Green Synthesis of Iron Oxide Nanoparticles (Fe3O4-NPs) using Azadirachta Indica Aqueous Leaf Extract

  • Authors

    • Nurul Izza Taib
    • Famiza Abdul Latif
    • Zakiah Mohamed
    • Nur Diyana Syazwani Zambri
    • . .
    2018-11-27
    https://doi.org/10.14419/ijet.v7i4.18.21811
  • Azadirachta indica, eco-friendly, iron oxide nanoparticles, magnetite, non-toxic.

  • Abstract

    On treatment of aqueous solutions of ferrous and ferric salts in alkaline medium with Azadirachta indica leaf extract, the rapid formation of stable iron oxide nanoparticles (Fe3O4-NPs) or also known as magnetite nanoparticles is observed to occur. In contrast to previously reported co-precipitation approaches, our synthesis method had utilized a much cheaper and less toxic iron precursor with environmentally benign and non-toxic Azadirachta indica leaf extract was used as a reducing and stabilizing agent. It was found that the presence of various biomolecules such as flavonoids and terpenoids of the aqueous leaf extract plays a major role for the formation of Fe3O4-NPs through infrared spectra analysis. The formation was further confirmed with strong characteristic peak observed at 249 nm for Fe3O4-NPs through UV-Vis spectroscopy. Besides, the shape was mostly spherical and oval. X-Ray Diffraction (XRD) analysis revealed the purity of synthesized Fe3O4-NPs with crystalline cubic structure phase.  Transmission Electron Microscopy (TEM) results illustrated that the size and diameter was in the range from 9-14 nm which agrees with calculated Scherrer equation with average diameter of around 11 nm. Vibrating Sample Magnetometer (VSM) analysis indicated that the samples exhibit superparamagnetic with magnetization value was 82 emu/g. Results confirmed this protocol as a simple, rapid, one-step, eco-friendly, non-toxic and hence can be potentially used in various biomedical applications such as magnetic targeting drug delivery system.

     

     

  • References

    1. [1] S. Ahmed, Saifullah, M. Ahmad, B. L. Swami, and S. Ikram, “Green Synthesis of Silver Nanoparticles using Azadirachta Indica Aqueous Leaf Extract,†J. Radiat. Res. Appl. Sci., vol. 9, no. 1, pp. 1–7, 2016.

      [2] H. A. Salam, P. Rajiv, M. Kamaraj, P. Jagadeeswaran, S. Gunalan, and R. Sivaraj, “Plants : Green Route for Nanoparticle Synthesis,†Int. Res. J. Biol. Sci., vol. 1, no. 5, pp. 85–90, 2012.

      [3] L. Tong, M. Zhao, S. Zhu, and J. Chen, “Synthesis and Application of Superparamagnetic Iron Oxide Nanoparticles in Targeted Therapy and Imaging of Cancer,†Front. Med., vol. 5, no. 4, pp. 379–387, 2011.

      [4] S. Laurent, D. Forge, M. Port, a Roch, C. Robic, L. V Elst, and R. N. Muller, “Magnetic Iron Oxide Nanoparticles: Synthesis, Stabilization, Vectorization, Physicochemical Characterizations, and Biological Applications (vol 108, pg 2064, 2008),†Chem. Rev., vol. 108, no. 6, pp. 2064–2110, 2008.

      [5] Q. A. Pankhurst, J. Connolly, J. S. K, and J. Dobson, “Applications of Magnetic Nanoparticles in Biomedicine,†J. Phys. D. Appl. Phys., vol. 36, pp. R167–R181, 2003.

      [6] C. Xu and S. Sun, “New Forms of Superparamagnetic Nanoparticles for Biomedical Applications,†Adv. Drug Deliv. Rev., vol. 65, no. 5, pp. 732–743, 2013.

      [7] S. F. Chin, S. C. Pang, and C. H. Tan, “Green Synthesis of Magnetite Nanoparticles (via Thermal Decomposition Method) with Controllable Size and Shape,†J. Mater. Environ. Sci, vol. 2, no. 3, pp. 299–302, 2011.

