Anti-Acetylcholinesterase, Anti-Inflammatory and Anti-Oxidant Activities of Raw-Extract Centella Asiatica (RECA) on Lipopolysaccharide (LPS)-Induced Neuroinflammation Sprague Dawley Rats

  • Authors

    • Z Hafiz
    • N Shamsuddin
    • S M Mukhtar
    • R J James
    • M I Adenan
    2019-12-24
    https://doi.org/10.14419/ijet.v7i4.14.27479
  • Acetylcholinesterase inhibition, anti-inflammatory, anti-oxidant, lipopolysaccharide (LPS), raw-extract Centella asiatica (RECA).

  • The present study was designed to investigate the potential of raw-extract of Centella asiatica (RECA) in suppressing acetylcholinesterase (AChE), inflammations and oxidative stress via induction of lipopolysaccharide (LPS) on animal model of Sprague Dawley rats. Centella asiatica is a plant that has been used as a traditional herbal remedy for the management of several diseases, including memory improvement, treatment of mental fatigue and wound healing. Pre-treatment with RECA in vitro significantly reduced the AChE activity in a concentration-dependent manner with IC50 value of 57.47 ± 13.55 µg/ml. Interestingly, this result was parallel with in vivo studies. Moreover, the level of pro-inflammatory cytokines and oxidative stress were significantly reduced by RECA in dose-dependent manner. Overall, our findings clearly dictate the potential of RECA as AChE inhibitor as well anti-inflammatory and anti-oxidant agents.

     

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    Hafiz, Z., Shamsuddin, N., M Mukhtar, S., J James, R., & I Adenan, M. (2019). Anti-Acetylcholinesterase, Anti-Inflammatory and Anti-Oxidant Activities of Raw-Extract Centella Asiatica (RECA) on Lipopolysaccharide (LPS)-Induced Neuroinflammation Sprague Dawley Rats. International Journal of Engineering & Technology, 7(4.14), 96-101. https://doi.org/10.14419/ijet.v7i4.14.27479