Formation of New Ligands Imine- (Oxazole, Thiazole, Thiophene) And Study of (Chemical Investigation and Chromatographic Applications)

  • Authors

    • Mostafa N. Mohamed Salih
    • Zaid Noor ObaidAl-Husseini
    • Nagham Mahmood Aljamali
    2018-12-09
    https://doi.org/10.14419/ijet.v7i4.36.24204
  • React, derivative, form.
  • Abstract

    (Oxazole, Thiazole, Thiophene) derivatives- Imine ligands were synthesized in this paper by using  many  reactions such as cyclization  reaction,  chalcone  reaction  in  basic  medium, condensation  reaction  to format four new ligands included heterocycles represented by oxazole, thiophene, thiazole derivatives with imine group in same compounds. The four ligands have been identified by several methods such as spectra of (UV-Visible investigation, 1H NMR, FT.IR) and study of chromatographic applications for all ligands.

     

  • References

    1. [1] Young RW & Wood KH, “The Cyclization of 3-Acyldithiocarbazate Esters1â€, Journal of the American Chemical Society, Vol.77, No.2, (1955), pp.400-403.

      [2] Chen H, Li Z & Han Y, “Synthesis and Fungicidal Activity against Rhizoctoniasolani of 2-Alkyl (Alkylthio)-5-pyrazolyl-1, 3, 4-oxadiazoles (Thiadiazoles)â€, Journal of agricultural and food chemistry, Vol.48, No.11, (2000), pp.5312-5315.

      [3] Bauer AW,Kirbay WAW,Sherris JS& Turk M, “Antibiotic susceptibility testing by a standardized single disc methodâ€, American Journal Clinical Pathology, Vol.45, No.4, (1996), pp.493-496.

      [4] Filali Baba Y, Elmsellem H, KandriRodi Y, Steli H, AD5 C, Ouzidan Y,OuazzaniChahdi F, Sebbar NK, EssassiEM &Hammouti B,Der PharmChemica, Vol.8, No.4,(2016), pp.159-169.

      [5] Kiran MK, Sagar AJ, Pramod BP, Vikas RDSSP, Der PharmaChemica, Vol.8, No.4,(2016), pp.1-5.

      [6] Chao SJ, Hui XP, Li S, Qiu ZZ, Xu PF, Zhang ZY & Guan ZW, “Synthesis and Antibacterial Activities of Novel Biphenyltetrazole Derivatives Bearing 1, 3, 4â€Oxadiazoleâ€, Journal of the Chinese Chemical Society, Vol.52, No.3, (2005), pp.539-544.

      [7] Srinivas K, Srinivas U, Bhanuprakash K, Harakishore K, Murthy USN &Rao VJ, “Synthesis and antibacterial activity of various substituted s-triazinesâ€, European journal of medicinal chemistry, Vol.41, No.11, (2006), pp.1240-1246.

      [8] Tripathi KD, “Antihypertensive drugsâ€, Essentials of Medical Pharmacology, 6th ed. New Delhi: Jaypee Brothers Medical Publishers, (2008), pp.539-43.

      [9] AateshÈznur K, “CesurNesrin, Synthesis and antimicrobial activity of some 5-aryl-2-[(N, N-disubstitutedthiocarbamoylthio) acylamino]-1, 3, 4-oxadiazolesâ€, Farmaco, Vol.53, (1998), pp.541-544.

      [10] Montalbetti CA &Falque V, “Amide bond formation and peptide couplingâ€, Tetrahedron, Vol.61, No.46, (2005), pp.10827-10852.

      [11] Nagham M Aljamali, “Synthesis, Investigation, Chromatography, Thermal-Behavior of (Five, Seven)-Membered Ring With Azo and Anil Compounds. Pak. J. Biotechnol., Vol.15, No.1, (2018), pp.225-237.

