Alpha Lactose Monohydrate Morphology: Molecular Modelling and Experimental Approach

  • Authors

    • Zulfahmi Lukman
    • Nornizar Anuar
    • Noor Fitrah Abu Bakar
    • Norazah Abdul Rahman
    2018-11-27
    https://doi.org/10.14419/ijet.v7i4.18.21832
  • hydrogen bond, lattice energy molecular modelling, surface chemistry.

  • This study is conducted to investigate morphologies ofalpha lactose monohydrate (αLM) grown in polyethylene glycol 300 (PEG 300) solution and vacuum condition via molecular modelling techniques. Surface chemistry of predicted αLM is described. The molecules of αLM in its unit lattice were optimized prior to morphological prediction of attachment energy method and the suitable potential function was determined. The predicted lattice energy of αLM was in excellent agreement with the experimental lattice energy with percent errors of 3.9%. The morphology of αLM is predicted to be hexagonal in shape, similar to crystal morphology of αLM grown in PEG 300 solutions. It was found that the lattice energy and of αLM was dominated by the weak van der Waals force.

     

     

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    Lukman, Z., Anuar, N., Fitrah Abu Bakar, N., & Abdul Rahman, N. (2018). Alpha Lactose Monohydrate Morphology: Molecular Modelling and Experimental Approach. International Journal of Engineering & Technology, 7(4.18), 107-112. https://doi.org/10.14419/ijet.v7i4.18.21832