Effect of Flow Behavior on the Production of PVA/Dextrin Microspheres

  • Authors

    • Nizar Jawad Hadi
    • Auda Jabbar Braihi
    • Sara Kareem Mohammed
    2018-11-27
    https://doi.org/10.14419/ijet.v7i4.19.27979
  • Bio-polymer, Flow behavior, Microspheres, Shear thinning, Stability.
  • Abstract

    This work studies the production of microspheres from biopolymer towards using  as drug carrier and elucidation of the effect of flow behavior on the properties of microspheres. Poly(vinyl alcohol) PVA of 2, 2.5, 3 wt%  was mixed with 18% Dextrin using sonication process and then stirred for 20 h at 5°C. Different samples were taken after 4, 8, 12, 16, and 20 hr during stirring process for each concentration. Optical Microscopy, Zeta potential and AFM were used to check the size, shape, distribution, and stability of microspheres at rest. Dynamic viscosity and shear stress of the samples were tested under (0.1-50) s-1shear rates at 37oC in vivo condition by using con-plate viscometer. The result show that the microspheres were formed in spherical shape in sizes up to 150 micrometers and the increasing of PVA concentration lead to the increasing of wall microsphere thickness. The first concentration have incipient instability and moderate stability for the second and third concentrations. Also, the viscosity curve exhibited non-Newtonian flow and shear thinning behavior at 2, 2.5 and 3 wt% PVA/Dextrin emulsion. The microspheres deformed at 50 s-1 shear rate for the first concentration. The microspheres keep stable in the second and third concentration due to the gradually shear thinning effect. The stability of microspheres of third concentration was higher than others at rest and dynamic test. A good agreement occurs between viscosity behavior and the microspheres characteristics and stability.

     

     


  • References

    1. [1] Elfstrand, Lidia, Annâ€Charlotte Eliasson, and Marie Wahlgren. "The effect of starch material, encapsulated protein and production conditions on the protein release from starch microspheres." Journal of pharmaceutical sciences 98.10 (2009): 3802-3815.â€

      [2] Ramteke, K. H., V. B. Jadhav, and S. N. Dhole. "Microspheres: as carrieres used for novel drug delivery system." IOSRPHR 2.4 (2012): 44-48.â€

      [3] Woo, Byung H., et al. "Preparation and characterization of a composite PLGA and poly (acryloylhydroxyethyl starch) microsphere system for protein delivery." Pharmaceutical research 18.11 (2001): 1600-1606.â€

      [4] Alagusundaram, M., et al. "Microspheres as a novel drug delivery system-a review." Int J Chem Tech Res 1.3 (2009): 526-534.â€

      [5] Patel, Nirav R., et al. "Microsphere as a novel drug delivery." International Journal of Pharmacy & Life Sciences 2.8 (2011).â€

      [6] Woo, Byung H., et al. "Preparation and characterization of a composite PLGA and poly (acryloyl hydroxyethyl starch) microsphere system for protein delivery." Pharmaceutical research 18.11 (2001): 1600-1606.â€

      [7] Capan, Yilmaz, et al. "Preparation and characterization of poly (D, L-lactide-co-glycolide) microspheres for controlled release of human growth hormone." AAPS PharmSciTech 4.2 (2003): 147-156.â€

      [8] [Thanoo, B. Chithambara, M. C. Sunny, and A. Jayakrishnan. "Crossâ€linked Chitosan microspheres: preparation and evaluation as a matrix for the controlled release of pharmaceuticals." Journal of Pharmacy and Pharmacology 44.4 (1992): 283-286.â€

      [9] Khare, Piush, and Sanjay K. Jain. "Influence of rheology of dispersion media in the preparation of polymeric microspheres through emulsification method." AAPS PharmSciTech 10.4 (2009): 1295-1300.â€

      [10] Bhardwaj, Tilak R., et al. "Natural gums and modified natural gums as sustained-release carriers." Drug development and industrial pharmacy 26.10 (2000): 1025-1038.

      [11] Gohel, M. C., and Avani F. Amin. "Formulation optimization of controlled release diclofenac sodium microspheres using factorial design." Journal of Controlled Release 51.2-3 (1998): 115-122.â€

      [12] Srivastava, Shalini, and Pritee Goyal. Novel biomaterials: decontamination of toxic metals from wastewater. Springer Science & Business Media, (2010).â€

      [13] Ramana, G., M. Sushma, and Y. Arun. "Formulation and Evaluation of Sustained Release Bilayer Tablets of Ambroxol Hydrochloride." International Journal of Innovative Pharmaceutical Research 1.3 (2010): 61-65.â€

      [14] Chattopadhyay, Helen, Amit Kumar De, and Sriparna Datta. "Novel starch-PVA polymer for microparticle preparation and optimization using factorial design study." International scholarly research notices 2015 (2015).â€

      [15] Singh, Akhilesh V., Lila K. Nath, and Anudwipa Singh. "Pharmaceutical, food and non-food applications of modified starches: a critical review." EJEAFChe 9.7 (2010): 1214-1221.â€

      [16] Greenhalgh, Kerriann, and Edward Turos. "In vivo studies of polyacrylate nanoparticle emulsions for topical and systemic applications." Nanomedicine: Nanotechnology, biology and medicine 5.1 (2009): 46-54.â€

      [17] Paradossi, Gaio, et al. "Poly (vinyl alcohol) as versatile biomaterial for potential biomedical applications." Journal of Materials Science: Materials in Medicine 14.8 (2003): 687-691.â€

      [18] Mora-Huertas, C. E., HatemFessi, and AbdelhamidElaissari. "Polymer-based nanocapsules for drug delivery." International journal of pharmaceutics 385.1-2 (2010): 113-142.â€

      [19] Makadia, Hirenkumar K., and Steven J. Siegel. "Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier." Polymers 3.3 (2011): 1377-1397.â€

      [20] Mulchandani, Neha, Nimish Shah, and Tejal Mehta. "Synthesis of Chitosan-Polyvinyl Alcohol Copolymers for Smart Drug Delivery Application." Polymers & Polymer Composites 25.3 (2017): 241.â€

      [21] Qiu, Shuang, et al. Synthesis and Characterization of Magnetic Polyvinyl Alcohol ( PVA ) Hydrogel Microspheres for the Embolization of Blood Vessel. no. November 2016, 2015, doi:10.1109/TBME.2015.2469735

      [22] Malafaya, Patrícia B., Frank Stappers, and Rui L. Reis. "Starch-based microspheres produced by emulsion crosslinking with a potential media dependent responsive behavior to be used as drug delivery carriers." Journal of materials science: Materials in medicine 17.4 (2006): 371-377.â€

      [23] Mishra, Munmaya K. "Overview of encapsulation and controlled release." Handbook of Encapsulation and Controlled Release(2016): 3-19.â€

  • Downloads

  • How to Cite

    Jawad Hadi, N., Jabbar Braihi, A., & Kareem Mohammed, S. (2018). Effect of Flow Behavior on the Production of PVA/Dextrin Microspheres. International Journal of Engineering & Technology, 7(4.19), 669-675. https://doi.org/10.14419/ijet.v7i4.19.27979

    Received date: 2019-02-26

    Accepted date: 2019-02-26

    Published date: 2018-11-27