Pharmacokinetic interaction of nitroxynil and cefoperazone in goats

  • Authors

    • Mohamed El-hewaity
    2015-06-21
    https://doi.org/10.14419/ijbas.v4i3.4648
  • Kinetic, Interaction, Nitroxynil, Cefoperazone, Goat.
  • Abstract

    The pharmacokinetic aspects of cefoperazone (CEFO) were investigated via intravenous (IV), and intramuscular (IM) injections in clinically healthy goats at a dose of 20 mg/kg b.wt. Goats were pre-treated with nitroxynil (25%) or nitroxynil (34%) subcutaneously in a dose 10 mg/kg b.wt, respectively. Cefoperazone was injected intramuscularly nine hours following anthelmintic administration, and blood samples were taken by jugular venipuncture at standardized intervals. Cefoperazone concentrations in serum were determined by microbiological assay technique. Goats pre-treated with nitroxynil (25%) or nitroxynil (34%) showed a significant decrease in serum cefoperazone level as compared to non-anthelmintic treated goats. The obtained data revealed that administration of nitroxynil in both concentrations negatively affected most of the cefoperazone parameters. In this respect, the elimination half-life T0.5(el), Cmax, AUC, and the systemic bioavailability (F %) were significantly decreased in both groups of nitroxynil-treated goats compared to non-anthelmintic treated goats. On the other hand, there were no significance differences between both nitroxynil (25% and 34%) treated goats. Concomitant administration of nitroxynil (25% and 34%) with cefoperazone resulted in significant alterations in the disposition kinetic of cefoperazone in goats. Consequently, the interaction between nitroxynil and cefoperazone could be of clinical significance and may require monitoring and adjustment of cefoperazone dosage.

  • References

    1. [1] T.B. Barragry, Beta-lactam antibiotics. Veterinary Drug Therapy Lea & Febiger, Philadelphia, PA., (1994) 221-240.

      [2] A.L. Soraci, N. Mestorino and J. Errecalde, Concentration of Cefoperazone in synovial fluid and in bone after intramuscular administration. Revist. Med. Vet. Buen. Aire, (79) (1998) 148-150.

      [3] S. Soback, A. Bor, R. Paz and G. Ziv, Clinical pharmacology of mecillinam in calves. Journal of Veterinary Pharmacology and Therapeutics, (9) (1986) 385-393. http://dx.doi.org/10.1111/j.1365-2885.1986.tb00059.x.

      [4] L. Jiang, Q. Peng and Y. Yao, Penetration of ciprofloxacin and cefoperazone into human pancreas. Hua. Xi. Yi. Ke. Da. Xue. Xue. Bao. (28) (1997) 365-368.

      [5] T. Bergan, Pharmacokinetic properties of the cephalosporins. Drugs, (34) (1987) 89-104. http://dx.doi.org/10.2165/00003495-198700342-00008.

      [6] D. Wittman, Bone concentrations of six new betalactam antibiotics. 6th International Cefoperazone Symposium. Program and Abstracts. April-May Tokyo. (1982) P 9.

      [7] A.Q. Mckellar and D.B. Kinabo, The pharmacology of flukicidal drugs. British Veterinary Journal, (147) (1991) p. 306-321. http://dx.doi.org/10.1016/0007-1935(91)90003-6.

      [8] M.A.O. Almeida and M.C.C. Ayres, Agentes anticestódeos e antitrematódeos. In: Spinosa, H.S.; Goniak, S.L.; Bernardi, M.M. Farmacologia Aplicada a Medicina Veterinária, 5a ed. Rio de Janeiro: Guanabara Koogan, cap. (44) (2011) p. 510-516.

      [9] C.R. Reinemeyer and C.H. Courteny, Fármacos Anticestóides e antitrematóides. In: Adams, H.R. Farmacologia e terapêutica em veterinária, 8a ed. Rio de Janeiro: Guanabara Koogan, cap. (48) (2003) p. 819-828.

      [10] A.F.T. Amarante, Profilaxia da verminose ovina, descontaminação de pastagens. In: Silva Sobrinho, A.G. (Ed.). Produção de Ovinos, Jaboticabal: FUNEP, cap. (18) (1990) p. 201-210.

      [11] M.M. Bernardi, Exposição aos Medicamentos Durante o Período Perinatal. In: Spinosa, H.S.; Gorniak, S.L.; Bernardi, M.M. Farmacologia Aplicada a Medicina Veterinária, 4a ed. Rio de Janeiro: Guanabara Koogan, cap. (63) (2006) p. 807-816.

      [12] S. Soback and G. Ziv, pharmacokinetics of Single doses of cefoperazone given by the intravenous and intramuscular routes to unweaned calves. Research in Veterinary Science, (47) (1989) 158-163.

      [13] A.L. Soraci, N. Mestorino and J. Errecalde, Pharmacokinetics of cefoperazone in horses. Journal of Veterinary Pharmacology and Therapeutics, (19) (1996) 39-43. http://dx.doi.org/10.1111/j.1365-2885.1996.tb00006.x.

