Calcium phosphate nanoparticles prepared via solid-state route

  • Authors

    • A. N. Natasha
    • S. Ramesh
    • C. Y. Tan
    2018-11-27
    https://doi.org/10.14419/ijet.v7i4.18.21826
  • Calcinations, Calcium Phosphate, Eggshell, Synthesis, Solid-state Sintering.
  • To date, the direction of bioceramic research is focused on the improvement of the mechanical performance and biological properties of existing bioactive ceramics particularly HA. Hence, the synthesis of crystalline HA nanoparticles with expected microstructure is of   primary importance because the process directly relates to the phase purity, morphology, and particle size of the final HA particles. In this work, a simple and cost-effective technique, solid state reaction method was successfully employed to synthesize highly crystalline, high purity and single phase nanostructured hydroxyapatite powder using waste eggshells (HA-Es). The process involved mixing calcined eggshell powder and dicalcium hydrogen phosphate di-hydrate followed by a heat treatment at 800 °C for 5 hours. The resultant flower-like nanostructure HA powder is composed of leaf-like flakes having 100-200 nm width and crystallite size calculated using XRD data of ~56.21 nm.

     

  • References

    1. [1] Abdulrahman I, Tijani HI, Mohammed BA, Saidu H, Yusuf, H, Jibrin MN & Mohammed S (2014), From garbage to biomaterials: an overview on eggshell based hydroxyapatite. Journal of Materials 2014, 1-6.

      [2] Ho WF, Hsu HC, Hsu SK, Hung CW & Wu SC (2013), Calcium phosphate bioceramics synthesized from eggshell powders through a solid state reaction. Ceramics International 39, 6467–6473.

      [3] Wu SC, Hsu HC, Hsu SK, Chang YC & Ho WF (2011), Effects of heat treatment on the synthesis of hydroxyapatite from eggshell powders. Ceramics International, 1–7.

      [4] Bahrololoom ME, Javidi M, Javadpour S & Ma J (2009). Characterisation of natural hydroxyapatite extracted from bovine cortical bone ash. Journals of Ceramic Processing Research 10, 129-138.

      [5] Sadat-Shojai M, Khorasani MT, Dinpanah-Khoshdargi E & Jamshidi A (2013), Synthesis methods for nanosized hydroxyapatite with diverse structures. Acta Biomaterialia 9, 7591–7621.

      [6] Krishna DSR, Siddharthan A, Seshadri SK & Kumar TS. (2007), A novel route for synthesis of nanocrystalline hydroxyapatite from eggshell waste. Journal of Materials Science: Materials in Medicine 18, 1735-1743.

      [7] Ruksudjarit A, Pengpat K, Rujijanagul G & Tunkasiri T (2008), Synthesis and characterization of nanocrystalline hydroxyapatite from natural bovine bone. Current Applied Physics 8, 270–272.

      [8] Kumar GS, Thamizhavel A & Girija EK (2012), Microwave conversion of eggshells into flower-like hydroxyapatite nanostructure for biomedical applications. Materials Letters 76, 198–200.

      [9] Landi E, Uggeri J, Sprio S, Tampieri A & Guizzardi S (2010), Human osteoblast behavior on asâ€synthesized SiO4 and Bâ€CO3 coâ€substituted apatite. Journal of Biomedical Materials Research Part A 94, 59-70.

      [10] Bang LT, Ramesh S, Purbolaksono J, Ching YC, Long BD, Chandran H & Othman R (2015), Effects of silicate and carbonate substitution on the properties of hydroxyapatite prepared by aqueous co-precipitation method. Materials & Design 87, 788-796.

      [11] Dorozhkin SV (2010), Nanosized and nanocrystalline calcium orthophosphates. Acta Biomaterialia 6, 715–734.

      [12] Gross KA & Rodríguez-Lorenzo LM (2004), Sintered hydroxyfluorapatites. Part I: Sintering ability of precipitated solid solution powders. Biomaterials 25, 1375–1384.

      [13] Yeong KCB, Wang J & Ng SC (2001), Mechanochemical synthesis of nanocrystalline hydroxyapatite from CaO and CaHPO4. Biomaterials 22, 2705–2712.

      [14] Prabakaran K, Balamurugan A & Rajeswari S (2005), Development of calcium phosphate based apatite from hen’s eggshell. Bulletin of Materials Science 28, 115–119.

      [15] Ramesh S, Natasha AN, Tan CY, Bang AT, Niakan A, Purbolaksono J, Hari Chandran, Ching CY & Teng WD (2015), Characteristics and properties of hydroxyapatite derived by sol–gel and wet chemical precipitation methods. Ceramics International 41, 10434-10441.

      [16] Raynaud S, Champion E, Bernache-Assollant D & Thomas P (2002), Calcium phosphate apatites with variable Ca/P atomic ratio I. Synthesis, characterisation and thermal stability of powders. Biomaterials 23, 1065–1072.

      [17] Ng S, Guo J, Ma J & Loo SCJ (2010), Synthesis of high surface area mesostructured calcium phosphate particles. Acta Biomaterialia 6, 3772–3781.

      [18] Guo X, Yan H, Zhao S, Li Z, Li Y & Liang X (2013), Effect of calcining temperature on particle size of hydroxyapatite synthesized by solid-state reaction at room temperature. Advanced Powder Technology 24, 1034–1038.

      [19] Pramanik S, Agarwal AK, Rai KN & Garg A (2007), Development of high strength hydroxyapatite by solid-state-sintering process. Ceramics International 33, 419–426.

      [20] Koutsopoulos S (2002), Synthesis and characterization of hydroxyapatite crystals: A review study on the analytical methods. Journal of Biomedical Material Research 62, 600-612.

      [21] Kamalanathan P, Ramesh S, Bang LT, Niakan A, Tan CY, Purbolaksono J, Chandran H & Teng WD (2014), Synthesis and sintering of hydroxyapatite derived from eggshells as a calcium precursor. Ceramics International 40, 16349–16359.

      [22] Gergely G, Weber F, Lukacs I, Illes L, Toth AL, Horvath ZE, Mihaly J & Balazsi C (2010), Nano-hydroxyapatite preparation from biogenic raw materials. Central European Journal of Chemistry 8, 375–381.

      [23] Boanini E, Gazzano M & Bigi A (2010), Ionic substitutions in calcium phosphates synthesized at low temperature. Acta Biomaterialia 6, 1882–1894.

      [24] Ferkel H, & Hellmig RJ (1999), Effect of nanopowder deagglomeration on the densities of nanocrystalline ceramic green bodies and their sintering behaviour. Nanostructured Materials 11, 617-622.

      [25] Zanotto A, Saladino ML, Martino DC & Caponetti E (2012), Influence of temperature on calcium hydroxyapatite nanopowders. Advances in Nanoparticles 01, 21–28.

      [26] Ramesh S, Natasha AN, Tan CY, Bang LT, Ching CY, Ramesh S & Hari Chandran (2016), Direct conversion of eggshell to hydroxyapatite ceramic by a sintering method. Ceramics International 42, 7824-7829.

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    N. Natasha, A., Ramesh, S., & Y. Tan, C. (2018). Calcium phosphate nanoparticles prepared via solid-state route. International Journal of Engineering & Technology, 7(4.18), 80-83. https://doi.org/10.14419/ijet.v7i4.18.21826