terrell CL, Edson RS. General principles of antimicrobial therapy Mayo Clin Proc, 2011; 86(2):156-67. doi: 10.4065/mcp.2010.0636
Available at https://www.health.qld.gov.au/news-events/news/antibiotics-viruses-cold-flu. (Accessed: March 30 2020).
https://doi.org/10.4065/mcp.2010.0639.
[3] 3 US Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States, 2013. April 2013. https://www.cdc.gov/drugresistance/threat-report-2013/pdf/ar-threaths-2013-508.pdf (Accessed March 05 2020)
[4] 4 Available at https://www.health.qld.gov.au/news-events/news/antibiotics-viruses-cold-flu. (Accessed: March 30 2020)
[5] 5 Chaw P, Hopner J and Mikolajczyk R. (2018) ’The Knowledge, attitude and practice of health practitioners towards antibiotic prescribing and
resistance in developing countries-A systematic review’, Wileyonlinelibrary.com,(43),606. https://doi.org/10.1111/jcpt.12730.
[6] 6 Pereira JQ, Silva MT & Galvão TF. (2018). 'Use of antibiotics by adults: a population-based cross-sectional study'. Sao Paulo Medical Journal, 136(5), 407-413. https://doi.org/10.1590/1516-3180.2018.0168060818.
[7] 7 Sukkar, E. (2013). ‘Why are there so few antibiotics in the research and development pipeline?’ The Pharmaceutical Journal, 291, 520.
[8] 8 Harwood, C. ‘The rise of antibiotic resistance’ I-Sense. Available at: https://www.i-sense.org.uk/infectious-diseases/bacterial-infections/rise-antibiotic-resistance (Accessed: March 30 2020).
[9] 9 O’Neill, J. The review on antimicrobial resistance: tackling drug-resistant infections globally: final report and recommendations. (2016). https://amrreview.org/sites/default/files/160518_Final%20paper_with%20cover.pdf.
[10] 10 HM Government (2016). Review on antimicrobial resistance: Tackling drug-resistant infections globally. London. https://amrreview.org/sites/default/files/160525_Final%20paper_with%20cover.pdf. https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/477962/ESPAUR_Report_2015.pdf.
[11] 11 Available at https://www.cidrap.umn.edu/news-perspective/2018/03/price-pay-antibiotic-resistant-infections-cost-2-billion-year (Accessed March
15 2020)
[12] 12 Boseley, S. (2015) ‘Rising antibiotic resistance increasing risks of routine surgery-study’, The Guardian (UK), October 16. Available at:
https://www.theguardian.com/society/2015/oct/16/antibiotic-resistance-routine-surgery-impossible-study (Accessed:30 March 2020)
[13] 13 Centers for Disease Control and Prevention. Antibiotic Use in the United States, 2017: Progress and Opportunities. Atlanta, GA: US Department
of Health and Human Services, CDC; 2017. Available at: https://www.cdc.gov/antibiotic-use/stewardship-report/pdf/stewardship-report.pdf
[14] 14 ECDC/EMEA. Technical Report. The bacterial challenge: time to react.Sep2009.https://www.ecdc.europa.eu/sites/default/files/media/en/publications/0909 TER The Bacterial Challenge Time to React.pdf (Accessed March 05, 2020)
[15] 15 US Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States, 2013. April 2013. https://www.cdc.gov/drugresistance/threat-report-2013/pdf/ar-threaths-2013-508.pdf (Accessed March 05, 2020)
[16] 16 Alumran A et al., 'Antibiotic overuse in Children with Upper Respiratory tract infections in Saudi Arabia: risk factors and potential interventions'
(2011) Scientific & Academic Publishing; 1(1):8-16 https://doi.org/10.5923/j.cmd.20110101.02.
[17] 17 MD Rezal RS, Hassali MA, Alrasheedy AA, Saleem F, Md Yusof FA, Godman B. Physicians' knowledge, perceptions and behaviour to-wards
antibiotic prescribing: a systematic review of the literature. Expert Rev Anti Infect Ther.2015:13(5):665-680.
https://doi.org/10.1586/14787210.2015.1025057.
[18] 18 Coxeter P, Del Mar CB, McGregor L, Beller EM, Hoffmann TC. Interventions to facilitate shared decision making to address antibiotic use for
acute respiratory infections in primary care. Cochrane Database Syst Rev. 2015 (11): Cd010907. https://doi.org/10.1002/14651858.CD010907.pub2.