      [12] Nanjunda S, Swamy S, Basppa PB, Prabhuswamy B &Doreswamy BH, “Crystal Structure of Novel 2-butyl-4-chloro-1HImidazolyl-5-Carboxaldehydeâ€, European Journal. of Medicinal Chemistry, Vol.41, (2006), pp.531-538.

      [13] Jin L, Chen J, Song B, Chen Z, Yang S, Li Q &Xu R, “Synthesis, structure, and bioactivity of N′-substituted benzylidene-3, 4, 5-trimethoxybenzohydrazide and 3-acetyl-2-substituted phenyl-5- (3, 4, 5-trimethoxyphenyl)-2, 3-dihydro-1, 3, 4-oxadiazole derivativesâ€, Bioorganic & Medicinal Chemistry Letters, Vol.16, No.19, (2006), pp.5036-5040.

      [14] Aboraia AS, Abdel-Rahman HM, Mahfouz NM & El-Gendy MA, “Novel 5-(2-hydroxyphenyl)-3-substituted-2, 3-dihydro-1, 3, 4-oxadiazole-2-thione derivatives: promising anticancer agentsâ€, Bioorganic & medicinal chemistry, Vol.14, No.4, (2006), pp.1236-1246.

      [15] Nagham M Aljamali.,“Preparation, Spectral Investigation, Thermal Analysis, Biochemical Studying of New (Oxadiazole-Five Membered Ring)-Ligandsâ€, Journal of Global Pharma Technology, Vol.10, No.1, (2018), pp.20-29.

      [16] Uribe-Romo FJ, Hunt JR, Furukawa H, Klock C, O’Keeffe M &Yaghi OM, “A crystalline imine-linked 3-D porous covalent organic frameworkâ€, Journal of the American Chemical Society, Vol.131, No.13, (2009), pp.4570-4571.

      [17] Hathaway B&Billing DE, “The electronic properties and stereochemistry of mono-nuclear complexes of the copper (II) ionâ€, Coordination Chemistry Reviews, Vol.5, No.2, (1970), pp.143-207.

      [18] Singh RV, Dwivedi R & Joshi SC, “Synthetic, magnetic, spectral, antimicrobial and antifertility studies of dioxomolybdenum (VI) unsymmetrical imine complexes having a N∩ N donor systemâ€, Transition Metal Chemistry, Vol.29, No.1, (2004), pp70-74.

      [19]

      Nagham M Aljamali&Alfatlawi IO, “Synthesis of sulfur heterocyclic compounds and study of expected biological activityâ€, Research Journal of Pharmacy and Technology, Vol.8, No.9, (2015), pp.1225-1242.

      [20] Mohammed M, Nagham M Aljamali, Abdalrahman SA &Shubber WA, “Formation of Oxadiazole Derivatives Ligands From Condensation and Imination Reaction With Reference to Spectral Investigation, Thermal And Microbial Assayâ€, Biochem. Cell. Arch., Vol.18, No.1, (2018), pp.847-853.

      [21] Nozaki H, Takaya H, Moriuti S &Noyori R, “Homogeneous catalysis in the decomposition of diazo compounds by copper chelates: Asymmetric carbenoid reactionsâ€, Tetrahedron, Vol.24, No.9, (1968), pp.3655-3669.

      [22] Hindson JC, Ulgut B, Friend RH, Greenham NC, Norder B, Kotlewski A &Dingemans TJ, “All-aromatic liquid crystal triphenylamine-based poly (azomethine) s as hole transport materials for opto-electronic applicationsâ€, Journal of Materials Chemistry, Vol.20, No.5, (2010), pp.937-944.

      [23] Cremlyn RJW, An introduction to organosulfur chemistry, John Wiley & Sons Inc, (1996).

      [24] GarcíaRuano JL, Cid MB, Martín Castro AM &Alemán J, “Acyclic S, S-Dialkylsulfimidesâ€, Kambe, N. Science of Synthesis, Vol.39, (2008), pp.352-375.

      [25] Nagham M Aljamali, Saher M J, Zainab M J&Alfatlawi IO, “Inhibition Activity of (Azo–Acetyl acetone) on Bacteria of Mouthâ€, Research J. Pharm. and Tech, Vol.10, No.6, (2017), pp.1683-1686.