      [8] S. Purushotham and R. V. Ramanujan, “Thermoresponsive Magnetic Composite Nanomaterials for Multimodal Cancer Therapy,†Acta Biomater., vol. 6, no. 2, pp. 502–510, 2010.

      [9] M. Mahmoudi, S. Sant, B. Wang, S. Laurent, and T. Sen, “Superparamagnetic Iron Oxide Nanoparticles (Spions): Development, Surface Modification And Applications in Chemotherapy,†Adv. Drug Deliv. Rev., vol. 63, no. 1–2, pp. 24–46, 2011.

      [10] A. H. Lu, E. L. Salabas, and F. Schüth, “Magnetic Nanoparticles: Synthesis, Protection, Functionalization, and Application,†Angew. Chemie - Int. Ed., vol. 46, no. 8, pp. 1222–1244, 2007.

      [11] A. K. Mittal, Y. Chisti, and U. C. Banerjee, “Synthesis of Metallic Nanoparticles using Plant Extracts,†Biotechnol. Adv., vol. 31, no. 2, pp. 346–356, 2013.

      [12] S. Saif, A. Tahir, and Y. Chen, “Green Synthesis of Iron Nanoparticles and Their Environmental Applications and Implications,†Nanomaterials, vol. 6, no. 11, p. 209, 2016.

      [13] P. Mohanpuria, N. K. Rana, and S. K. Yadav, “Biosynthesis of Nanoparticles: Technological Concepts and Future Applications,†J. Nanoparticle Res., vol. 10, no. 3, pp. 507–517, 2008.

      [14] M. Pattanayak and P. L. Nayak, “Ecofriendly Green Synthesis Of Iron Nanoparticles From Various Plants And Spices Extract†Research Foundation and Centre for Excellence in Nano Science and Technology , Synergy Institute of Technology,†Int. J. Plant, Anim. Environ. Sci., vol. 3, no. 1, pp. 68–78, 2012.

      [15] A. C. Larson and R. B. Von Dreele, “General Structure Analysis System,†Los Alamos National Laboratory Report LAUR, 86-748, 2004.

      [16] B. H. Toby, “EXPGUI , A Graphical User Interface for GSAS,†J. Appl. Crystallogr., vol. 34, no. 2, pp. 210–213, 2001.

      [17] K. C. Maheswari and P. S. Reddy, “Green Synthesis of Magnetite Nanoparticles through Leaf Extract of Azadirachta indica,†vol. 2, no. 4, pp. 189–191, 2016.

      [18] A. M. Awwad and N. M. Salem, “A Green and Facile Approach for Synthesis of Magnetite Nanoparticles,†Nanosci. Nanotechnol., vol. 2, no. 6, pp. 208–213, 2013.

      [19] V. S. Zaitsev, D. S. Filimonov, I. A. Presnyakov, R. J. Gambino, and B. Chu, “Physical and Chemical Properties of Magnetite and Magnetite-Polymer Nanoparticles and Their Colloidal Dispersions,†J. Coll. Inter. Sci., vol. 212, pp. 49–57, 1999.

      [20] H. M. Lu, W. T. Zheng, and Q. Jiang, “Saturation Magnetization of Ferromagnetic and Ferrimagnetic Nanocrystals at Room Temperature,†J. Phys. D. Appl. Phys., vol. 40, no. 2, pp. 320–325, 2007.

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  • How to Cite

    Izza Taib, N., Abdul Latif, F., Mohamed, Z., Diyana Syazwani Zambri, N., & ., . (2018). Green Synthesis of Iron Oxide Nanoparticles (Fe3O4-NPs) using Azadirachta Indica Aqueous Leaf Extract. International Journal of Engineering & Technology, 7(4.18), 9-13. https://doi.org/10.14419/ijet.v7i4.18.21811

    Received date: 2018-11-27

    Accepted date: 2018-11-27

    Published date: 2018-11-27