[19] 19 Heritage J, Elliott MN, Stivers T, Richardson A, Mangione-Smith R. Reducing inappropriate antibiotics prescribing: the role of online commentary
on physical examination findings. Patient Educ Couns. 2010; 81(1):119-125. https://doi.org/10.1016/j.pec.2009.12.005.
[20] 20 Stivers T, Mangione-Smith R, Elliott MN, McDonald L, Heritage J, Why do physicians think parents expect antibiotics? What parents report vs
what physicians believe. J Family Practice. 2003;52(2):140-148.
[21] 21 Price EL, Mackenzie TD, Metlay JP, Camargo CA Jr, Gonzales R. A computerised education module improves patient knowledge and attitudes
about appropriate antibiotic use for acute respiratory tract infections. Patient Educ Couns. 2011:85(3):493-498.
https://doi.org/10.1016/j.pec.2011.02.005.
[22] 22 Lee GM, Friedman JF, Ross-Degnan D, Hibberd PL, Goldmann DA. Misconceptions about colds and predictors of health service utilisation.
Pediatrics. 2003; 111(2):231-236. https://doi.org/10.1542/peds.111.2.231.
[23] 23 Cabral C, Ingram J, Hay AD, Horwood J. "They just say everything's a virus"-parent's judgment of the credibility of clinical communication in
primary care consultations for respiratory tract infections in children: a qualitative study. Patient Educ Couns.2014; 95(2):248-253.
https://doi.org/10.1016/j.pec.2014.01.010.
[24] 24 McNulty, C., Nichols, T., French, D., Joshi, P., & Butler, C. (2013). Expectations for consultations and antibiotics for respiratory tract infection in
primary care: The RTI clinical iceberg. British journal of General Practice, 63(612),429-436. https://doi.org/10.3399/bjgp13X669149.
[25] 25 Davies, J., & Davies, D. (2010). Origins and evolution of antibiotic resistance. Microbiology and Molecular Biology Reviews, 74(3), 417-433
https://doi.org/10.1128/MMBR.00016-10.
[26] 26 McNulty, C., Boyle, P., Nichols, T., Clappison, P., & Davey, P. (2007). The public’s attitudes to and compliance with antibiotics. Journal of
Antimicrobial Chemotherapy, 60(Suppl. 1), 63-68. https://doi.org/10.1093/jac/dkm161.
[27] 27 Ensuring access to working antimicrobials, Report 2014-2015 (2014), The House of Commons.
[28] 28 WHO (2018) Report on surveillance of antibiotic consumption: 2016-2018 early implementation. Geneva: WHO
[29] 29 Laxminarayan R et al. (2013) 'Antibiotic resistance-the need for global solutions' The Lancet Infectious Disease Commission, 13, 1057-1098.
https://doi.org/10.1016/S1473-3099(13)70318-9.
[30] 30 Department of Health (2013). UK 5 year antimicrobial resistance strategy 2013-2018. London: Department of Health.
[31] 31 Anderson A. (2018). Online health information and public knowledge, attitudes, and behaviours regarding antibiotics in the UK: Multiple regression analysis of Wellcome Monitor and Eurobarometer Data. PloS one, 13(10), e0204878. https://doi.org/10.1371/journal.pone.0204878.
[32] 32 Ipsos MORI. Wellcome Trust Monitor, Wave 3. 2016. London: Wellcome Trust. Available from: https://wellcome.ac.uk/sites/default/files/monitor-wave3-full-wellcome-apr16.pdf.
[33] 33 TNS Opinion. Special Eurobarometer 445: Antimicrobial Resistance. 10.2875/760366 Available from:https;//ec.europa.eu/health/amr/sites/amr/files/eb445_amr_generalreport_en.pdf. Public Health England (2015). English surveillance programme for antimicrobial utilisation and resistance (ESPAUR) 2010 to 2014. London
[34] 34 Gualano MR, Gili R, Scaioli G, Bert F, Siliquini R. General population’s knowledge and attitudes about antibiotics: a systematic review and metaanalysis. Pharmacoepidemiology and Drug Safety. 2014; 24: 2– https://doi.org/10.1002/pds.3716.
