Synthesis and Spectral Studies of Novel Palladium (O) Complex with Ciprofloxacin Antibiotic

  • Authors

    • N. S. Majeed
    • I. K. Kareem
    • N. N.A. Jafar
    2018-12-09
    https://doi.org/10.14419/ijet.v7i4.36.24230
  • Spectral studies, palladium complex, ciprofloxacin, elemental analysis.

  • Abstract

    New complex of Palladium (0) with ciprofloxacin has been synthesized, The complex was portrayed by different physico - substance systems like essential examination, m.pt. , TLC, molar conductance estimation, attractive helplessness,13C- NMR, 1H-NMR and FT-IR. According to the results obtained, tetrahedral structure suggested for the prepared complex. The neutral ligand act in a Didentate mode, binding through oxygen atom of carbonyl group in pyridonering and oxygen atom of carboxyl ate group.

     

     

  • References

    1. [1] Mertindale W, Martindale – the extra Pharmacopeia, 30thed, the Pharmaceutical Press, London, (1993).

      [2] Turel I, GolobiÄ A, Klavžar A, Pihlar B, Buglyo P, Tolis E & SepÄić K, “Interactions of oxovanadium (IV) and the quinolone family member—ciprofloxacinâ€, Journal of inorganic biochemistry, Vol.95, No.2, (2003), pp.199-207.

      [3] Serafin A & Staczak A, “Russian Journal of Coordination Chemistryâ€, Springer, Vol.35, No.2, (2009), pp.83-97.

      [4] Anacona JR & Toledo C, “Synthesis and antibacterial activity of metal complexes of ciprofloxacinâ€, Transition Metal Chemistry, Vol.26, No.1-2, (2001), pp.228-231.

      [5] Psomas G, “Mononuclear metal complexes with ciprofloxacin: synthesis, characterization and DNA-binding propertiesâ€, Journal of inorganic biochemistry, Vol.102, No.9, (2008), pp1798-1811.

      [6] Delaney S, Pascaly M, Bhattacharya PK, Han K & Barton JK, “Oxidative damage by ruthenium complexes containing the dipyridophenazine ligand or its derivatives: a focus on intercalationâ€, Inorganic chemistry, Vol.41, No.7, (2002), pp.1966-1974.

      [7] Kara M, Hasinoff BB, McKay DW & Campbell NR, “Clinical and chemical interactions between iron preparations and ciprofloxacinâ€, British journal of clinical pharmacology, Vol.31, No.3, (1991), pp.257-261.

      [8] Ball P, “Quinolone generations: natural history or natural selection?â€, Journal of Antimicrobial Chemotherapy, Vol.46, No.3, (2000), pp.17-24.

      [9] Turel I, “The Interactions of metal ions with quinolone Antibacterial Agentsâ€, Coordination Chemistry Reviews, Vol.232, No.1-2, (2002), pp.27-47.

      [10] Vieira LMM, De Almeida MV, De Abreu HA, Duarte HA, Grazul RM & Fontes APS, “Platinum (II) complexes with fluoroquinolones: Synthesis and characterization of unusual metal–piperazine chelatesâ€, Inorganica Chimica Acta, Vol.362, No.6, (2009), pp.2060-2064.

      [11] Rusu A, Tóth G, SzÅ‘cs L, Kökösi J, Kraszni M, Gyéresi à & Noszál B, “Triprotic site-specific acid–base equilibria and related properties of fluoroquinolone antibacterialsâ€, Journal of pharmaceutical and biomedical analysis, Vol.66, (2012), pp.50-57.

      [12] Siddiqi ZA, Khalid M, Kumar S, Shahid M & Noor S, “Antimicrobial and SOD activities of novel transition metal complexes of pyridine-2, 6-dicarboxylic acid containing 4-picoline as auxiliary ligandâ€, European journal of medicinal chemistry, Vol.45, No.1, (2010), pp.264-269.

      [13] Liu YC, Chen ZF, Shi SM, Luo HS, Zhong DC, Zou HL & Liang H, “Synthesis, crystal structure of polyoxovanadate complex of ciprofloxacin: V4O10(μ2-O)2 [VO(H-Ciprof)2]2·13H2O by hydrothermal reactionâ€, Inorganic Chemistry Communications, Vol.10, No.11, (2007), pp.1269-1272.

      [14] Negishi E, Handbook of Organ palladium Chemistry for Organic Synthesis, Wiley-Inter science: New York, (2002).

      [15] Tsuji J, Palladium in Organic Synthesis, Springer: Berlin, (2005).

      [16] Li J & Gribble GW, Palladium in Heterocyclic Chemistry, Pergamon: New York, (2000).

      [17] Jafar NN & Majeed NS, “Microwave-assisted synthesis and biological activity of ester, carbothioate and carbohydrazide derivative compounds of the drug Ciprofloxacinâ€, J. Chem. Pharmaceut. Sci., Vol.10, (2017), pp.515-521.

      [18] Nakamoto K, Infrared spectra of inorganic and coordination compounds. 2nded. New York: Wiley Inter science, (1970).

      [19] Ferraro JR, Low frequency vibrations of inorganic and coordination compounds. 2nded. New York: John Wiley, (1971).

      [20] Kothari R, Sharma B, Sahawal S, Neha K, Mandal S, Birthare S & Shivhare V, “Synthesis, Characterization And Antimicrobial Evaluation of Copper (Ii) Complex with Ciprofloxacin Antibioticâ€, World Journal of Pharmacy and Pharmaceutical Sciences, Vol.4, No.6, (2015), pp.696-707.

  • Downloads

  • How to Cite

    S. Majeed, N., K. Kareem, I., & N.A. Jafar, N. (2018). Synthesis and Spectral Studies of Novel Palladium (O) Complex with Ciprofloxacin Antibiotic. International Journal of Engineering & Technology, 7(4.36), 722-724. https://doi.org/10.14419/ijet.v7i4.36.24230

    Received date: 2018-12-18

    Accepted date: 2018-12-18

    Published date: 2018-12-09