Near-Infrared Spectroscopy (NIRS)-based Digit Skin Tissue Blood Flow Measurement System
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2018-11-30 https://doi.org/10.14419/ijet.v7i4.30.22076 -
, Arduino, Digit Skin Tissue Blood Flow, MATLAB, Modified Lambert-Beer Law, NIRS -
Abstract
The tissue blood flow (BF) and vascular resistance are the important information for consult peripheral vascular system which related to cardiovascular disease. Unfortunately, most of the current BF monitors are costly, built in huge size and preferable use in hospital and clinic. In the present study, a portable digit skin tissue BF measurement system had been developed using Near-infrared spectroscopy (NIRS) method with simple circuitry and low cost that can be afforded by patients to monitor their cardiovascular information. This system consists of a self-developed NIRS probe; LED and a photodiode, and an Arduino Uno board with MATLAB software as the processing unit. The NIR LED transmits 810 nm light source through biological tissue then detected by the photodiode. The output signal from the NIRS probe is based on resistance changes in the photodiode and by applying the voltage divider law, the signal is further processed by the Arduino with the MATLAB software. Then, according to the modified Lambert-Beer Law in scattering medium, the change in total concentration of haemoglobin ( ) is plotted in order to get a quantitative BF reading which based on its maximum change during venous occlusion. To evaluate the proposed BF measurement system, BF measurement tests had been conducted on four healthy subjects during resting and after exercise. The study had shown that the results of BF after the exercise were in average of 1.5 time higher than the resting BF and this finding agrees with previous research works.
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References
[1] Elwell C, A Practical User Guide to Near Infrared Spectroscopy. 1st edition, London: Hamatsu Phototonics KK, (1995).
[2] Jöbsis FF (1977), Noninvasive Infrared Monitoring of Cerebral and Myocardial Oxygen Sufficiency and Circulatory Parameters. Science 198 (4323), 1264-1267.
[3] Burns & Donald A, Handbook of Near-infrared Analysis. 3rd edition, Boca Raton: CRC Press, (2008).
[4] Huong A, Philimon S & Ngu X (2017), Multispectral Imaging of Acute Wound Tissue Oxygenation. J. Innov. Opt. Health Sci. 10, 1750004.
[5] Ong P, Huong AK, Hafizah W, Tay K & Philimon SP (2016), Reflectance Spectroscopy System for Noninvasive Prediction of Skin Bilirubin Concentration Related Parameter, 2016 IEEE EMBS Conference in Biomedical Engineering and Sciences (IECBES), 352-355.
[6] Nimmo S & Tucker G, Assessment of the effects of drugs on the peripheral vasculature, Clinical Measurement in Drug Evaluation, London: John Wiley & Sons Ltd., (1995), 136-150.
[7] Wright CI & Draijer R (2006), Non-invasive Methods and Stimuli for Evaluating the Skin's Microcirculation. J Pharmacol Toxicol Methods 54 (1), 1-25.
[8] Mireille CPVB, Willy NJMC, Ron AW & Baziel GMVE (2001), Performance of near-infrared spectroscopy in measuring Local O2 consumption and blood flow in skeletal muscle. J Appl Physiol. 90(2), 511-519.
[9] Farhanahani Mahmud, Portable Blood Flow Monitor based on Near-Infrared Spectroscopy: An Application of H8/3694F Microcontroller. Master Thesis of Electrical and Electronic Systems Engineering, University of Toyama, (2008).
[10] Steen JM, Optical Methods and Instrumentation in Brain Imaging and Therapy, Springer Science, (2013), 34-35.
[11] Strangman G, Franceschini MA & Boas DA (2003), Factors Affecting the Accuracy of Near-Infrared Spectroscopy Concentration Calculations for Focal Changes in Oxygenation Parameters. NeuroImage 18, 865-879.
[12] Scholkmann F & Wolf M (2013), General Equation for the Differential pathlength Factor of the Frontal Human Head Depending on Wavelength and Age. J. Biomed Opt. 18(10), 105004.
[13] Bakker A, Smith B, Ainslie P & Smith K, Near-Infrared Spectroscopy, Applied Aspects of Ultrasonography in Humans, InTechOpen, (2012), 65-74.
[14] Chatel B, Bendahan D & Jue T, Hemoglobin and Myoglobin Contribution to the NIRS Signals in Skeletal Muscle, Modern Tools of Biophysics. Handbook of Modern Biophysics, vol. 5, Springer, (2017), 109-117.
[15] Wray et al. (1988), Characterization of the Near Infrared Absorption Spectra of Cytochrome aa3 and Haemoglobin for the Non-Invasive Monitoring of Cerebral Oxygenation. Biochem. Biophys. Acta. 933, 184-192.
[16] Chance B (1994), Current State of Methodology on Haemoglobin Oximetry in Tissues. Adv Exp Med Biol., 345, 23-32.
[17] Gibney et al. (2010), Skin and Subcutaneous Adipose Layer in Adults with Diabetes at Sites Used for Insulin Injections: Implications for Needle Length Recommendations. Current Medical Research & Opinion 26 (6), 1519-1530.
[18] Elwell MR, Stedman CA, Kovatch RM, Skin and Subcutis, Pathology of the Fischer Rat. Reference and Atlas, Academic Press, (1990), 261-277.
[19] Ruckman JS, A Comparative Study of Total Hemoglobin Measurement Technology: Noninvasive Pulse Oximetry and Conventional Methods, Master Thesis, University of Connecticut, (2011).
[20] Soldin OP & Mattison DR (2009), Sex Differences in Pharmacokinetics and Pharmacodynamics. Clin Pharmacokinet. 48(3), 143-157.
[21] Jamil Mayet & Alun Hughes (2003), Cardiac and Vascular Pathophysiology in Hypertension. Heart 89(9), 1104-1109.
[22] Gao Y, Biology of Vascular Smooth Muscle: Vasoconstriction and Dilatation, China: Springer, (2017).
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How to Cite
Yin, T. Y., Mahmud, F., & Ramli, N. I. (2018). Near-Infrared Spectroscopy (NIRS)-based Digit Skin Tissue Blood Flow Measurement System. International Journal of Engineering & Technology, 7(4.30), 131-135. https://doi.org/10.14419/ijet.v7i4.30.22076Received date: 2018-11-28
Accepted date: 2018-11-28
Published date: 2018-11-30