[35] 35 McNulty CAM, Boyle P, Nichols T, Clappison P, Davey P. Don’t wear me out–the public’s knowledge of and attitudes to antibiotic use. J Antimicrob Chemother. 2007; 59: 727–738. 10.1093/jac/dkl558 https://doi.org/10.1093/jac/dkl558.
[36] 36 Fredericks I, Hollingworth S, Pudmenzky A, Rossato L, Syed S, Kairuz T. Consumer knowledge and perceptions about antibiotics and upper
respiratory tract infections in a community pharmacy. Int J Clin Pharm. 2015; 37: 1213–1221. 10.1007/s11096-015-0188-
y https://doi.org/10.1007/s11096-015-0188-y.
[37] 37 PavydÄ— E, Veikutis V, MaÄiulienÄ— A, MaÄiulis V, Petrikonis K, StankeviÄius E. Public Knowledge, Beliefs and Behavior on Antibiotic Use and
Self-Medication in Lithuania. Int J Environ Res Public Health. 2015; 12: 7002–7016. 10.3390/ijerph120607002
https://doi.org/10.3390/ijerph120607002.
[38] 38 Kim SS, Moon S, Kim EJ. Public Knowledge and Attitudes Regarding Antibiotic Use in South Korea. J Korean Acad Nurs. 2011;41(6): 742–749.
10.4040/jkan.2011.41.6.742 https://doi.org/10.4040/jkan.2011.41.6.742.
[39] 39 Jamhour A, El-Kheir A, Salameh P, Hanna PA, Mansour H. Antibiotic knowledge and self-medication practices in a developing country: A crosssectional study. Am J Infect Control. 2017;45: 384–388. 10.1016/j.ajic.2016.11.026 https://doi.org/10.1016/j.ajic.2016.11.026.
SPC Journal of Social Sciences 15
[40] 40 Centers for Disease Control and Prevention. Antibiotic Use in the United States, 2017: Progress and Opportunities. Atlanta, GA: Centers for
Disease Control and Prevention;2017
[41] 41 Riggs KR, Ubel PA, Saloner B. Can appeal to patient altruism reduce overuse of health care services? An experimental survey. J Gen Intern
Med.2017;32(7):732-738. https://doi.org/10.1007/s11606-017-4002-5.
[42] 42 Coxeter PD, Mar CD, Hoffmann TC. Parents’ expectations and experiences of antibiotics for acute respiratory infections in primary care. Ann
Family Med. 2017;15(2):149-154 https://doi.org/10.1370/afm.2040.
[43] 43 Feldman, MD. Altruism and medical practice. J Gen Intern Med.2017;32(7):719-720. https://doi.org/10.1007/s11606-017-4067-1.
[44] 44 Guidos RJ, Infectious Diseases Society of America. Combating antimicrobial resistance: policy recommendations to save lives. Clin infect Dis.
2011;52(Suppl 5): S397-S428 https://doi.org/10.1093/cid/cir153.
[45] 45 Centers for Disease Control and Prevention. The core elements of antibiotic stewardship for nursing homes. 2017. https://www.cdc.gov/longtermcare/prevention/antibiotic-stewardship.html.Accessed March 11, 2020
[46] 46 Sanchez GV, Fleming-Dutra KE, Roberts RM, Hicks LA. Core elements of outpatient antibiotic stewardship. MMWR Recommend Rep. 2016;
65(6):1-12 https://doi.org/10.15585/mmwr.rr6506a1.
[47] 47 Centers for Disease Control and Prevention. Core elements of hospital antibiotic stewardship programs. 2015. https://www.cdc.gov/antibioticuse/healthcare/implementation/core-elements.html.Accessed March 11, 2020
[48] 48 Boivin A, Lehoux P, Lacombe R, Burgers J, Grol R. Involving patients in setting priorities for healthcare improvement: a cluster randomised trial.
Implement Sci. 2014;9:24. https://doi.org/10.1186/1748-5908-9-24.
[49] 49 Carman KL, Dardess P, Maurer M, et al. Patient and family engagement: a framework for understanding the elements and developing interventions
and policies. Health Aff (Project Hope).2013;32(2):223-231. https://doi.org/10.1377/hlthaff.2012.1133.
[50] 50 Domecq JP, Prutsky G, Elraiyah T, et al. Patient engagement in research: a systematic review. BMC Health Services Res. 2014;14:89.
https://doi.org/10.1186/1472-6963-14-89.