      [26] Drabowicz J, Lewkowski J, Kudelska W &Girek T, “S-Dialkylsulfoximidesâ€, Kambe, N. Science of Synthesis, Vol.39, (2008), pp.154-173.

      [27] Drabowicz J, Lewkowski J, Kudelska W &Girek, T, “S-Dialkylsulfonediiminesâ€, Kambe, N. Science of Synthesis, Vol.39, (2008), pp.173-180.

      [28] Zhang Y& Hogg N, “S-Nitrosothiols: cellular formation and transportâ€, Free radical biology and medicine, Vol.38, No.7, (2005), pp.831-838.

      [29] Nagham M Aljamali, “Synthesis of New Organic Compounds Via Three Components Reaction with Studying of (Identification, Thermal Behavior, Bioactivity on Bacteria of Teeth)â€, Journal of Global Pharma Technology, Vol.11, No.9, (2018), pp.157-164.

      [30] Braverman S, Cherkinsky M &Levinger S, “AlkylsulfurTrihalidesâ€, In Kambe, N. Science of SynthesisThieme., Vol.39, (2008), pp.187–188.

      [31] Drabowicz J, Lewkowski J, Kudelska W &Girek T, “Dialkylsulfur Tetrahalidesâ€, In Kambe, N. Science of Synthesis Thieme., Vol.39, (2008), pp.123–124.

      [32] Arora P, Arora V, Lamba HS &Wadhwa D, “Importance of Heterocyclic Chemistry: A Reviewâ€, Int J Pharm Res Sci., Vol.3, No.9, (2012), pp.2947-2955.

      [33] Nagham M Aljamali&Rahi D, “New Formazan Compounds (Synthesis, Identification, Physical Properties)â€, Journal of Chemical and Pharmaceutical Sciences, Vol.10, No.3, (2017), pp.1461-1472.

      [34] Sreedaran S, Bharathi KS, Rahiman AK, Rajesh K, Nirmala G, Jagadish L & Narayanan V, “Synthesis, electrochemical, catalytic and antimicrobial activities of novel unsymmetrical macrocyclicdicompartmental binuclear nickel (II) complexesâ€, Polyhedron, Vol.27, No.7, (2008), pp.1867-1874.

      [35] Eman HS &Nagham M Aljamali, “New Azo-Thiadiazole Ligands (Preparation, Spectral, Thermal, Biochemical, Physical properties)-Studyingâ€, Journal of Global Pharma Technology, Vol.11, No.9, (2017), pp.165-173.

      [36] Nakamoto K, “Infrared and R aman Spectra of Inorganic and Coordination Compoundsâ€, Handbook of Vibrational Spectroscopy, (2006).

      [37] Schneider I, Keuleyan E, Rasshofer R, Markovska R, Queenan AM &Bauernfeind A, “VIM-15 and VIM-16, two new VIM-2-like metallo-β-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germanyâ€, Antimicrobial agents and chemotherapy, Vol.52, No.8, (2008), pp.2977-2979.

      [38] Bogaerts P, Bauraing C, Deplano A &Glupczynski Y, “Emergence and dissemination of BEL-1-producing Pseudomonas aeruginosa isolates in Belgiumâ€, Antimicrobial agents and chemotherapy, Vol.51, No.4, (2007), pp.1584-1585.

  • Downloads

  • How to Cite

    N. Mohamed Salih, M., Noor ObaidAl-Husseini, Z., & Mahmood Aljamali, N. (2018). Formation of New Ligands Imine- (Oxazole, Thiazole, Thiophene) And Study of (Chemical Investigation and Chromatographic Applications). International Journal of Engineering & Technology, 7(4.36), 580-585. https://doi.org/10.14419/ijet.v7i4.36.24204

    Received date: 2018-12-18

    Accepted date: 2018-12-18

    Published date: 2018-12-09