HPV Sensing by CNTFET Array Nanobiosensor.

  • Authors

    • Santhosh Kumar D. R
    • Dr P.V. Rao
    2018-09-01
    https://doi.org/10.14419/ijet.v7i3.34.18778
  • cancer, CNTFET, HPV, nano electronics, sensor array
  • Abstract

    Women life is threatened by the cervical cancer each time worldwide. The cervical cancer high grade pre cancer is due to HPV E6 and E7 agents. Nano materials show a key role in medical analysis and action. CNTs (Carbon Nano Tube) have very unique electrical and mechanical properties which are useful in the bio-application. The conventional based biosensors can be improved by CNT based biosensors with respect to sensitivity, selectivity and simple in operation. In comparison with the silicon transistors, CNTFET (Carbon Nano Tube Field Effect Transistor) nano device takes less power and performs faster. The research paper covers working of CNTFET based nano biosensor to detect cervical cancer antibody. 4 x 4 CNTFET sensor array is designed to detect antibody variations on CNTFET gate. The sensor current varied from 4.286 µA to 15.435 µA for gate voltage varied from 0.2 V to 1.06 V. The improved 64 CNTFET based biosensor performs better in sensing the analyte of different concentrations.

     

     

  • References

    1. [1] Dikshit, Prakash C Gupta et al., for the Million Death Study Collaborators. Cancer mortality in India: a nationally representative survey.www.thelancet.com Published online March 28, 2012; DOI: 10.1016/S0140-6736(12)60358-4.

      [2] Justin O. Parkhurst & MadhulikaVulimiri (2013) Cervical cancer and the global health agenda: Insights from multiple policy-analysis frameworks, Global Public Health: An International Journal for Research, Policy and Practice, 8:10, 1093-1108,DOI:10.1080/17441692.2013.850524. http://dx.doi.org/10.1080/17441692.2013.850524.

      [3] Chankapa YD, Pal R, Tsering D, Correlates of cervical cancer screening among underserved women. Indian Journal of Cancer | January–March 2011 |Volume 48 | Issue 1. 10.4103/0019-509X.75823.

      [4] Vesco KK et al, Screening for Cervical Cancer: A Systematic Evidence Review for the U.S. Preventive Services Task Force. Evidence Synthesis No. 86. AHRQ Publication No. 11-05156-EF-1. Rockville, MD: Agency for Healthcare Research and Quality; May 2011.

      [5] Neerja Bhatia et al., Evaluation of adjunctive tests for cervical cancer screening in low resource settings. Indian Journal of Cancer, April–June 2007, Volume 44, Issue 2.

      [6] Gouvêa CMCP (2011) Biosensors for health applications. Universidade.

      [7] Ngoepe M, Choonara YE, Tyagi C, Tomar LK, du Toit LC, Kumar,P, Ndesendo VMK, Pillay V (2013) Integration of biosensors,and drug delivery technologies for early detection and chronic management of illness. Sensors 13:7680–7713. doi:10.3390/s130607680.

      [8] Fracchiolla NS, Artuso S, Cortelezzi A (2013) Biosensors in clinical practice: focus on oncohematology. Sensors 13:6423–6447.doi:10.3390/s130506423.

      [9] Mohammad Hossein Moaiyeri, Reza Faghih Mirzaee, Keivan Navi and Omid Hashemipour, ―Efficient CNTFET-based Ternary Full Adder Cells for Nanoelectronics‖, Nano-Micro Lett.3(1), 43-50 (2011). http://dx.doi.org/10.3786/nml.v3i1.p43-50

      [10] N. Azizah, U.Hashim, Sh. Nadzirah, A. Rahim Ruslinda, Rapid and sensitive strategy for Human Papillomavirus (HPV) detection using a gene-based DNA nanobiosensor, in: Biomedical Engineering and Sciences (IECBES), 2014 IEEE Conference on, IEEE, 2014.

      [11] J. Deng, H.-S.P. Wong, A compact SPICE model for carbonnanotube field-effect transistors including nonidealities and its application—Part I:Model of the intrinsic channel region, IEEE Trans. Electron Devices 54 (12) (2007) 3186–3194.

      [12] S. Ashok Kumar, T. Shanmuganantham, Implantable CPW Fed Monopole H-slot Antenna for 2.45 GHz ISM Band

      [13] Applications, Int. J. Electron. Commun., Elsevier Publications

      [14] 68 (7) (2014) 661–666.

      [15] F.R. Madriz et al, Circuit modeling of high-frequency electrical conduction in carbon nanofibers, IEEE Trans. Electron Devices 56 (8) (2009) 1557–1561.

      [16] S. Ushaa, M. Madhavilatha, G.M. Rao, Design and analysis of nanowire sensor array for prostate cancer detection, Int. J. Nano Biomater. 3 (3) (2011) 239–255.

      [17] B.N. Shobha, N. J. R. Muniraj, Design, Modeling and Simulation of Prostate Cancer Biosensor with ssDNA biomarker and DGFET Biosensor (IJCSIT) International Journal of Computer Science and Information Technologies, Vol. 5 (2), 2014, 2612-2620.

      [18] B. N. Shobha , N. J. R. Muniraj, Design, modeling and performance analysis of carbon nanotube with DNA strands as biosensor for prostate cancer, Microsyst Technol (2015) 21:791–800, DOI 10.1007/s00542-014-2281-x.

      [19] B.N. Shobha, N.J.R. Muniraj, Modeling and simulation of cntfet for,prostate cancer detection, 30th November 2014. Vol. 69 No.3, ISSN: 1992-8645.

      [20] Carbon Nanotubes: The Hub of Nanoelectronics, P.I. Okwu1 and I.N. Onyeje2, International Journal of Engineering Trends and Technology (IJETT) – Volume 4 Issue 10 - Oct 2013.

      [21] Carbon Nanotubes - A Potential Material for Affinity Biosensors, Vepa K. Rao, S. Suresh, Mukesh K. Sharma, Ajay Gupta and R. Vijayaraghavan Defence Research & Development Establishment, Gwalior, India.

      [22] S. Wind et al, Vertical scaling of carbon nanotube field-effect transistors using top gate electrodes, Appl. Phys. Lett. 80 (20) (2002) 3817–3819.

      [23] Z. Chen et al, The role of metal-nanotube contact in the performance of carbon nanotube field-effect transistors, Nano Lett. 5 (7) (2005) 1497–1502.

  • Downloads

  • How to Cite

    Kumar D. R, S., & P.V. Rao, D. (2018). HPV Sensing by CNTFET Array Nanobiosensor. International Journal of Engineering & Technology, 7(3.34), 82-85. https://doi.org/10.14419/ijet.v7i3.34.18778

    Received date: 2018-09-02

    Accepted date: 2018-09-02

    Published date: 2018-09-01