[51] 51 Ewers T. Knobloch MJ, Safdar N. Antimicrobial stewardship: the role of the patient. Curr Treat Options Infect Dis. 2017;9(1):92-103.
https://doi.org/10.1007/s40506-017-0106-z.
[52] 52 WHO (2015) Global Action Plan on Antimicrobial Resistance.Geneva: WHO
[53] 53 Norwegian Ministry of Health and Care Services (2015) National Strategy against antibiotic resistance 2015-2020. Available at:
https://www.regjeringen.no/en/dokumenter/national-strategy-against-antibiotic-resistance/id2424598 (Accessed: March 10 2020)
[54] 54 European Commission (2017) The new EU One Health Action Plan against AMR. Available at:https://ec.europa.eu/health/amr/sites/health/files/antimicrobial_resistance/docs/amr_2017_action-plan.pdf (Accessed at March 12 2020)
[55] 55 The European Commission (2016) Special Eurobarometer 445-April 2016. Brussels: European Commission, Available at https://ec.europa.eu/health/amr/sites/amr/files/eb445_amr_generalreport_en.pdf (Accessed: March 10 2020)
[56] 56 Available at https://www.nhs.uk/news/medication/global-antibiotic-use-has-increased-sparking-fears-worldwide-resistance/ (Accessed July 30
2020)
[57] 57 Norton Amy. (2018) Health Day News) Available at https://www.webmd.com/drug-medication/news/20181005/half-of-antibiotics-given-with-no-
-infection-noted#1 (Accessed at July 30 2020)
[58] 58 Laxminarayan R et al. (2013) 'Antibiotic resistance-the need for global solutions' The Lancet Infectious Diseases Commission, 13, 1057-1098.
https://doi.org/10.1016/S1473-3099(13)70318-9.
[59] 59 Nair M, Tripathi S, Mazumdar S, Mahajan R, Harshana A, Pereira A, et al. (2019) Knowledge, attitudes, and practices related to antibiotic use in
Paschim Bardhaman District: A survey of healthcare providers in West Bengal, India. PLOS ONE 14(5):e0217818. https://doi.org/10.1371/journal.pone.0217818.
[60] 60 Ahmed, S.M., Naher, N., Hossain, T. et al. Exploring the status of retail private drug shops in Bangladesh and action points for developing an
accredited drug shop model: a facility-based cross-sectional study. J of Pharm Policy and Pract 10, 21 (2017). https://doi.org/10.1186/s40545-017-
0108-8.
[61] 61 The Drugs and Cosmetics Act and Rules.2016. In Ministry of Health & Family Welfare, Government of India [Internet]. Available at
(https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf Accessed
March 05, 2020.
[62] 62 Mate I, Come CE, Gonçalves MP, Cliff J, Gudo ES (2019) Knowledge, attitudes and practices regarding antibiotic use in Maputo City, Mozambique. PLOS ONE 14(8): e0221452. https://doi.org/10.1371/journal.pone.0221452.
[63] 63 O’Neill J. Antimicrobial Resistance: Tackling a crisis for the health and wealth of nations. UK: Wellcome Trust, 2014.
[64] 64 A. Cox et al.Antibiotic Stewardship in low- and middle-income countries: the same but different? Clinical Microbiology and infection 23 (2017)
812-818. https://doi.org/10.1016/j.cmi.2017.07.010.
[65] 65 Radyowijati A, Haak H. Improving antibiotic use in low-income countries: an overview of evidence on determinants. Soc Sci Med 2003; 57:733-
44. https://doi.org/10.1016/S0277-9536(02)00422-7.
[66] 66 McDonnell Norms Group, Antibiotic overuse: the influence of social norms. J Am Coll Surg 2008; 207: 265-75.
[67] 67 Sumpradit N, Chongtrakul P, Anuwong K, et al. Antibiotics Smart Use: a workable model for promoting the rational use of medicines in Thailand.
Bull World Health Organ 2012; 90:905-13. https://doi.org/10.2471/BLT.12.105445.
[68] 68 Masiero G, Filippini M, Ferech M, Goossens H. Socioeconomic determinants of outpatient antibiotic use in Europe. Int J Public Health 2010; 55:
469-78. https://doi.org/10.1007/s00038-010-0167-y.
[69] 69 Mintzes B. Pharmaceutical promotion and prevention of antibiotic resistance. Mastering anti-infective therapies. Paris: 2005.