      [14] C. Montesissa, R. Villa, P. Anfossic, R. Zanonic and S. Carlib, Pharmacodynamics and pharmacokinetics of cefoperazone and cefamandol in dogs following single dose i.v. and i.m. administration. Veterinary Journal, (166) (2003) 170-176. http://dx.doi.org/10.1016/S1090-0233(03)00051-0.

      [15] S. Goyal, R.K. Chaudhary and A.K. Srivastava, Pharmacokinetics of cefoperazone in buffalo calves following its intravenous administration. Journal of Veterinary Pharmacology and Toxicology, (3) (2003) 104-108.

      [16] S. Goyal, R.K. Chaudhary and A.K. Srivastava, Pharmacokinetics following intramuscular administration and dosage regimen for cefoperazone in buffalo calves. Indian Journal of animal science, (75) (2005) 31-32.

      [17] J.K. Gupta, R.K. Chaudhary and V.K. Dumka, Cefoperazone pharmacokinetics following single intravenous administration in cross bred calves. Israel Journal of Veterinary Medicine, (62) (2007) 87-90.

      [18] J.K. Gupta, R.K. Chaudhary and V.K. Dumka, Pharmacokinetics after single intramuscular administration and in vitro plasma protein binding of Cefoperazone in cross bred calves. Veterinarski arhiv. (78) (2008) 441-448.

      [19] H.H. Soni, R.J. Patel, K.A. Sadariya, S.S. Devada, S.K. Bhavsar and A.M. Thaker, Single dose pharmacokinetics of cefoperazone following intravenous and intramuscular administration in sheep. Israel Journal of Veterinary Medicine, (67) (2012) 220-224.

      [20] G.C. Brander, D.M. Pugh, R.J. Baywater and W.L. Jenkins, Veterinary applied pharmacology and therapeutics. Fifth Ed., the English language Book Society and Boilliere, Trindall, London (1991).

      [21] B. Arret, D. Johnson and A. Kirshboum, Outline of details for microbiological assay of antibiotics, second revision. Pharmacology Science, (60) (1971) 1689-1694.

      [22] A.W. Craig and B. Suh, Protein binding and the antibacterial effects: methods for determination of protein binding. In: Lorian, V. (Ed), Antibiotics in Laboratory Medicine†Williams and Wilkins Baltimore, MD, (1980) pp. 265-297.

      [23] K. Yamaoka, T. Nakagawa and T. Uno, Statistical moment in pharmacokinetics. Journal of Pharmacokinetic and Biopharmaceutics, (6) (1978) 547-558.

      [24] G. W. Snedecor and T. Cochran, Statistical Methods 6th ed. pp. Ames, lowa U.S.A., (1976) 502-503.

      [25] S. Carli, C. Montesissa, O. Sonzogni and M. Madonna, Pharmacokinetics of sodium cefoperazone in calves. Pharmacological Research Communications, (18) (1986) 481-490. http://dx.doi.org/10.1016/0031-6989(86)90168-2.

      [26] S. Prawez, R. Raina, D. Dimitrova, N. Pankaj, A. Ahanger and P. Verma, The pharmacokinetics of cefepime in goats following single-dose i.v. and i.m. administration. Turkish Journal of Veterinary and Animal Science, (34) (2010) 427-431.

      [27] M. Ismail, Pharmacokinetics of cefepime administered by i.v and i.m. routes to ewes. Journal of Veterinary Pharmacology and Therapeutics, (28) (2005) 499-503. http://dx.doi.org/10.1111/j.1365-2885.2005.00689.x.

      [28] S. Barriere and J. Flaherty, Third generation cephalosporins: A critical evaluation. Clinical Pharmacology, (3) (1984) 351-373.

      [29] A.W. Craig, Pharmacokinetic/pharmacodynamic parameters. Rationale for antibacterial dosing of mice and men. Clinical Infectious Disease, (26) (1998) 1-12. http://dx.doi.org/10.1086/516284.

      [30] M. Atef, A.Y. El-Gendi, M.M. Aziza and A.M. Abd El-Aty, Effect of three anthelmentics on disposition kinetics of florfenicol in goats. Food and Chemical Toxicology (48) (2010) 3340–3344. http://dx.doi.org/10.1016/j.fct.2010.08.039.

      [31] K. Abo El-Sooud, Influence of albendazole on the disposition kinetics and milk antimicrobial equivalent activity of enrofloxacin in lactating goats. Pharmacological Research, 48 (2003) 389-395. http://dx.doi.org/10.1016/S1043-6618(03)00179-8.

      [32] M. Goodman and A.G. Gilmans, The pharmacological basis of therapeutics. 9th edition, Mc Graw – Hill Companies, (1995) pp. 14–15.

  • Downloads

  • How to Cite

    El-hewaity, M. (2015). Pharmacokinetic interaction of nitroxynil and cefoperazone in goats. International Journal of Basic and Applied Sciences, 4(3), 291-296. https://doi.org/10.14419/ijbas.v4i3.4648

    Received date: 2015-04-19

    Accepted date: 2015-05-18

    Published date: 2015-06-21