Calcium Phosphate Bone Cement Prepared Using Wet Precipitation Method at Powder-to-Liquid Ratios of 1.3 and 1.7

  • Authors

    • Sufiamie Hablee
    • Iis Sopyan
    • Maizirwan Mel
    • Hamzah Mohd. Salleh
    • Md. Mujibur Rahman
    • Ramesh Singh
    https://doi.org/10.14419/ijet.v7i4.38.29231
  • Calcium phosphate cement, Hydroxyapatite, Injectable, Poly(ethylene glycol), Wet chemical precipitation method

  • Calcium phosphate/poly(ethylene glycol) composite for bone cement use has been developed by incorporating poly(ethylene glycol) (PEG) into calcium phosphate cement (CPC) prepared using wet chemical precipitation method with the powder-to-liquid (P/L) ratios of 1.3 and 1.7. The precursors used in the synthesis are calcium hydroxide, Ca(OH)2, and diammonium hydrogen phosphate, (NH4)2HPO4. The effect of PEG addition on injectability, setting behaviour, mechanical properties and anti-washout performance of CPC was investigated. The results indicated that PEG addition significantly improved setting time, injectability, compressive strength as well as anti-washout performance of CPC. The initial and final setting times of PEG free CPC with the P/L ratio of 1.3 are 88 min and 228 min, respectively. The addition of 4% PEG shortened both the initial and final settimg times to 47 min and 182 min, respectively. Without PEG, CPC with the P/L ratio of 1.7 has the compressive strength of 0.25 MPa. The compressive strength increased to 1.553 MPa when 5% PEG was added. The anti-washout properties of CPC/PEG is excellent with no cement dissolution throughout 28 days soaking period.

     

     

  • References

    1. [1] Barinov, S.M., et al., Calcium phosphate bone cements. Inorganic Materials, 2011. 47(13): p. 1470-1485.

      [2] Dorozhkin, S.V., Self-setting orthophosphate formulations: cements, concretes, pastes and putties. International Journal of Materials and Chemistry, 2011. 1(1): p. 1-48.

      [3] Sugawara, A., et al., Calcium phosphate-based cements: clinical needs and recent progress. Journal of Materials Chemistry B, 2013. 1: p. 1081-1089.

      [4] Perez, R.A., et al., Polymeric additives to enhance the functional properties of calcium phosphate cements. Journal of Tissue Engineering, 2012. 3(1): p. 1-20.

      [5] Engstrand, J., et al., Influence of polymer addition on the mechanical properties of a premixed calcium phosphate cement. Biomatter, 2013. 3(4): e27249.

      [6] Chen, F., et al., Preparation and characterization of injectable calcium phosphate cement paste modified by polyethylene glycol-6000. Materials Chemistry and Physics, 2011. 125: p. 81800-81824.

      [7] Hablee, S., et al., Novel injectable calcium phosphate bone cement from wet chemical precipitation method. IOP Conf. Series: Materials Science and Engineering, 2017. 205: 012012.

      [8] Wang, X., et al., Effects of additives on the rheological properties and injectability of calcium phosphate bone substitute material. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2006. 78(2): p. 259-264.

      [9] Hesaraki, S., et al., Rheological properties and injectability of β–tricalcium phosphate-hyaluronic acid/polyethylene glycol composites used for the treatment of vesicouretheral reflux. Advances in Biomedical Engineering Research (ABER), 2013. 1(3): p. 40-44.

      [10] Yousefi, K., et al., Comparison of polyethylene glycol effect on hydroxyapatite morphology produced into different methods: sol-gel and precipitation. J. Sol-Gel Sci. Technol., 2015. 76: p. 592-598.

      [11] Mohammadi, M., et al., Comparative study of in-vitro behavior of tetracalcium phosphate-based cement: ringer’s solution versus human blood plasma. International Journal of Engineering Practical Research (IJEPR), 2014. 3(1): p. 1-7.

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  • How to Cite

    Hablee, S., Sopyan, I., Mel, M., Mohd. Salleh, H., Mujibur Rahman, M., & Singh, R. (2018). Calcium Phosphate Bone Cement Prepared Using Wet Precipitation Method at Powder-to-Liquid Ratios of 1.3 and 1.7. International Journal of Engineering & Technology, 7(4.38), 1673-1676. https://doi.org/10.14419/ijet.v7i4.38.29231