[70] 70 US Centers for Disease Control and Prevention (2013). Antibiotic resistance threats in the United States, US. Available at:
https://www.cdc.gov/drugresistance/threat-report-2013/pdf/ar-threaths-2013-508.pdf (Accessed March 05, 2020)
[71] 71 Morgan Dj, Okeke IN, Laxminarayan R, Perencevich EN, Weisenberg S. Non-prescription Antimicrobial use worldwide: a systematic review.
Lancet Infect Dis 2011; 11:692-701. https://doi.org/10.1016/S1473-3099(11)70054-8.
[72] 72 Planta MB. The role of poverty in antimicrobial resistance. J Am Board Fam Med 2007; 20: 533-39. https://doi.org/10.3122/jabfm.2007.06.070019.
[73] 73 Minzi O, Manyilizu V. Application of basic pharmacology and dispensing practice of antibiotics in accredited drug –dispensing outlets in Tanzania.
Drug Healthc Patient Saf 2013; 5: 5-11.
[74] 74 WHO (2012) the Pursuit of Responsible Use of Medicines. Geneva: WHO
[75] 75 Norwegian Ministry of Health and Care Services (2016) National Campaign against antibiotic resistance. Available at: https://www.regjeringen.no/no/aktuelt/nasjonal-kampanje-mot-antibiotikaresistens/id2500135/ (Accessed: March 10 2020).
[76] 76 Available at: http://prisma-statement.org/documents/PRISMA%202009%20flow%20diagram.pdf
[77] 77 Jairoun A, Hassan N, Ali A, Jairoun O, Shahwan M, Hassali M. (2019). 'University students’ knowledge, attitudes, and practice regarding antibiotic
use and associated factors: a cross-sectional study in the United Arab Emirates', Int J Gen Med, 12, 235-246. https://doi.org/10.2147/IJGM.S200641.
[78] 78 Waaseth, M., Adan, A., Røen, I. L., Eriksen, K., Stanojevic, T., Halvorsen, K. H., Garcia, B. H., Holst, L., Ulshagen, K. M., Blix, H. S., Ariansen,
H., & Nordeng, H. (2019). 'Knowledge of antibiotics and antibiotic resistance among Norwegian pharmacy customers - a cross-sectional study'. BMC
public health, 19(1), 66. https://doi.org/10.1186/s12889-019-6409-x.
[79] 79 Al E, AA Albarraq and MA Abdallah. (2016). 'Saudi Parents' knowledge, Attitudes and Practices on Antibiotic Use for Upper Respiratory Tract
Infections in Children: A population –based Survey; Taif, Kingdom of Saudi Arabia'. The Journal of Medical Research. 2. 99-103.
[80] 80 Agarwal S, Yewale V. N & Dharmapalan D. (2015). 'Antibiotics Use and Misuse in Children: A Knowledge, Attitude and Practice Survey of
Parents in India'. Journal of clinical and diagnostic research: JCDR, 9(11), SC21–SC24. https://doi.org/10.7860/JCDR/2015/14933.6819.
16 SPC Journal of Social Sciences
[81] 81 Suaifan G, Shehadeh M, Darwish D, Ijel H, Yousef A and Darwish R. (2012).'A cross-sectional study on knowledge, attitude and behavior related
to antibiotic use and resistance among medical and non-medical university students in Jordan'. African journal of pharmacy and pharmacology. 6(10),
763-770 https://doi.org/10.5897/AJPP12.080.
[82] 82 Voidăzan, S., Moldovan, G., Voidăzan, L., Zazgyva, A., & Moldovan, H. (2019). 'Knowledge, Attitudes And Practices Regarding The Use Of
Antibiotics. Study on the General Population Of Mureş County, Romania'. Infection and drug resistance, 12, 3385–3396.
https://doi.org/10.2147/IDR.S214574.
[83] 83 Aljayyousi GF, Abdel-Rahman ME, El- Heneidy A, Kurdi R, Faisal E. (2019). 'Public practices on antibiotic use: A cross-sectional study among
Qatar University students and their family members'. PLOS ONE 14(11): e0225499. https://doi.org/10.1371/journal.pone.0225499.
[84] 84 Mazińska, B., Strużycka, I., & Hryniewicz, W. (2017). 'Surveys of public knowledge and attitudes with regard to antibiotics in Poland: Did the
European Antibiotic Awareness Day campaigns change attitudes?'. PloS one, 12(2), e0172146. https://doi.org/10.1371/journal.pone.0172146.
[85] 85 Shah, P., Shrestha, R., Mao, Z., Chen, Y., Chen, Y., Koju, P., Liu, X., & Li, H. (2019). 'Knowledge, Attitude, and Practice Associated with
Antibiotic Use among University Students: A Survey in Nepal'. International journal of environmental research and public health, 16(20), 3996.
https://doi.org/10.3390/ijerph16203996.
[86] 86 McNulty CAM, Collin SM, Cooper E, et al. (2019). 'Public understanding and use of antibiotics in England: findings from a household survey in
2017'. BMJ Open 9:e030845. https://doi.org/10.1136/bmjopen-2019-030845.
[87] 87 Cheng, J, Coope, C, Chai, J, et al. (2018). 'Knowledge and behaviors in relation to antibiotic use among rural residents in Anhui, China'. Pharmacoepidemiol Drug Saf. 27: 652– 659. https://doi.org/10.1002/pds.4429.
[88] 88 Hajjar W, Alnassar S, Al-Khelb S, Al-Mutairi S, Al-Refayi N & Meo S. A. (2017). 'Antibiotics use and misuse in upper respiratory tract infection
patients: Knowledge, attitude and practice analysis in University Hospital, Saudi Arabia'. JPMA. The Journal of the Pakistan Medical Association, 67(9), 1387–1392. https://doi.org/10.21474/IJAR01/3322.
[89] 89 Ramchurren K, Balakrishna Y & Mahomed S. (2018).' Patients' knowledge, attitudes and practices regarding antibiotic use at a regional hospital
in KwaZulu-Natal, South Africa 2017'. Southern African Journal of Infectious Diseases. https://doi.org/10.1080/23120053.2018.1516393.
[90] 90 Teck KC, Ghazi HF, Bin Ahmad MI, et al. (2016). 'Knowledge, Attitude, and Practice of Parents Regarding Antibiotic Usage in Treating Children's
Upper Respiratory Tract Infection at Primary Health Clinic in Kuala Lumpur, Malaysia: Pilot Study'. Health Serv Res Manag Epidemiol. 3:1-8
https://doi.org/10.1177/2333392816643720.
[91] 91 Wang W, Wang X, Hu Y J, Wu D, Lu J, Xu Y, Sun C & Zhou X. (2019). 'The Misconception of Antibiotic Equal to an Anti-Inflammatory Drug
Promoting Antibiotic Misuse among Chinese University Students'. International journal of environmental research and public health, 16(3), 335.
https://doi.org/10.3390/ijerph16030335.
[92] 92
. Omulo S, Thumbi SM, Lockwood S, Verani JR, Bigogo G, et al. (2017) 'Evidence of superficial knowledge regarding antibiotics and their use:
Results of two cross-sectional surveys in an urban informal settlement in Kenya'. PLOS ONE 12(10): e0185827. https://doi.org/10.1371/journal.pone.0185827.
[93] 93 Kurdi S, Faran A, Eareeni E, Alhalal N, Joseph R, Wali H and Alshayban D. (2019). 'Assessment of Knowledge and Attitude Toward the New
Antibiotic Dispensing Law and its Effect on Antibiotic Use in Saudi Arabia'. Saudi Pharmaceutical Journal. 28(2020) 58-67
https://doi.org/10.1016/j.jsps.2019.11.005.
[94] 94 Jairoun, A., Hassan, N., Ali, A. et al. (2019). 'Knowledge, attitude and practice of antibiotic use among university students: a cross sectional study
in UAE'. BMC Public Health 19, 518 (2019). https://doi.org/10.1186/s12889-019-6878-y.
[95] 95 Hu Y, Wang X, Tucker JD, Little P, Moore M, Fukuda K & Zhou X. (2018). 'Knowledge, Attitude, and Practice with Respect to Antibiotic Use
among Chinese Medical Students: A Multicentre Cross-Sectional Study'. International Journal of Environmental Research and Public Health.
15(6):1165. https://doi.org/10.3390/ijerph15061165.
[96] 96 Zajmi, D., Berisha, M., Begolli, I., Hoxha, R., Mehmeti, R., Mulliqi-Osmani, G., Kurti, A., Loku, A., & Raka, L. (2017). 'Public knowledge,
attitudes and practices regarding antibiotic use in Kosovo'. Pharmacy practice, 15(1), 827. https://doi.org/10.18549/PharmPract.2017.01.827.
[97] 97 Yezli S, Yassin S,Mushi A,Maashi F, Aljabri N, Mohamed G, Bieh K, Awam A & Alotaibi B. (2019). 'Knowledge, attitude and practice (KAP)
survey regarding antibiotic use among pilgrims attending the 2015 Hajj mass gathering'. Travel Medicine and Infectious Disease,28 (March-April),
Pages 52-58. https://doi.org/10.1016/j.tmaid.2018.08.004.
[98] 98 Mate I, Come CE, Gonçalves MP, Cliff J, Gudo ES. (2019). 'Knowledge, attitudes and practices regarding antibiotic use in Maputo City, Mozambique'. PLOS ONE 14(8): e0221452. https://doi.org/10.1371/journal.pone.0221452.
[99] 99 Rutschmann OT, Domino ME. Antibiotics for upper respiratory tract infections in ambulatory practice in the United States, 1997-1999: does
physician specialty matter? J Am Board Fam Pract 2004; 17:196–200. https://doi.org/10.3122/jabfm.17.3.196.
[100] 100 Britten N, Ukoumunne O. The influence of patients' hopes of receiving a prescription on doctors' perceptions and the decision to prescribe: a
questionnaire survey. BMJ 1997; 315: 1506–1510. https://doi.org/10.1136/bmj.315.7121.1506.
[101] 101 Kotwani A, Wattal C, Katewa S, Joshi P C and Holloway K. (2010). 'Factors influencing primary care physicians to prescribe antibiotics in
Delhi India'. Family practice. 27. 684-90. 10.1093/fampra/cmq059. https://doi.org/10.1093/fampra/cmq059.
[102] 102 Jelinek GA, Neate SL. (2009). ‘The influence of the pharmaceutical industry in medicine’, J Law Med, 17,216-23.
[103] 103 Choi, K. H., Park, S. M., Lee, J. H., & Kwon, S. (2012). 'Factors affecting the prescribing patterns of antibiotics and injections', Journal of
Korean medical science, 27(2), 120–127. https://doi.org/10.3346/jkms.2012.27.2.120.
[104] 104 Pearce N.(2012). ‘Classification of epidemiological study designs’. Int J Epidemiol. 41: 393–397. pmid:22493323
https://doi.org/10.1093/ije/dys049.
[105] 105 Parulekar MS, Rogers CK. (2018). ‘Polypharmacy and Mobility. In: Geriatric Rehabilitation’. Elsevier; p. 121–9.
https://doi.org/10.1016/B978-0-323-54454-2.00009-1.
[106] 106 Wang J. Sheng Y, Ni J, Zhu J, Zhou Z, Liu T, Zhang X & Zhao Q. (2019). 'Shanghai Parents' Perception and Attitude towards the Use of
Antibiotics On Children: A Cross-Sectional Study'. Infection and drug resistance, 12, 3259–3267. https://doi.org/10.2147/IDR.S219287.
[107] 107 World Health Organization. Global action plan on antimicrobial resistance [Internet]. Geneva; 2015. https://www.who.int/antimicrobial-resistance/global-action-plan/en/ (Accessed: August 24 2020)
[108] 108 Alhomoud, F., Aljamea, Z. & Basalelah, L. (2018). “Antibiotics kill things very quickly†- consumers’ perspectives on non-prescribed antibiotic use in Saudi Arabia. BMC Public Health 18, 1177. https://doi.org/10.1186/s12889-018-6088-z.
[109] 109 Sakeena, M., Bennett, A. A., Carter, S. J., & McLachlan, A. J. (2019). 'A comparative study regarding antibiotic consumption and knowledge
of antimicrobial resistance among pharmacy students in Australia and Sri Lanka'. PloS one, 14(3), e0213520. https://doi.org/10.1371/journal.pone.0213520.
[110] 110 Haenssgen MJ, Charoenboon N, Zanello G, et al. (2019). 'Antibiotic knowledge, attitudes and practices: new insights from cross-sectional
rural health behaviour surveys in low-income and middle-income South-East Asia' BMJ Open:9:e028224. https://doi.org/10.1136/bmjopen-2018-
028224.

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